{"created":"2024-10-30T09:05:07.256898+00:00","id":2007204,"links":{},"metadata":{"_buckets":{"deposit":"ccecf23f-ae95-4b09-8744-bec8b94a4473"},"_deposit":{"created_by":7,"id":"2007204","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007204"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007204","sets":["1713853213384:1713853296295:1716267878536:1716268699858"]},"author_link":["761","949","1578","1585","1583"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"ストレプトゾトシン誘導性糖尿病ラットにおける腎Cyp24a1遺伝子発現上昇と血漿1,25-ジヒドロキシビタミンD濃度低下との関連","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"56","bibliographicPageStart":"49","bibliographicVolumeNumber":"66","bibliographic_titles":[{"bibliographic_title":"Journal of Clinical Biochemistry and Nutrition","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Decreases in plasma vitamin D concentrations have been reported in diabetes, although the mechanism involved in this decrease is unclear. Here, we investigated the association between Cyp24a1, a vitamin D catabolic enzyme, and abnormalities in vitamin D metabolism in streptozotocin-induced diabetes rats, an animal model of type 1 diabetes. Plasma 1,25-dihydroxyvitamin D [1,25(OH)2D] levels were significantly lower in streptozotocin-induced diabetes rats and renal Cyp24a1 mRNA expression levels were increased. Western blotting analysis of streptozotocin-induced diabetes rats kidney tissues with anti-CYP24A1 antibody showed a strong signal around 40 kDa, which differs from the predicted 50–55 kDa molecular weight for full-length Cyp24a1 and could represent the Cyp24a1-splicing variant that lacks exons 1 and 2. We observed high levels of renal Cyp24a1-splicing variant mRNA expression in streptozotocin-induced diabetes rats. We also confirmed transcriptional up-regulation of endogenous Cyp24a1 mRNA expression through glucocorticoid receptors by glucocorticoid in opossum kidney proximal cells. Taken together, our results indicated that high Cyp24a1 expression levels may play a role in the decrease of plasma 1,25(OH)2D levels in streptozotocin-induced diabetes rats. High plasma corticosterone levels in diabetes may affect transcriptional regulation to promote increases in Cyp24a1 expression.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Society for Free Radical Research Japan","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2020 Society for Free Radical Research Japan","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"09120009","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"18805086","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10710201","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12091064","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3340号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(栄養学)","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2019-11-28"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は,著者Mari Tajiriの学位論文として提出され,学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院栄養生命科学教育部(人間栄養科学専攻)"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲栄第268号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3164/jcbn.19-79"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3164/jcbn.19-79","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"363850"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田尻, 真梨","creatorNameLang":"ja"},{"creatorName":"タジリ, マリ","creatorNameLang":"ja-Kana"},{"creatorName":"Tajiri, Mari","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ナカハシ, オトキ","creatorNameLang":"ja"},{"creatorName":"ナカハシ, オトキ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakahashi, Otoki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"香川, 知博","creatorNameLang":"ja"},{"creatorName":"カガワ, トモヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Kagawa, Tomohiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"増田, 真志","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"761","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大南, 博和","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"949","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"イワノ, マサユキ","creatorNameLang":"ja"},{"creatorName":"イワノ, マサユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Iwano, Masayuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"武田, 英二","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1578","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"竹谷, 豊","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1585","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山本, 浩範","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1583","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-02-26"}],"displaytype":"detail","filename":"k3340_abstract_review.pdf","filesize":[{"value":"261 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2007204/files/k3340_abstract_review.pdf"},"version_id":"3081c85e-62bd-4853-9ee7-295eaf32623d"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-02-26"}],"displaytype":"detail","filename":"k3340_fulltext.pdf","filesize":[{"value":"601 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007204/files/k3340_fulltext.pdf"},"version_id":"cd16c736-572a-40f2-a47f-a776584f2ec1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"vitamin D","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CYP24A1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CYP24A1-SV","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"diabetes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"streptozotocin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Association of increased renal Cyp24a1 gene expression with low plasma 1,25-dihydroxyvitamin D levels in rats with streptozotocin-induced diabetes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association of increased renal Cyp24a1 gene expression with low plasma 1,25-dihydroxyvitamin D levels in rats with streptozotocin-induced diabetes","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268699858"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-02-26"},"publish_date":"2020-02-26","publish_status":"0","recid":"2007204","relation_version_is_last":true,"title":["Association of increased renal Cyp24a1 gene expression with low plasma 1,25-dihydroxyvitamin D levels in rats with streptozotocin-induced diabetes"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-30T09:05:17.524544+00:00"}