{"created":"2024-10-30T09:13:28.808800+00:00","id":2007312,"links":{},"metadata":{"_buckets":{"deposit":"e400d455-13a8-4818-93f4-2f5358a2e669"},"_deposit":{"created_by":7,"id":"2007312","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007312"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007312","sets":["1713853213384:1713853295607"]},"author_link":["1542"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-08-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"e000325","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"BMJ Open Respiratory Research","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Introduction A feature of the pathogenesis of idiopathic pulmonary fibrosis (IPF) is the excess accumulation of extracellular matrix (ECM) in the lungs. Cleavage of the ECM by metalloproteinases (MMPs) generates freecirculating protein fragments known as neoepitopes. The PROFILE study suggested that changes in ECM turnover proteins may be of value as markers of disease progression in patients with IPF. Nintedanib is an approved treatment for IPF that slows disease progression by reducing decline in forced vital capacity (FVC).\nMethods and analysis The INMARK® trial is evaluating the effect of nintedanib on the rates of change of biomarkers of ECM turnover in patients with IPF, the value of changes in these biomarkers as predictors of disease progression and whether nintedanib affects the associations between changes in these biomarkers and disease progression. Following a screening period, 347 patients with IPF and FVC ≥80% predicted were randomised 1:2 to receive nintedanib 150 mg two times a day or placebo for 12 weeks, followed by an open-label period in which all patients will receive nintedanib for 40 weeks. The primary endpoint is the rate of change in C reactive protein degraded by MMP-1/8 from baseline to week 12.\nEthics and dissemination This trial is being conducted in compliance with the protocol, the ethical principles detailed in the Declaration of Helsinki and in accordance with the International Conference on Harmonisation Harmonised Tripartite Guideline for Good Clinical Practice. The results of the trial will be presented at national and international meetings and published in peer-reviewed journals.\nTrial registration number NCT02788474","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BMJ Publishing Group","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an Open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20524439","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"Trial registration number: NCT02788474 ( https://clinicaltrials.gov/ct2/show/NCT02788474 )"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1136/bmjresp-2018-000325"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1136/bmjresp-2018-000325","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"347647"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Maher, Toby M","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Stowasser, Susanne","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"西岡, 安彦","creatorNameLang":"ja"},{"creatorName":"ニシオカ, ヤスヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Nishioka, Yasuhiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"西岡","familyNameLang":"ja"},{"familyName":"ニシオカ","familyNameLang":"ja-Kana"},{"familyName":"Nishioka","familyNameLang":"en"}],"givenNames":[{"givenName":"安彦","givenNameLang":"ja"},{"givenName":"ヤスヒコ","givenNameLang":"ja-Kana"},{"givenName":"Yasuhiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1542","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60062/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60062/profile-ja.html"},{"nameIdentifier":"70274199","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70274199"}]},{"creatorNames":[{"creatorName":"White, Eric S","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Cottin, Vincent","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Noth, Imre","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Selman, Moisés","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Blahova, Zuzana","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Wachtlin, Daniel","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Diefenbach, Claudia","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Jenkins, R Gisli","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-03-19"}],"displaytype":"detail","filename":"BMJResp_5_1_e000325.pdf","filesize":[{"value":"546 KB"}],"format":"application/pdf","licensetype":"license_3","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007312/files/BMJResp_5_1_e000325.pdf"},"version_id":"5d1e10c0-39bd-47b3-9185-473c439fac02"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Investigating the effects of nintedanib on biomarkers of extracellular matrix turnover in patients with IPF : design of the randomised placebo-controlled INMARK®trial","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Investigating the effects of nintedanib on biomarkers of extracellular matrix turnover in patients with IPF : design of the randomised placebo-controlled INMARK®trial","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-03-19"},"publish_date":"2020-03-19","publish_status":"0","recid":"2007312","relation_version_is_last":true,"title":["Investigating the effects of nintedanib on biomarkers of extracellular matrix turnover in patients with IPF : design of the randomised placebo-controlled INMARK®trial"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-28T07:07:20.591377+00:00"}