{"created":"2024-10-30T09:11:23.476213+00:00","id":2007286,"links":{},"metadata":{"_buckets":{"deposit":"bca5f10a-100a-4aa6-9cc8-96aef8a733f4"},"_deposit":{"created_by":7,"id":"2007286","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007286"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007286","sets":["1713853213384:1713853295607"]},"author_link":["883"],"control_number":"2007286","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Clarithromycin expands CD11b+Gr-1+ MDSC-like cells","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-04-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageStart":"e1006955","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"PLOS Pathogens","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Macrolides are used to treat various inflammatory diseases owing to their immunomodulatory properties; however, little is known about their precise mechanism of action. In this study, we investigated the functional significance of the expansion of myeloid-derived suppressor cell (MDSC)-like CD11b+Gr-1+ cells in response to the macrolide antibiotic clarithromycin (CAM) in mouse models of shock and post-influenza pneumococcal pneumonia as well as in humans. Intraperitoneal administration of CAM markedly expanded splenic and lung CD11b+Gr-1+ cell populations in naïve mice. Notably, CAM pretreatment enhanced survival in a mouse model of lipopolysaccharide (LPS)-induced shock. In addition, adoptive transfer of CAM-treated CD11b+Gr-1+ cells protected mice against LPS-induced lethality via increased IL-10 expression. CAM also improved survival in post-influenza, CAM-resistant pneumococcal pneumonia, with improved lung pathology as well as decreased interferon (IFN)-γ and increased IL-10 levels. Adoptive transfer of CAM-treated CD11b+Gr-1+ cells protected mice from post-influenza pneumococcal pneumonia. Further analysis revealed that the CAM-induced CD11b+Gr-1+ cell expansion was dependent on STAT3-mediated Bv8 production and may be facilitated by the presence of gut commensal microbiota. Lastly, an analysis of peripheral blood obtained from healthy volunteers following oral CAM administration showed a trend toward the expansion of human MDSC-like cells (Lineage−HLA-DR−CD11b+CD33+) with increased arginase 1 mRNA expression. Thus, CAM promoted the expansion of a unique population of immunosuppressive CD11b+Gr-1+ cells essential for the immunomodulatory properties of macrolides.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"PLOS","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2018 Namkoong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"15537366","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"15537374","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1371/journal.ppat.1006955"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1371/journal.ppat.1006955","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"344210"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Namkoong, Ho","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イシイ, マコト","creatorNameLang":"ja"},{"creatorName":"イシイ, マコト","creatorNameLang":"ja-Kana"},{"creatorName":"Ishii, Makoto","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"藤猪, 英樹","creatorNameLang":"ja"},{"creatorName":"フジイ, ヒデキ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujii, Hideki","creatorNameLang":"en"}],"familyNames":[{"familyName":"藤猪","familyNameLang":"ja"},{"familyName":"フジイ","familyNameLang":"ja-Kana"},{"familyName":"Fujii","familyNameLang":"en"}],"givenNames":[{"givenName":"英樹","givenNameLang":"ja"},{"givenName":"ヒデキ","givenNameLang":"ja-Kana"},{"givenName":"Hideki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"883","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"325429/profile-ja.html","nameIdentifierScheme":"徳島大学 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Ahmed E.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カマタ, ヒロフミ","creatorNameLang":"ja"},{"creatorName":"カマタ, ヒロフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Kamata, Hirofumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タサカ, サダトモ","creatorNameLang":"ja"},{"creatorName":"タサカ, サダトモ","creatorNameLang":"ja-Kana"},{"creatorName":"Tasaka, Sadatomo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"アタラシ, コウジ","creatorNameLang":"ja"},{"creatorName":"アタラシ, コウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Atarashi, Koji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ナカモト, ノブヒロ","creatorNameLang":"ja"},{"creatorName":"ナカモト, ノブヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakamoto, Nobuhiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イワタ, サトシ","creatorNameLang":"ja"},{"creatorName":"イワタ, サトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Iwata, Satoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ホンダ, 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