{"created":"2024-10-30T09:08:23.027029+00:00","id":2007248,"links":{},"metadata":{"_buckets":{"deposit":"50d67d71-7cd4-43a9-8089-d7f5ef8a44a8"},"_deposit":{"created_by":7,"id":"2007248","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007248"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007248","sets":["1713853213384:1713853295607"]},"author_link":["598","286","1586","377","323"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Myostatin-Targeting siRNA and ActRIIB-Fc Fusion Protein","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-10-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"248","bibliographicPageStart":"244","bibliographicVolumeNumber":"63","bibliographic_titles":[{"bibliographic_title":"Journal of Nutritional Science and Vitaminology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Myostatin, a member of the TGF-β superfamily, is a negative regulator of skeletal muscle cell growth and differentiation, and binds with high affinity to the activin type IIB receptor (ActRIIB). The soluble ligand-binding domain of ActRIIB fused to the Fc domain of IgG (ActRIIB-Fc) potently binds and inhibits TGF-β family members in muscle, leading to rapid and marked muscle growth. The present study was designed to assess the effectiveness of the co-delivery of myostatin-targeting siRNA (Mstn-siRNA) and ActRIIB-Fc into skeletal muscle as a potential treatment of atrophic myopathies. Eleven-week-old, male C57BL/6 mice were injected with atelocollagen (ATCOL)-mediated Mstn-siRNA with/without ActRIIB-Fc locally into the masseter muscle twice a week. Inhibition of myostatin function by the combination of Mstn-siRNA and ActRIIB-Fc increased muscle weight and myofibril size in murine masseter muscle. Real-time RT-PCR analysis revealed significant downregulation of myostatin mRNA expression in both the Mstn-siRNA-treated and the combination treatment group. Furthermore, myogenin mRNA expression was upregulated in the combination treatment group, while MuRF-1 and Atrogin-1 mRNA expression was downregulated compared to administration of each compound alone. These findings suggest that double inhibition of myostatin is a potentially useful treatment strategy to increase muscle mass and fiber size and could be a useful treatment of patients with various muscle atrophies, including muscular dystrophy.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Vitamin Society of Japan","subitem_publisher_language":"en"},{"subitem_publisher":"Japan Society of Nutrition and Food Science","subitem_publisher_language":"en"},{"subitem_publisher":"Center for Academic Publications Japan","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© The Vitamin Society of Japan, Japan Society of Nutrition and Food Science\n本文データは学協会の許諾に基づきCiNiiから複製したものである\nhttps://ci.nii.ac.jp/naid/130007314434","subitem_rights_language":"ja"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"03014800","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"18817742","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00703822","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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