{"created":"2024-10-30T09:05:12.037684+00:00","id":2007205,"links":{},"metadata":{"_buckets":{"deposit":"11c5d69b-6791-434b-bda8-8a2972af9025"},"_deposit":{"created_by":7,"id":"2007205","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007205"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007205","sets":["1713853213384:1713853296295:1716267878536:1716268699858"]},"author_link":["698","1430","329","1574","1584"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Na依存性PiトランスポーターNpt2cは、KlothoノックアウトマウスPi恒常性において成長期と成熟期では異なる作用を有する","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-02-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageStart":"e14324","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"Physiological Reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"SLC34A3/NPT2c/NaPi-2c/Npt2c is a growth-related NaPi cotransporter that mediates the uptake of renal sodium-dependent phosphate (Pi). Mutation of human NPT2c causes hereditary hypophosphatemic rickets with hypercalciuria. Mice with Npt2c knockout, however, exhibit normal Pi metabolism. To investigate the role of Npt2c in Pi homeostasis, we generated α-klotho−/−/Npt2c−/− (KL2cDKO) mice and analyzed Pi homeostasis. α-Klotho−/− (KLKO) mice exhibit hyperphosphatemia and markedly increased kidney Npt2c protein levels. Genetic disruption of Npt2c extended the lifespan of KLKO mice similar to that of α-Klotho−/−/Npt2a−/− mice. Adult KL2cDKO mice had hyperphosphatemia, but analysis of Pi metabolism revealed significantly decreased intestinal and renal Pi (re)absorption compared with KLKO mice. The 1,25-dihydroxy vitamin D3 concentration was not reduced in KL2cDKO mice compared with that in KLKO mice. The KL2cDKO mice had less severe soft tissue and vascular calcification compared with KLKO mice. Juvenile KL2cDKO mice had significantly reduced plasma Pi levels, but Pi metabolism was not changed. In Npt2cKO mice, plasma Pi levels began to decrease around the age of 15 days and significant hypophosphatemia developed within 21 days. The findings of the present study suggest that Npt2c contributes to regulating plasma Pi levels in the juvenile stage and affects Pi retention in the soft and vascular tissues in KLKO mice.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley","subitem_publisher_language":"en"},{"subitem_publisher":"The Physiological Society","subitem_publisher_language":"en"},{"subitem_publisher":"The American Physiological Society","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/ ), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"2051817X","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3346号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（栄養学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-01-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Ai Hanazakiの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院栄養生命科学教育部（人間栄養科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲栄第269号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.14814/phy2.14324"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.14814/phy2.14324","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"379922"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"花崎, 愛","creatorNameLang":"ja"},{"creatorName":"ハナザキ, アイ","creatorNameLang":"ja-Kana"},{"creatorName":"Hanazaki, Ai","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イクタ, カヨ","creatorNameLang":"ja"},{"creatorName":"イクタ, カヨ","creatorNameLang":"ja-Kana"},{"creatorName":"Ikuta, Kayo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ササキ, ショウヘイ","creatorNameLang":"ja"},{"creatorName":"ササキ, ショウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"Sasaki, Shohei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ササキ, スミレ","creatorNameLang":"ja"},{"creatorName":"ササキ, スミレ","creatorNameLang":"ja-Kana"},{"creatorName":"Sasaki, Sumire","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"コイケ, メグミ","creatorNameLang":"ja"},{"creatorName":"コイケ, メグミ","creatorNameLang":"ja-Kana"},{"creatorName":"Koike, Megumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タニフジ, カズヤ","creatorNameLang":"ja"},{"creatorName":"タニフジ, カズヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanifuji, Kazuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"アリマ, ユウキ","creatorNameLang":"ja"},{"creatorName":"アリマ, ユウキ","creatorNameLang":"ja-Kana"},{"creatorName":"Arima, Yuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"金子, 一郎","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"698","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"塩﨑, 雄治","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1430","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辰巳, 佐和子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"329","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ハセガワ, トモカ","creatorNameLang":"ja"},{"creatorName":"ハセガワ, トモカ","creatorNameLang":"ja-Kana"},{"creatorName":"Hasegawa, Tomoka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"アミヅカ, ノリオ","creatorNameLang":"ja"},{"creatorName":"アミヅカ, ノリオ","creatorNameLang":"ja-Kana"},{"creatorName":"Amizuka, Norio","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"宮本, 賢一","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1574","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"瀬川, 博子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1584","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-02-12"}],"displaytype":"detail","filename":"k3346_abstract_review.pdf","filesize":[{"value":"225 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2007205/files/k3346_abstract_review.pdf"},"version_id":"332c8a5e-104e-4f12-b5a7-409dbfea36d6"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-02-12"}],"displaytype":"detail","filename":"k3346_fulltext.pdf","filesize":[{"value":"2.29 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007205/files/k3346_fulltext.pdf"},"version_id":"05c390a4-8188-43a8-9394-29f90bc92f5c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Phosphate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"klotho","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Npt2c","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HHRH","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"juvenile","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"FGF23/klotho","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"growth","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"intestine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"kidney","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"phosphate transporter","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Role of sodium-dependent Pi transporter/Npt2c on Pi homeostasis in klotho knockout mice different properties between juvenile and adult stages","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Role of sodium-dependent Pi transporter/Npt2c on Pi homeostasis in klotho knockout mice different properties between juvenile and adult stages","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268699858"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-02-12"},"publish_date":"2020-02-12","publish_status":"0","recid":"2007205","relation_version_is_last":true,"title":["Role of sodium-dependent Pi transporter/Npt2c on Pi homeostasis in klotho knockout mice different properties between juvenile and adult stages"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-30T09:05:22.432838+00:00"}