{"created":"2024-10-29T01:26:07.496458+00:00","id":2007125,"links":{},"metadata":{"_buckets":{"deposit":"20741581-8dd0-4f62-9736-62ee539e6b90"},"_deposit":{"created_by":7,"id":"2007125","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007125"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007125","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["265","1253","931","702","193","1266","603"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Epigallocatechin 3-gallateのNrf2経路を介したマウス膵島細胞保護作用に関する検討","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"protective effect of EGCG on mouse islets","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-02-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"545","bibliographicPageStart":"536","bibliographicVolumeNumber":"49","bibliographic_titles":[{"bibliographic_title":"Surgery Today","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: Epigallocatechin 3-gallate (EGCG), a green tea polyphenol, has been shown to have anti-oxidant and anti-inflammatory effects in vitro and in vivo. The aim of this study was to investigate the effects and mechanism of EGCG on isolated pancreatic islets as pre-conditioning for pancreatic islet transplantation.\nMethods: The pancreatic islets were divided into two groups: an islet culture medium group (control) and an islet culture medium with EGCG (100 μM) group. We investigated the islet viability, Nrf2 expression, reactive oxygen species (ROS) production, and heme oxygenase-1 (HO-1) mRNA. Five hundred islet equivalents after 12 h of culture for the EGCG 100 μM and control group were transplanted under the kidney capsule of streptozotocin (STZ)-induced diabetic ICR mice.\nResults: The cell viability and insulin secretion ability in the EGCG group were preserved, and the nuclear translocation of Nrf2 was increased in the EGCG group (p<0.01). While the HO-1 mRNA levels were also higher in the EGCG group than in the control group (p<0.05), the ROS production was lower (p<0.01). An in vivo functional assessment showed that the blood glucose level had decreased in the EGCG group after transplantation (p<0.01).\nConclusion: EGCG protects the viability and function of islets by suppressing ROS production via the Nrf2 pathway.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer","subitem_publisher_language":"en"},{"subitem_publisher":"Japan Surgical Society","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"09411291","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"14362813","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10824685","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3342号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2019-12-26"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Atsushi Takataの学位論文として提出され，学位審査・授与の対象となっている。\nThis is a post-peer-review, pre-copyedit version of an article published in Surgery Today. The final authenticated version is available online at: https://doi.org/10.1007/s00595-019-1761-0\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1434号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1007/s00595-019-1761-0"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s00595-019-1761-0","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"361191"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"髙田, 厚史","creatorNameLang":"ja"},{"creatorName":"タカタ, アツシ","creatorNameLang":"ja-Kana"},{"creatorName":"Takata, 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transplantation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Reactive oxygen species (ROS)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Pre-conditioning","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Nuclear factor erythroid 2-related factor 2 (Nrf2)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Reactive oxygen species (ROS) production","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"The protective effect of epigallocatechin 3-gallate on mouse pancreatic islets via the Nrf2 pathway","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The protective effect of epigallocatechin 3-gallate on mouse pancreatic islets via the Nrf2 pathway","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-02-27"},"publish_date":"2020-02-27","publish_status":"0","recid":"2007125","relation_version_is_last":true,"title":["The protective effect of epigallocatechin 3-gallate on mouse pancreatic islets via the Nrf2 pathway"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-04-28T07:14:30.429249+00:00"}