{"created":"2024-10-30T09:09:16.603544+00:00","id":2007259,"links":{},"metadata":{"_buckets":{"deposit":"a521ded4-116a-452c-a22c-91390cd16dae"},"_deposit":{"created_by":7,"id":"2007259","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007259"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007259","sets":["1713853213384:1713853295607"]},"author_link":["632","388"],"control_number":"2007259","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageStart":"63","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"Brain Sciences","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease caused by the expansion of a CAG trinucleotide repeat encoding an abnormally long polyglutamine tract (PolyQ) in the huntingtin (Htt) protein. In HD, striking neuropathological changes occur in the striatum, including loss of medium spiny neurons and parvalbumin-expressing interneurons accompanied by neurodegeneration of the striosome and matrix compartments, leading to progressive impairment of reasoning, walking and speaking abilities. The precise cause of striatal pathology in HD is still unknown; however, accumulating clinical and experimental evidence suggests multiple plausible pathophysiological mechanisms underlying striatal neurodegeneration in HD. Here, we review and discuss the characteristic neurodegenerative patterns observed in the striatum of HD patients and consider the role of various huntingtin-related and striatum-enriched proteins in neurotoxicity and neuroprotection.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20763425","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3390/brainsci7060063"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/brainsci7060063","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"325981"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"森垣, 龍馬","creatorNameLang":"ja"},{"creatorName":"モリガキ, リョウマ","creatorNameLang":"ja-Kana"},{"creatorName":"Morigaki, Ryoma","creatorNameLang":"en"}],"familyNames":[{"familyName":"森垣","familyNameLang":"ja"},{"familyName":"モリガキ","familyNameLang":"ja-Kana"},{"familyName":"Morigaki","familyNameLang":"en"}],"givenNames":[{"givenName":"龍馬","givenNameLang":"ja"},{"givenName":"リョウマ","givenNameLang":"ja-Kana"},{"givenName":"Ryoma","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"632","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"261538/profile-ja.html","nameIdentifierScheme":"徳島大学 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Satoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"後藤","familyNameLang":"ja"},{"familyName":"ゴトウ","familyNameLang":"ja-Kana"},{"familyName":"Goto","familyNameLang":"en"}],"givenNames":[{"givenName":"惠","givenNameLang":"ja"},{"givenName":"サトシ","givenNameLang":"ja-Kana"},{"givenName":"Satoshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"388","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50240916","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=50240916"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-03-12"}],"displaytype":"detail","filename":"brainsci_7_6_63.pdf","filesize":[{"value":"1.02 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007259/files/brainsci_7_6_63.pdf"},"version_id":"6b30d593-1895-4dfa-85f6-c277786d5264"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Huntington’s disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"huntingtin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"striatum","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"medium spiny neuron","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pathophysiology","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"striosome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"matrix","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Striatal Vulnerability in Huntington’s Disease : Neuroprotection Versus Neurotoxicity","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Striatal Vulnerability in Huntington’s Disease : Neuroprotection Versus Neurotoxicity","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-03-12"},"publish_date":"2020-03-12","publish_status":"0","recid":"2007259","relation_version_is_last":true,"title":["Striatal Vulnerability in Huntington’s Disease : Neuroprotection Versus Neurotoxicity"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-28T01:31:24.989551+00:00"}