{"created":"2024-10-29T01:11:14.753843+00:00","id":2006944,"links":{},"metadata":{"_buckets":{"deposit":"92aec611-31ea-40a1-8c00-3b448c8858cf"},"_deposit":{"created_by":7,"id":"2006944","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2006944"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02006944","sets":["1713853213384:1713853295607"]},"author_link":["195"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Potassium Channels in Pulmonary Arterial Hypertension","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"198","bibliographicPageStart":"189","bibliographicVolumeNumber":"32","bibliographic_titles":[{"bibliographic_title":"日本小児循環器学会雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Pediatric Cardiology and Cardiac Surgery","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Potassium channels play diverse roles in regulating the behavior of pulmonary artery smooth muscle cells. In 2013, the discovery of KCNK3 (TASK1) as a new predisposing gene for pulmonary arterial hypertension (PAH) led to an update in the Nice Classification regarding the genetic origin of PAH. Decreased current via KCNA5 (Kv1.5) plays a key role in determining pulmonary arterial tone and vascular remodeling. The transformation of smooth muscle cells causes ion channel switching, such as the loss of BKca (Kca1.1) and the gain of IKca (Kca3.1), in immature proliferative smooth muscle cells and also induces cell migration, proliferation, and apoptosis resistance. Pulmonary smooth muscle cells from PAH patients demonstrate many cellular abnormalities linked to potassium channels. This review summarizes the current knowledge regarding the involvement of potassium channels in the development of PAH and discusses potential treatments to be developed in the near feature.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"肺動脈平滑筋細胞に存在するカリウムチャネルは多彩な種類と機能を有し，多くの生理作用ならびに病態に関与している．肺動脈性肺高血圧症(PAH)においても発症と増悪に深く関与していることが明らかになりつつある．2013年にtwo-pore domainカリウムチャネルの1種であるKCNK3(TASK1)の遺伝子変異がPAHの原因遺伝子であると証明され，第5回肺高血圧国際シンポジウム(ニース国際会議)で追加された．また，PAHでは発症原因にかかわらず，電位依存性カリウムチャネル，特にKCNA5(Kv1.5)の発現低下と活性抑制が認められ，肺動脈収縮と血管リモデリングを促進することが示されている．さらに，平滑筋細胞に認められるカルシウム活性化カリウムチャネルは，形質転換によってBKca(Kca1.1)からIKca(Kca3.1)優位に変化し，平滑筋細胞の遊走の促進，増殖能の亢進，アポトーシスの抑制などに影響を与えている．これら肺血管の収縮とリモデリングへのカリウムチャネルの役割を解明することで，新たな治療戦略が見えてくるものと期待される．","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本小児循環器学会","subitem_publisher_language":"ja"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2016 Japanese Society of Pediatric Cardiology and Cardiac Surgery","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"09111794","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"21872988","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AN10042853","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.9794/jspccs.32.189"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.9794/jspccs.32.189","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"313320"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"早渕, 康信","creatorNameLang":"ja"},{"creatorName":"ハヤブチ, ヤスノブ","creatorNameLang":"ja-Kana"},{"creatorName":"Hayabuchi, Yasunobu","creatorNameLang":"en"}],"familyNames":[{"familyName":"早渕","familyNameLang":"ja"},{"familyName":"ハヤブチ","familyNameLang":"ja-Kana"},{"familyName":"Hayabuchi","familyNameLang":"en"}],"givenNames":[{"givenName":"康信","givenNameLang":"ja"},{"givenName":"ヤスノブ","givenNameLang":"ja-Kana"},{"givenName":"Yasunobu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"195","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"122001/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/122001/profile-ja.html"},{"nameIdentifier":"20403686","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=20403686"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-12-05"}],"displaytype":"detail","filename":"jspccs_32_3_189.pdf","filesize":[{"value":"2.2 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