{"created":"2024-10-29T01:19:46.503525+00:00","id":2007049,"links":{},"metadata":{"_buckets":{"deposit":"9b47fef8-f273-4ca6-9ac6-b94b4c2a4cb7"},"_deposit":{"created_by":7,"id":"2007049","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007049"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007049","sets":["1713853213384:1713853295607"]},"author_link":["306","1533"],"control_number":"2007049","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-02-24","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"639","bibliographicPageStart":"631","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"International Journal of Neuropsychopharmacology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: An imbalance in the inflammatory tumor necrosis factor system, including soluble tumor necrosis factor receptor 2 (sTNFR2), may contribute to the pathophysiology of schizophrenia.\nMethods: We measured the plasma levels of sTNFR2 in 256 healthy controls and 250 patients with schizophrenia including antipsychotic drug-free patients and treatment-resistant patients. We also explored the possible association between plasma sTNFR2 levels and cognitive performance in healthy controls and patients with schizophrenia using the Wechsler Adult Intelligence Scale, Third Edition, the Wechsler Memory Scale-Revised, and the Rey Auditory Verbal Learning Test. An association between plasma sTNFR2 levels and hippocampal volume in controls and patients with schizophrenia was also investigated via MRI.\nResults: We found that the plasma levels of sTNFR2 were significantly higher in patients with schizophrenia, including both antipsychotic drug-free patients and treatment-resistant patients. We found a significant negative association between plasma sTNFR2 levels and cognitive performance in controls and patients with schizophrenia. Hippocampal volume was also negatively associated with plasma sTNFR2 levels in patients with schizophrenia.\nConclusion: Together, these convergent data suggest a possible biological mechanism for schizophrenia, whereby increased sTNFR2 levels are associated with a smaller hippocampal volume and cognitive impairment.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Oxford University Press","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14611457","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"14695111","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11545519","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1093/ijnp/pyy013"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1093/ijnp/pyy013","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"339432"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"クドウ, ノリコ","creatorNameLang":"ja"},{"creatorName":"クドウ, ノリコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kudo, Noriko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤマモリ, ヒデナガ","creatorNameLang":"ja"},{"creatorName":"ヤマモリ, ヒデナガ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamamori, Hidenaga","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イシマ, タマキ","creatorNameLang":"ja"},{"creatorName":"イシマ, タマキ","creatorNameLang":"ja-Kana"},{"creatorName":"Ishima, Tamaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ネモト, キヨタカ","creatorNameLang":"ja"},{"creatorName":"ネモト, キヨタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Nemoto, Kiyotaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤスダ, ユカ","creatorNameLang":"ja"},{"creatorName":"ヤスダ, ユカ","creatorNameLang":"ja-Kana"},{"creatorName":"Yasuda, Yuka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"フジモト, ミチコ","creatorNameLang":"ja"},{"creatorName":"フジモト, ミチコ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujimoto, Michiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"アゼチ, ヒロツグ","creatorNameLang":"ja"},{"creatorName":"アゼチ, ヒロツグ","creatorNameLang":"ja-Kana"},{"creatorName":"Azechi, Hirotsugu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ニイツ, トミヒサ","creatorNameLang":"ja"},{"creatorName":"ニイツ, トミヒサ","creatorNameLang":"ja-Kana"},{"creatorName":"Niitsu, Tomihisa","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"沼田, 周助","creatorNameLang":"ja"},{"creatorName":"ヌマタ, シュウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Numata, Shusuke","creatorNameLang":"en"}],"familyNames":[{"familyName":"沼田","familyNameLang":"ja"},{"familyName":"ヌマタ","familyNameLang":"ja-Kana"},{"familyName":"Numata","familyNameLang":"en"}],"givenNames":[{"givenName":"周助","givenNameLang":"ja"},{"givenName":"シュウスケ","givenNameLang":"ja-Kana"},{"givenName":"Shusuke","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"306","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"172447/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/172447/profile-ja.html"},{"nameIdentifier":"10403726","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10403726"}]},{"creatorNames":[{"creatorName":"イケダ, マナブ","creatorNameLang":"ja"},{"creatorName":"イケダ, マナブ","creatorNameLang":"ja-Kana"},{"creatorName":"Ikeda, Manabu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イヨ, マサオミ","creatorNameLang":"ja"},{"creatorName":"イヨ, マサオミ","creatorNameLang":"ja-Kana"},{"creatorName":"Iyo, Masaomi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"大森, 哲郎","creatorNameLang":"ja"},{"creatorName":"オオモリ, テツロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohmori, Tetsuro","creatorNameLang":"en"}],"familyNames":[{"familyName":"大森","familyNameLang":"ja"},{"familyName":"オオモリ","familyNameLang":"ja-Kana"},{"familyName":"Ohmori","familyNameLang":"en"}],"givenNames":[{"givenName":"哲郎","givenNameLang":"ja"},{"givenName":"テツロウ","givenNameLang":"ja-Kana"},{"givenName":"Tetsuro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1533","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60046/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60046/profile-ja.html"},{"nameIdentifier":"00221135","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=00221135"}]},{"creatorNames":[{"creatorName":"フクナガ, マサキ","creatorNameLang":"ja"},{"creatorName":"フクナガ, マサキ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukunaga, Masaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ワタナベ, ヨシユキ","creatorNameLang":"ja"},{"creatorName":"ワタナベ, ヨシユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Watanabe, Yoshiyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハシモト, ケンジ","creatorNameLang":"ja"},{"creatorName":"ハシモト, ケンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Hashimoto, Kenji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハシモト, リョウタ","creatorNameLang":"ja"},{"creatorName":"ハシモト, リョウタ","creatorNameLang":"ja-Kana"},{"creatorName":"Hashimoto, Ryota","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-12-12"}],"displaytype":"detail","filename":"ijnp_21_7_631.pdf","filesize":[{"value":"2.16 MB"}],"format":"application/pdf","licensetype":"license_3","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007049/files/ijnp_21_7_631.pdf"},"version_id":"e2da10eb-69ff-4ecd-ace8-cce1f08c0efc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"soluble tumor necrosis factor receptor 2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cognitive performance","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hippocampal volume","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Plasma Levels of Soluble Tumor Necrosis Factor Receptor 2 (sTNFR2) Are Associated with Hippocampal Volume and Cognitive Performance in Patients with Schizophrenia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Plasma Levels of Soluble Tumor Necrosis Factor Receptor 2 (sTNFR2) Are Associated with Hippocampal Volume and Cognitive Performance in Patients with Schizophrenia","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-12-12"},"publish_date":"2019-12-12","publish_status":"0","recid":"2007049","relation_version_is_last":true,"title":["Plasma Levels of Soluble Tumor Necrosis Factor Receptor 2 (sTNFR2) Are Associated with Hippocampal Volume and Cognitive Performance in Patients with Schizophrenia"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-12T00:18:41.837723+00:00"}