{"created":"2024-10-30T09:15:00.941568+00:00","id":2007332,"links":{},"metadata":{"_buckets":{"deposit":"77dfc325-db69-40c9-9117-fa55b5c5868e"},"_deposit":{"created_by":7,"id":"2007332","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007332"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007332","sets":["1713853213384:1713853295607"]},"author_link":["573","838","1623","1447","530","1622","1208"],"control_number":"2007332","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-07-18","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"168","bibliographicVolumeNumber":"19","bibliographic_titles":[{"bibliographic_title":"BMC Neurology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: The coexistence of distinct neurodegenerative diseases in single cases has recently attracted greater attention. The phenotypic co-occurrence of progressive supranuclear palsy (PSP) and amyotrophic lateral sclerosis (ALS) has been documented in several cases. That said, the clinicopathological comorbidity of these two diseases has not been demonstrated.\nCase presentation: A 77-year-old man presented with gait disturbance for 2 years, consistent with PSP with progressive gait freezing. At 79 years old, he developed muscle weakness compatible with ALS. The disease duration was 5 years after the onset of PSP and 5months after the onset of ALS. Neuropathological findings demonstrated the coexistence of PSP and ALS. Immunohistochemical examination confirmed 4-repeat tauopathy, including globose-type neurofibrillary tangles, tufted astrocytes, and oligodendroglial coiled bodies as well as TAR DNA-binding protein 43 kDa pathology in association with upper and lower motor neuron degeneration. Immunoblotting showed hyperphosphorylated full-length 4-repeat tau bands (64 and 68 kDa) and C-terminal fragments (33 kDa), supporting the diagnosis of PSP and excluding other parkinsonian disorders, such as corticobasal degeneration. Genetic studies showed no abnormalities in genes currently known to be related to ALS or PSP.\nConclusions: Our case demonstrates the clinicopathological comorbidity of PSP and ALS in a sporadic patient. The possibility of multiple proteinopathies should be considered when distinct symptoms develop during the disease course.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"},{"subitem_publisher":"BioMed Central","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14712377","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12035325","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1186/s12883-019-1402-7"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1186/s12883-019-1402-7","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"356565"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"藤田, 浩司","creatorNameLang":"ja"},{"creatorName":"フジタ, コウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujita, Kouji","creatorNameLang":"en"}],"familyNames":[{"familyName":"藤田","familyNameLang":"ja"},{"familyName":"フジタ","familyNameLang":"ja-Kana"},{"familyName":"Fujita","familyNameLang":"en"}],"givenNames":[{"givenName":"浩司","givenNameLang":"ja"},{"givenName":"コウジ","givenNameLang":"ja-Kana"},{"givenName":"Kouji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"573","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"246775/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/246775/profile-ja.html"},{"nameIdentifier":"80601765","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80601765"}]},{"creatorNames":[{"creatorName":"マツバラ, トモヤス","creatorNameLang":"ja"},{"creatorName":"マツバラ, トモヤス","creatorNameLang":"ja-Kana"},{"creatorName":"Matsubara, Tomoyasu","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"宮本, 亮介","creatorNameLang":"ja"},{"creatorName":"ミヤモト, リョウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyamoto, Ryosuke","creatorNameLang":"en"}],"familyNames":[{"familyName":"宮本","familyNameLang":"ja"},{"familyName":"ミヤモト","familyNameLang":"ja-Kana"},{"familyName":"Miyamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"亮介","givenNameLang":"ja"},{"givenName":"リョウスケ","givenNameLang":"ja-Kana"},{"givenName":"Ryosuke","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"838","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"313548/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/313548/profile-ja.html"}]},{"creatorNames":[{"creatorName":"スミクラ, ヒロユキ","creatorNameLang":"ja"},{"creatorName":"スミクラ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Sumikura, Hiroyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タケウチ, トシアキ","creatorNameLang":"ja"},{"creatorName":"タケウチ, トシアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Takeuchi, Toshiaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マルヤマ, ケイコ","creatorNameLang":"ja"},{"creatorName":"マルヤマ, ケイコ","creatorNameLang":"ja-Kana"},{"creatorName":"Maruyama Saladini, Keiko","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"瓦井, 俊孝","creatorNameLang":"ja"},{"creatorName":"カワライ, トシタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawarai, Toshitaka","creatorNameLang":"en"}],"familyNames":[{"familyName":"瓦井","familyNameLang":"ja"},{"familyName":"カワライ","familyNameLang":"ja-Kana"},{"familyName":"Kawarai","familyNameLang":"en"}],"givenNames":[{"givenName":"俊孝","givenNameLang":"ja"},{"givenName":"トシタカ","givenNameLang":"ja-Kana"},{"givenName":"Toshitaka","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"530","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50614137","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=50614137"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"野寺, 裕之","creatorNameLang":"ja"},{"creatorName":"ノデラ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Nodera, Hiroyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"野寺","familyNameLang":"ja"},{"familyName":"ノデラ","familyNameLang":"ja-Kana"},{"familyName":"Nodera","familyNameLang":"en"}],"givenNames":[{"givenName":"裕之","givenNameLang":"ja"},{"givenName":"ヒロユキ","givenNameLang":"ja-Kana"},{"givenName":"Hiroyuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1208","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40363147","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40363147"}]},{"creatorNames":[{"creatorName":"ウダカ, フカシ","creatorNameLang":"ja"},{"creatorName":"ウダカ, フカシ","creatorNameLang":"ja-Kana"},{"creatorName":"Udaka, Fukashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"クメ, コウダイ","creatorNameLang":"ja"},{"creatorName":"クメ, コウダイ","creatorNameLang":"ja-Kana"},{"creatorName":"Kume, Kodai","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"森野, 豊之","creatorNameLang":"ja"},{"creatorName":"モリノ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Morino, Hiroyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"森野","familyNameLang":"ja"},{"familyName":"モリノ","familyNameLang":"ja-Kana"},{"familyName":"Morino","familyNameLang":"en"}],"givenNames":[{"givenName":"豊之","givenNameLang":"ja"},{"givenName":"ヒロユキ","givenNameLang":"ja-Kana"},{"givenName":"Hiroyuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1447","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"376094/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/376094/profile-ja.html"},{"nameIdentifier":"10397953","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10397953"}]},{"creatorNames":[{"creatorName":"カワカミ, ヒデシ","creatorNameLang":"ja"},{"creatorName":"カワカミ, ヒデシ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawakami, Hideshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハセガワ, マサト","creatorNameLang":"ja"},{"creatorName":"ハセガワ, マサト","creatorNameLang":"ja-Kana"},{"creatorName":"Hasegawa, Masato","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"梶, 龍兒","creatorNameLang":"ja"},{"creatorName":"カジ, リュウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Kaji, Ryuji","creatorNameLang":"en"}],"familyNames":[{"familyName":"梶","familyNameLang":"ja"},{"familyName":"カジ","familyNameLang":"ja-Kana"},{"familyName":"Kaji","familyNameLang":"en"}],"givenNames":[{"givenName":"龍兒","givenNameLang":"ja"},{"givenName":"リュウジ","givenNameLang":"ja-Kana"},{"givenName":"Ryuji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1622","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60224/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60224/profile-ja.html"},{"nameIdentifier":"00214304","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=00214304"}]},{"creatorNames":[{"creatorName":"ムラヤマ, シゲオ","creatorNameLang":"ja"},{"creatorName":"ムラヤマ, シゲオ","creatorNameLang":"ja-Kana"},{"creatorName":"Murayama, Shigeo","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"和泉, 唯信","creatorNameLang":"ja"},{"creatorName":"イズミ, ユイシン","creatorNameLang":"ja-Kana"},{"creatorName":"Izumi, Yuishin","creatorNameLang":"en"}],"familyNames":[{"familyName":"和泉","familyNameLang":"ja"},{"familyName":"イズミ","familyNameLang":"ja-Kana"},{"familyName":"Izumi","familyNameLang":"en"}],"givenNames":[{"givenName":"唯信","givenNameLang":"ja"},{"givenName":"ユイシン","givenNameLang":"ja-Kana"},{"givenName":"Yuishin","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1623","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60227/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60227/profile-ja.html"},{"nameIdentifier":"10335812","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10335812"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-03-26"}],"displaytype":"detail","filename":"BMCNeuro_19_168.pdf","filesize":[{"value":"1.54 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007332/files/BMCNeuro_19_168.pdf"},"version_id":"9937253b-bf88-4993-81ce-f88c30a9b4f4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Amyotrophic lateral sclerosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Progressive supranuclear palsy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"TAR DNA-binding protein 43 kDa (TDP-43)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tau","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Copathology","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Co-morbidity of progressive supranuclear palsy and amyotrophic lateral sclerosis : a clinical-pathological case report","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Co-morbidity of progressive supranuclear palsy and amyotrophic lateral sclerosis : a clinical-pathological case report","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-03-26"},"publish_date":"2020-03-26","publish_status":"0","recid":"2007332","relation_version_is_last":true,"title":["Co-morbidity of progressive supranuclear palsy and amyotrophic lateral sclerosis : a clinical-pathological case report"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-04-28T06:32:51.607503+00:00"}