{"created":"2024-10-29T01:10:24.157807+00:00","id":2006934,"links":{},"metadata":{"_buckets":{"deposit":"04a16c73-5475-4dfd-a1e5-2271b9c409c6"},"_deposit":{"created_by":7,"id":"2006934","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2006934"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02006934","sets":["1713853213384:1713853295607"]},"author_link":["481","1147","1215"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-10-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"263","bibliographicPageStart":"257","bibliographicVolumeNumber":"35","bibliographic_titles":[{"bibliographic_title":"Journal of Assisted Reproduction and Genetics","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose\nRecently, a genome-wide association studies of a Hutterite population in the USA revealed that five single nucleotide polymorphisms (SNPs) with a significant association with sperm quality and/or function in ethnically diverse men from Chicago were significantly correlated with family size. Of these, three SNPs (rs7867029, rs7174015, and rs12870438) were found to be significantly associated with the risk of azoospermia and/or oligozoospermia in a Japanese population. In this study, we investigated whether the rs10966811 (located in an intergenic region between the TUSC1 and IZUMO3 genes) and rs10129954 (located in the DPF3 gene) SNPs, previously related to family size, are associated with male infertility. In addition, we performed association analysis between rs12348 in TUSC1 and rs2772579 in IZUMO3 and male infertility.\nMethods\nWe genotyped 145 patients with infertility (including 83 patients with azoospermia, and 62 with oligozoospermia) and 713 fertile controls by PCR-RFLP technique for polymorphism. Because rs10966811 has no restriction sites, the SNP rs12376894 with strong linkage disequilibrium was selected as an alternative to rs10966811.\nResults\nThere was a statistically significant association between rs12376894 proxy SNP of rs10966811, and oligozoospermia. A statistically significant association between rs10129954 and azoospermia, and oligozoospermia were observed. When we assessed the relationship between rs12348 in TUSC1 and rs2772579 in IZUMO3 and male infertility traits, we found that rs12348 in TUSC1 was significantly associated with azoospermia and oligozoospermia, but rs2772579 in IZUMO3 was not associated with male infertility.\nConclusion\nWe found that the polymorphisms in TUSC1 and DPF3 displayed strong associations with male infertility.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer US","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"10580468","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"15737330","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10830983","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"This is a post-peer-review, pre-copyedit version of an article published in Journal of Assisted Reproduction and Genetics. The final authenticated version is available online at: https://doi.org/10.1007/s10815-017-1052-x."}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1007/s10815-017-1052-x"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s10815-017-1052-x","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"336836"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"佐藤, 陽一","creatorNameLang":"ja"},{"creatorName":"サトウ, ヨウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Sato, Youichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"佐藤","familyNameLang":"ja"},{"familyName":"サトウ","familyNameLang":"ja-Kana"},{"familyName":"Sato","familyNameLang":"en"}],"givenNames":[{"givenName":"陽一","givenNameLang":"ja"},{"givenName":"ヨウイチ","givenNameLang":"ja-Kana"},{"givenName":"Youichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1215","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"73845/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/73845/profile-ja.html"},{"nameIdentifier":"10363160","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10363160"}]},{"creatorNames":[{"creatorName":"ハセガワ, チセ","creatorNameLang":"ja"},{"creatorName":"ハセガワ, チセ","creatorNameLang":"ja-Kana"},{"creatorName":"Hasegawa, 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エイテツ","creatorNameLang":"ja-Kana"},{"creatorName":"Koh, Eitetsue","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カナヤ, ジロウ","creatorNameLang":"ja"},{"creatorName":"カナヤ, ジロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Kanaya, Jiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ナミキ, ミキオ","creatorNameLang":"ja"},{"creatorName":"ナミキ, ミキオ","creatorNameLang":"ja-Kana"},{"creatorName":"Namiki, Mikio","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マツミヤ, キヨミ","creatorNameLang":"ja"},{"creatorName":"マツミヤ, キヨミ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsumiya, Kiyomi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ツジムラ, アキラ","creatorNameLang":"ja"},{"creatorName":"ツジムラ, アキラ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsujimura, Akira","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"コマツ, キヨシ","creatorNameLang":"ja"},{"creatorName":"コマツ, キヨシ","creatorNameLang":"ja-Kana"},{"creatorName":"Komatsu, Kiyoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イトウ, ナオキ","creatorNameLang":"ja"},{"creatorName":"イトウ, ナオキ","creatorNameLang":"ja-Kana"},{"creatorName":"Itoh, Naoki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"エグチ, ジロウ","creatorNameLang":"ja"},{"creatorName":"エグチ, ジロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Eguchi, Jiro","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"山内, あい子","creatorNameLang":"ja"},{"creatorName":"ヤマウチ, アイコ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamauchi, Aiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"山内","familyNameLang":"ja"},{"familyName":"ヤマウチ","familyNameLang":"ja-Kana"},{"familyName":"Yamauchi","familyNameLang":"en"}],"givenNames":[{"givenName":"あい子","givenNameLang":"ja"},{"givenName":"アイコ","givenNameLang":"ja-Kana"},{"givenName":"Aiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1147","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60647/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60647/profile-ja.html"},{"nameIdentifier":"30122253","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=30122253"}]},{"creatorNames":[{"creatorName":"イワモト, テルアキ","creatorNameLang":"ja"},{"creatorName":"イワモト, テルアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Iwamoto, Teruaki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-11-26"}],"displaytype":"detail","filename":"jarg_35_2_257.pdf","filesize":[{"value":"916 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2006934/files/jarg_35_2_257.pdf"},"version_id":"14483b8c-bf4b-4043-97a8-c918f467f43a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Single nucleotide polymorphism","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Male infertility","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Azoospermia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Oligozoospermia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tumor suppressor candidate 1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Double plant homeodomain fingers","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Family 3","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Association of TUSC1 and DPF3 gene polymorphisms with male infertility","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association of TUSC1 and DPF3 gene polymorphisms with male infertility","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-11-26"},"publish_date":"2019-11-26","publish_status":"0","recid":"2006934","relation_version_is_last":true,"title":["Association of TUSC1 and DPF3 gene polymorphisms with male infertility"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-14T00:13:22.489503+00:00"}