{"created":"2024-10-29T01:22:51.849687+00:00","id":2007087,"links":{},"metadata":{"_buckets":{"deposit":"556ef032-5d62-41c7-847c-b7b7e97cbd9a"},"_deposit":{"created_by":7,"id":"2007087","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007087"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007087","sets":["1713853213384:1713853295607"]},"author_link":["306","1533","893"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Vitamin B6 and schizophrenia","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-10-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"456","bibliographicPageStart":"450","bibliographicVolumeNumber":"92","bibliographic_titles":[{"bibliographic_title":"ビタミン","bibliographic_titleLang":"ja"},{"bibliographic_title":"Vitamins","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Accumulating evidence indicates that alterations in one-carbon metabolism may play an important role in the pathogenesis of schizophrenia. We focused on vitamin B6 (pyridoxal), which works as a coenzyme in one-carbon metabolism. We first conducted a case-control study and demonstrated that serum pyridoxal levels were significantly lower in the schizophrenia group than in the control group. Subsequently, we conducted a meta-analysis of case-control studies and achieved the similar result to the case-control study. Finally, we investigated the causality between serum pyridoxal levels and schizophrenia by a Mendelian randomization analysis. However, we could indicate no significant causality between serum pyridoxal levels and schizophrenia in the Japanese population. Further studies such as a longitudinal study will be needed because there are several studies on the benefits of vitamin B6 in schizophrenia.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本ビタミン学会","subitem_publisher_language":"ja"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"0006386X","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"2424080X","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11693298","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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metabolism","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Homocysteine","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ビタミンB6と統合失調症","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ビタミンB6と統合失調症","subitem_title_language":"ja"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-01-10"},"publish_date":"2020-01-10","publish_status":"0","recid":"2007087","relation_version_is_last":true,"title":["ビタミンB6と統合失調症"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-12T00:18:37.627142+00:00"}