{"created":"2024-10-30T09:03:04.262400+00:00","id":2007179,"links":{},"metadata":{"_buckets":{"deposit":"d6b09569-df7e-4962-8447-487787bae071"},"_deposit":{"created_by":7,"id":"2007179","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007179"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007179","sets":["1713853213384:1713853296295:1716267877313:1716268556148"]},"author_link":["859","827","871","812","589"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"骨－歯根膜線維の複合組織形成による三次元的な歯周組織再生技術の開発","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-02-03","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"1656","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Scientific Reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Periodontal tissue is a distinctive tissue structure composed three-dimensionally of cementum, periodontal ligament (PDL) and alveolar bone. Severe periodontal diseases cause fundamental problems for oral function and general health, and conventional dental treatments are insufficient for healing to healthy periodontal tissue. Cell sheet technology has been used in many tissue regenerations, including periodontal tissue, to transplant appropriate stem/progenitor cells for tissue regeneration of a target site as a uniform tissue. However, it is still difficult to construct a three-dimensional structure of complex tissue composed of multiple types of cells, and the transplantation of a single cell sheet cannot sufficiently regenerate a large-scale tissue injury. Here, we fabricated a three-dimensional complex cell sheet composed of a bone-ligament structure by layering PDL cells and osteoblast-like cells on a temperature responsive culture dish. Following ectopic and orthotopic transplantation, only the complex cell sheet group was demonstrated to anatomically regenerate the bone-ligament structure along with the functional connection of PDL-like fibers to the tooth root and alveolar bone. This study represents successful three-dimensional tissue regeneration of a large-scale tissue injury using a bioengineered tissue designed to simulate the anatomical structure.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20452322","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3381号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開:\n内容要旨 : k3381_abstract.pdf\n審査要旨 : k3381_review.pdf\n論文本文 : k3381_fulltext.pdf (著者最終稿)\n論文本文 : srep_10_1656.pdf (雑誌掲載版)\n本論文は, 著者Resmi Rajuの学位論文として提出され, 学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院口腔科学教育部（口腔科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲口第460号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1038/s41598-020-58222-0"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s41598-020-58222-0","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"362695"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ラジュ, レスミ","creatorNameLang":"ja"},{"creatorName":"ラジュ, レスミ","creatorNameLang":"ja-Kana"},{"creatorName":"Raju, Resmi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"大島, 正充","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"859","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"井上, 美穂","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"827","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"守田, 剛","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"871","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Huijiao, Yan","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Waskitho, Arief","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"馬場, 麻人","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"812","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"イノウエ, マサヒサ","creatorNameLang":"ja"},{"creatorName":"イノウエ, マサヒサ","creatorNameLang":"ja-Kana"},{"creatorName":"Inoue, Masahisa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"松香, 芳三","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"589","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-02-17"}],"displaytype":"detail","filename":"srep_10_1656.pdf","filesize":[{"value":"4.96 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007179/files/srep_10_1656.pdf"},"version_id":"54c731a4-861d-4a99-9de4-4fce04fa2b47"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-04-16"}],"displaytype":"detail","filename":"k3381_abstract.pdf","filesize":[{"value":"180 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