{"created":"2024-10-29T01:07:57.395401+00:00","id":2006901,"links":{},"metadata":{"_buckets":{"deposit":"2f73d49b-b0c5-4350-bf8d-60aea177011b"},"_deposit":{"created_by":7,"id":"2006901","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2006901"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02006901","sets":["1713853213384:1713853295607"]},"author_link":["716","760"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-19","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"B","bibliographicPageEnd":"1615","bibliographicPageStart":"1610","bibliographicVolumeNumber":"245","bibliographic_titles":[{"bibliographic_title":"Bioresource Technology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The aim of this work was to study the molecular breeding of oleaginous filamentous Mortierella alpina for high production of linoleic (LA) or oleic acid (OA).  Heterologous expression of the Δ12-desaturase (DS) gene derived from Coprinopsis cinerea in the Δ6DS activity-defective mutant of M. alpina increased the LA production rate as to total fatty acid to 5 times that in the wild strain.  By suppressing the endogenous Δ6I gene expression by RNAi in the Δ12DS activity-defective mutant of M. alpina, the OA accumulation rate as to total fatty acid reached 68.0%.  The production of LA and OA in these transformants reached 1.44 and 2.76 g/L, respectively, on the 5th day.  The Δ6I transcriptional levels of the RNAi-treated strains were suppressed to 1/10th that in the parent strain.  The amount of Δ6II RNA in the Δ6I RNAi-treated strain increased to 8 times that in the wild strain.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"18732976","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"09608524","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11522750","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA10838373","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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Jun","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オガワ, ジュン","creatorNameLang":"ja"},{"creatorName":"オガワ, ジュン","creatorNameLang":"ja-Kana"},{"creatorName":"Ogawa, Jun","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-11-08"}],"displaytype":"detail","filename":"biortech_245_B_1610.pdf","filesize":[{"value":"945 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2006901/files/biortech_245_B_1610.pdf"},"version_id":"7c1a30f1-1dab-4697-a392-ef714cd6db58"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Mortierella alpina","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Oleic acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Linoleic acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fatty acid desaturase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"RNAi","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Metabolic engineering of oleaginous fungus Mortierella alpina for high production of oleic and linoleic acids","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Metabolic engineering of oleaginous fungus Mortierella alpina for high production of oleic and linoleic 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