{"created":"2024-10-29T01:13:41.506121+00:00","id":2006974,"links":{},"metadata":{"_buckets":{"deposit":"ac3d428f-dde4-4c6c-9a53-2928294f58dd"},"_deposit":{"created_by":7,"id":"2006974","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2006974"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02006974","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["639","270","1265","1554","884","1558","1537","1536"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"免疫組織化学法を用いた一側内耳破壊ラットの前庭代償の新しい評価法の開発","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-04-16","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"510","bibliographicPageStart":"505","bibliographicVolumeNumber":"139","bibliographic_titles":[{"bibliographic_title":" Acta Oto-Laryngologica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Unilateral labyrinthectomy (UL) causes the disappearance of ipsilateral medial vestibular nuclear (ipsi-MVe) activity and induces spontaneous nystagmus (SN), which disappears during the initial process of vestibular compensation (VC). Ipsi-MVe-activity restores in the late process of VC.\nObjective: We evaluated the late process of VC after UL in rats and examined the effects of thioperamide (H3 antagonist) on VC.\nMaterials and methods: MK801 (NMDA antagonist)-induced Fos-like immunoreactive (-LIR) neurons in contra-MVe, which had been suppressed by NMDA-mediated cerebellar inhibition in UL-rats was used as an index.\nResults: The number of MK801-induced Fos-LIR neurons in contra-MVe gradually decreased to the same level as that of sham-operated rats 14 days after UL. Thioperamide moved the disappearance of the MK801-induced Fos-LIR neurons 2 days earlier. The number of MK801-induced Fos-LIR neurons in thioperamide-treated rats was significantly decreased, compared with that of vehicle-rats on days 7 and 12 after UL. But, thioperamide did not influence the decline of SN frequency in UL-rats.\nConclusion: There findings suggested that the number of MK801-induced Fos-LIR neurons in contra-MVe was decreased in concordance with the restoration of ipsi-MVe-activity during the late process of VC after UL and that thioperamide accelerated the late, but not the initial process of VC.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Taylor & Francis","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"00016489","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"16512251","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA0050923X","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3339号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2019-10-24"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Kazunori Matsudaの学位論文として提出され，学位審査・授与の対象となっている。\nThis is an Accepted Manuscript of an article published by Taylor & Francis in Acta Oto-Laryngologica on 16/04/2019, available online: http://www.tandfonline.com/10.1080/00016489.2019.1599140\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1432号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1080/00016489.2019.1599140"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1080/00016489.2019.1599140","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"365493"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松田, 和徳","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"639","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"キタハラ, タダシ","creatorNameLang":"ja"},{"creatorName":"キタハラ, タダシ","creatorNameLang":"ja-Kana"},{"creatorName":"Kitahara, Tadashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イトウ, タエコ","creatorNameLang":"ja"},{"creatorName":"イトウ, タエコ","creatorNameLang":"ja-Kana"},{"creatorName":"Ito, Taeko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"フクシマ, ムネヒサ","creatorNameLang":"ja"},{"creatorName":"フクシマ, ムネヒサ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukushima, Munehisa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"福田, 潤弥","creatorNameLang":"ja"},{"creatorName":"フクダ, ジュンヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukuda, Junya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"佐藤, 豪","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"270","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"北村, 嘉章","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1265","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"阿部, 晃治","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1554","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ウノ, アツヒコ","creatorNameLang":"ja"},{"creatorName":"ウノ, アツヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Uno, Atsuhiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"冨田, 江一","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"884","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"坂田, ひろみ","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1558","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福井, 義浩","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1537","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武田, 憲昭","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1536","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-11-14"}],"displaytype":"detail","filename":"k3339_abstract_review.pdf","filesize":[{"value":"192 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2006974/files/k3339_abstract_review.pdf"},"version_id":"089decdf-2da9-4c8f-b3f0-2f132da61e83"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-04-28"}],"displaytype":"detail","filename":"k3339_fulltext.pdf","filesize":[{"value":"598 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2006974/files/k3339_fulltext.pdf"},"version_id":"9d526c9c-ca76-4b9f-976b-2463da53843c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Vestibular compensation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"medial vestibular nucleus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"spontaneous nystagmus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fos","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"thioperamide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"N-methyl-D-aspartate receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"A new immunohistochemical method to evaluate the development of vestibular compensation after unilateral labyrinthectomy in rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A new immunohistochemical method to evaluate the development of vestibular compensation after unilateral labyrinthectomy in rats","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-11-14"},"publish_date":"2019-11-14","publish_status":"0","recid":"2006974","relation_version_is_last":true,"title":["A new immunohistochemical method to evaluate the development of vestibular compensation after unilateral labyrinthectomy in rats"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-29T01:13:53.373610+00:00"}