{"created":"2024-10-29T01:11:27.179045+00:00","id":2006947,"links":{},"metadata":{"_buckets":{"deposit":"747bf128-09a8-41a9-8bf2-592a70bdacf2"},"_deposit":{"created_by":7,"id":"2006947","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2006947"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02006947","sets":["1713853213384:1713853295607"]},"author_link":["195"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-11-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"14","bibliographicPageStart":"1","bibliographicVolumeNumber":"38","bibliographic_titles":[{"bibliographic_title":"Pediatric Cardiology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Many different types of potassium channels with various functions exist in pulmonary artery smooth muscle cells, contributing to many physiological actions and pathological conditions. The deep involvement of these channels in the onset and exacerbation of pulmonary arterial hypertension (PAH) also continues to be revealed. In 2013, KCNK3 (TASK1), which encodes a type of two-pore domain potassium channel, was shown to be a predisposing gene for PAH by genetic mutation, and it was added to the PAH classification at the Fifth World Symposium on Pulmonary Hypertension (Nice International Conference). Decreased expression and inhibited activity of voltage-gated potassium channels, particularly KCNA5 (Kv1.5), are also seen in PAH, regardless of the cause, and facilitation of pulmonary arterial contraction and vascular remodeling has been shown. The calcium-activated potassium channels seen in smooth muscle cells also change from BKca (Kca1.1) to IKca (Kca3.1) predominance in PAH due to transformation, and have effects including the facilitation of smooth muscle cell migration, enhancement of proliferation, and inhibition of apoptosis. Elucidation of these roles for potassium channels in pulmonary vasoconstriction and remodeling may help bring new therapeutic strategies into view.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer US","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"01720643","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"14321971","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00361536","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"This is a post-peer-review, pre-copyedit version of an article published in Pediatric Cardiology. The final authenticated version is available online at: https://doi.org/10.1007/s00246-016-1491-7."}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1007/s00246-016-1491-7"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s00246-016-1491-7","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"324460"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"早渕, 康信","creatorNameLang":"ja"},{"creatorName":"ハヤブチ, ヤスノブ","creatorNameLang":"ja-Kana"},{"creatorName":"Hayabuchi, Yasunobu","creatorNameLang":"en"}],"familyNames":[{"familyName":"早渕","familyNameLang":"ja"},{"familyName":"ハヤブチ","familyNameLang":"ja-Kana"},{"familyName":"Hayabuchi","familyNameLang":"en"}],"givenNames":[{"givenName":"康信","givenNameLang":"ja"},{"givenName":"ヤスノブ","givenNameLang":"ja-Kana"},{"givenName":"Yasunobu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"195","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"122001/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/122001/profile-ja.html"},{"nameIdentifier":"20403686","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=20403686"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-12-06"}],"displaytype":"detail","filename":"pc_38_1_1.pdf","filesize":[{"value":"2.06 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2006947/files/pc_38_1_1.pdf"},"version_id":"0c61b68e-7e3e-4c5b-badb-e9f0b51604c8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Pulmonary arterial hypertension","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Potassium channel","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Smooth muscle cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Vascular remodeling","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The Action of Smooth Muscle Cell Potassium Channels in the Pathology of Pulmonary Arterial Hypertension","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The Action of Smooth Muscle Cell Potassium Channels in the Pathology of Pulmonary Arterial Hypertension","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-12-06"},"publish_date":"2019-12-06","publish_status":"0","recid":"2006947","relation_version_is_last":true,"title":["The Action of Smooth Muscle Cell Potassium Channels in the Pathology of Pulmonary Arterial Hypertension"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T04:16:25.301647+00:00"}