{"created":"2024-10-30T09:02:59.055744+00:00","id":2007178,"links":{},"metadata":{"_buckets":{"deposit":"a7929310-d5b5-4ceb-a049-3f26a0795bfe"},"_deposit":{"created_by":7,"id":"2007178","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007178"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007178","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["564","340","231","197","183","309"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"DPP-4阻害薬であるビルダグリプチンは、非糖尿病アポリポタンパク質E欠損マウスの内皮機能障害と動脈硬化形成を軽減する","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"EFFECTS OF VILDAGLIPTIN ON ATHEROGENESIS","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-11-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"1429","bibliographicPageStart":"1421","bibliographicVolumeNumber":"60","bibliographic_titles":[{"bibliographic_title":"International Heart Journal","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Dipeptidyl peptidase-4 (DPP-4) inhibitors are novel antidiabetic agents with possible vascular protection effects. Endothelial dysfunction is an initiation step in atherogenesis. The purpose of this study was to investigate whether vildagliptin (Vilda) attenuates the development of endothelial dysfunction and atherosclerotic lesions in nondiabetic apolipoprotein E-deficient (ApoE−/−) mice. Eight-week-old nondiabetic ApoE−/− mice fed a Western-type diet received Vilda (50 mg/kg/day) for 20 weeks or 8 weeks. After 20 weeks of treatment, Vilda administration reduced atherogenesis in the aortic arch as determined by en face Sudan IV staining compared with the vehicle group (P < 0.05). Vilda also reduced lipid accumulation (P < 0.05) and vascular cell adhesion molecule-1 (VCAM-1) expression (P < 0.05) and tended to decrease macrophage infiltration (P = 0.05) into atherosclerotic plaques compared with vehicle. After 8 weeks of treatment, endothelium-dependent vascular reactivity was examined. Vilda administration significantly attenuated the impairment of endothelial function in nondiabetic ApoE−/− mice compared with the vehicle group (P < 0.05). Vilda treatment did not alter metabolic parameters, including blood glucose level, in both study protocols. To investigate the mechanism, aortic segments obtained from wild-type mice were incubated with exendin-4 (Ex-4), a glucagon-like peptide-1 (GLP-1) analog, in the presence or absence of lipopolysaccharide (LPS). Ex-4 attenuated the impairment of endothelium-dependent vasodilation induced by LPS (P < 0.01). Furthermore, Ex-4 promoted phosphorylation of eNOS at Ser1177 which was decreased by LPS in human umbilical endothelial cells (P < 0.05). Vilda inhibited the development of endothelial dysfunction and prevented atherogenesis in nondiabetic ApoE−/− mice. Our results suggested that GLP-1-dependent amelioration of endothelial dysfunction is associated with the atheroprotective effects of Vilda.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"International Heart Journal Association","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13493299","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3354号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Kunduziayi Ainiの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1437号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1536/ihj.19-117"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1536/ihj.19-117","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"360967"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"アイニ, クンドウズアイ","creatorNameLang":"ja"},{"creatorName":"アイニ, クンドウズアイ","creatorNameLang":"ja-Kana"},{"creatorName":"Aini, Kunduziayi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"福田, 大受","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"564","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"タナカ, キミエ","creatorNameLang":"ja"},{"creatorName":"タナカ, キミエ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanaka, Kimie","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヒガシクニ, ヤストミ","creatorNameLang":"ja"},{"creatorName":"ヒガシクニ, ヤストミ","creatorNameLang":"ja-Kana"},{"creatorName":"Higashikuni, Yasutomi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヒラタ, ヨウイチロウ","creatorNameLang":"ja"},{"creatorName":"ヒラタ, ヨウイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Hirata, Yoichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"八木, 秀介","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"340","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"楠瀬, 賢也","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"231","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田, 博胤","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"197","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"添木, 武","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"183","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐田, 政隆","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"309","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-04-16"}],"displaytype":"detail","filename":"k3354_abstract_review.pdf","filesize":[{"value":"191 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2007178/files/k3354_abstract_review.pdf"},"version_id":"d8576048-291a-4380-ab05-4b237dd7fea9"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-04-16"}],"displaytype":"detail","filename":"k3354_fulltext.pdf","filesize":[{"value":"730 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007178/files/k3354_fulltext.pdf"},"version_id":"aab4d601-1fef-49a4-9377-25414109c664"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Diabetes mellitus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Endothelial function","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Atherosclerosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"GLP-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Endothelial Dysfunction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"DPP-4 inhibitors","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Vildagliptin, a DPP-4 Inhibitor, Attenuates Endothelial Dysfunction and Atherogenesis in Nondiabetic Apolipoprotein E-Deficient Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Vildagliptin, a DPP-4 Inhibitor, Attenuates Endothelial Dysfunction and Atherogenesis in Nondiabetic Apolipoprotein E-Deficient Mice","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-02-17"},"publish_date":"2020-02-17","publish_status":"0","recid":"2007178","relation_version_is_last":true,"title":["Vildagliptin, a DPP-4 Inhibitor, Attenuates Endothelial Dysfunction and Atherogenesis in Nondiabetic Apolipoprotein E-Deficient Mice"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-30T09:03:09.162187+00:00"}