{"created":"2024-10-29T01:20:18.694710+00:00","id":2007055,"links":{},"metadata":{"_buckets":{"deposit":"8e46ee25-a7d3-4b36-bb7f-ef93c7509ade"},"_deposit":{"created_by":7,"id":"2007055","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007055"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007055","sets":["1713853213384:1713853295607"]},"author_link":["1131","1139"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-11-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"951","bibliographicPageStart":"947","bibliographicVolumeNumber":"521","bibliographic_titles":[{"bibliographic_title":"Biochemical and Biophysical Research Communications","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"α-Tocopheryl succinate (TS) is a tocopherol derivative and has multifaceted anti-cancer effects; TS not only causes cancer cell-specific apoptosis but also inhibits tumor angiogenesis. Although TS has the potential to be used as a well-tolerated anti-angiogenic drug, it is still unclear which step of the angiogenic process is inhibited by TS. Here, we show that TS inhibits the expression of angiopoietin (Ang)-2, which induces destabilization of vascular structure in the initial steps of the angiogenic process. In mouse melanoma cells, TS treatment decreased mRNA and extracellular protein levels of Ang-2; however, the mRNA level of Ang-1, which stabilizes the vascular structure, remained unchanged. Furthermore, aorta ring and Matrigel plug angiogenesis assays indicated that the conditioned medium from TS-treated cells (CM-TS) inhibited neovascularization and blood leakage from the existing blood vessels, respectively. Following immunohistochemical staining of the vessels treated with CM-TS, imaging studies showed that the vascular endothelial cells were highly packed with pericytes. In conclusion, we found that TS inhibits Ang-2 expression and, consequently, stabilizes the vascular structure during the initial step of tumor angiogenesis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"0006291X","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00564395","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA11542044","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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カズホ","creatorNameLang":"ja"},{"creatorName":"カメイ, カズホ","creatorNameLang":"ja-Kana"},{"creatorName":"Kamei, Kazuho","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ナガオ, サキ","creatorNameLang":"ja"},{"creatorName":"ナガオ, サキ","creatorNameLang":"ja-Kana"},{"creatorName":"Nagao, Saki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハヤシ, マリ","creatorNameLang":"ja"},{"creatorName":"ハヤシ, マリ","creatorNameLang":"ja-Kana"},{"creatorName":"Hayashi, Mari","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マエダ, シズカ","creatorNameLang":"ja"},{"creatorName":"マエダ, シズカ","creatorNameLang":"ja-Kana"},{"creatorName":"Maeda, Shizuka","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"福澤, 健治","creatorNameLang":"ja"},{"creatorName":"フクザワ, ケンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukuzawa, Kenji","creatorNameLang":"en"}],"familyNames":[{"familyName":"福澤","familyNameLang":"ja"},{"familyName":"フクザワ","familyNameLang":"ja-Kana"},{"familyName":"Fukuzawa","familyNameLang":"en"}],"givenNames":[{"givenName":"健治","givenNameLang":"ja"},{"givenName":"ケンジ","givenNameLang":"ja-Kana"},{"givenName":"Kenji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1131","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60628/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60628/profile-ja.html"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"小暮, 健太朗","creatorNameLang":"ja"},{"creatorName":"コグレ, ケンタロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Kogure, Kentaro","creatorNameLang":"en"}],"familyNames":[{"familyName":"小暮","familyNameLang":"ja"},{"familyName":"コグレ","familyNameLang":"ja-Kana"},{"familyName":"Kogure","familyNameLang":"en"}],"givenNames":[{"givenName":"健太朗","givenNameLang":"ja"},{"givenName":"ケンタロウ","givenNameLang":"ja-Kana"},{"givenName":"Kentaro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1139","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60638/profile-ja.html","nameIdentifierScheme":"徳島大学 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succinate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Angiogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Angiopoietin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Vascular stabilization","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"α-Tocopheryl succinate stabilizes the structure of tumor vessels by inhibiting angiopoietin-2 expression","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"α-Tocopheryl succinate stabilizes the structure of tumor vessels by inhibiting angiopoietin-2 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