{"created":"2024-10-30T09:16:34.622439+00:00","id":2007352,"links":{},"metadata":{"_buckets":{"deposit":"f79f8ab3-a0e3-438a-8c7f-0cf40a699ab6"},"_deposit":{"created_by":7,"id":"2007352","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007352"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007352","sets":["1713853213384:1713853295607"]},"author_link":["536","892","796","1631","1564","1589"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-02-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"321","bibliographicPageStart":"315","bibliographicVolumeNumber":"42","bibliographic_titles":[{"bibliographic_title":"Brain and Development","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Introduction\nArterial spin labeling (ASL) is a non-invasive magnetic resonance imaging (MRI) technique that can measure regional cerebral blood flow (rCBF) without radiation exposure. This study aimed to evaluate rCBF in individuals with autism and their age-matched controls, globally and regionally.\n\nMethods\nWe performed ASL MRI (3T, pulsed-continuous ASL, 3 delayed ASL imaging sequences) for 33 patients with autism spectrum disorder (ASD) (average age: 7.3 years, range: 2-14 years). Nineteen children (average age: 8.6 years, range: 3-15 years) without ASD and intellectual delay were included as controls. Patients with morphological abnormalities detected on MRI were excluded. Objective analysis was performed with automatic region of interest analysis of the ASL results. The Mann-Whitney U test was used to compare the rCBF results between the groups.\n\nResults\nCompared to the controls, patients with ASD showed a statistically significant decrease in rCBF, respectively, in the insula [left, rCBF 51.8±9.5 mL/100 g/min (mean±SD) versus 59.9±9.8, p=0.0017; right, 51.2±10.1 versus 57.8±8.8, p=0.0354], superior parietal lobule (left, 44.6±8.4 versus 52.0±7.8, p=0.003), superior temporal gyrus (left, 50.0±8.6 versus 56.9±8.6, p=0.007; right, 49.5±8.4 versus 56.4±7.7, p=0.0058), and inferior frontal gyrus (left, 53.0±9.8 versus 59.3±9.9, p=0.0279), which are associated with the mirror neuron system.\n\nConclusions\nWe concluded that patients with ASD showed a statistically significant decline in CBF in regions associated with the mirror neuron system. The advantages of ASL MRI include low invasiveness (no radiation exposure) and short imaging time (approximately 5 min). Studies with larger sample sizes are required to establish the diagnostic value of ASL MRI for ASD.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Japanese Society of Child Neurology","subitem_publisher_language":"en"},{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"03877604","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00111153","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA11521714","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.braindev.2020.01.007"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.braindev.2020.01.007","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"363539"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"森, 達夫","creatorNameLang":"ja"},{"creatorName":"モリ, タツオ","creatorNameLang":"ja-Kana"},{"creatorName":"Mori, Tatsuo","creatorNameLang":"en"}],"familyNames":[{"familyName":"森","familyNameLang":"ja"},{"familyName":"モリ","familyNameLang":"ja-Kana"},{"familyName":"Mori","familyNameLang":"en"}],"givenNames":[{"givenName":"達夫","givenNameLang":"ja"},{"givenName":"タツオ","givenNameLang":"ja-Kana"},{"givenName":"Tatsuo","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"796","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"294224/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/294224/profile-ja.html"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"伊藤, 弘道","creatorNameLang":"ja"},{"creatorName":"イトウ, ヒロミチ","creatorNameLang":"ja-Kana"},{"creatorName":"Ito, Hiromichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"伊藤","familyNameLang":"ja"},{"familyName":"イトウ","familyNameLang":"ja-Kana"},{"familyName":"Ito","familyNameLang":"en"}],"givenNames":[{"givenName":"弘道","givenNameLang":"ja"},{"givenName":"ヒロミチ","givenNameLang":"ja-Kana"},{"givenName":"Hiromichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"536","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10398018","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10398018"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"原田, 雅史","creatorNameLang":"ja"},{"creatorName":"ハラダ, マサフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Harada, Masafumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"原田","familyNameLang":"ja"},{"familyName":"ハラダ","familyNameLang":"ja-Kana"},{"familyName":"Harada","familyNameLang":"en"}],"givenNames":[{"givenName":"雅史","givenNameLang":"ja"},{"givenName":"マサフミ","givenNameLang":"ja-Kana"},{"givenName":"Masafumi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1589","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60159/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60159/profile-ja.html"},{"nameIdentifier":"20228654","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=20228654"}]},{"creatorNames":[{"creatorName":"ヒサオカ, ソノカ","creatorNameLang":"ja"},{"creatorName":"ヒサオカ, ソノカ","creatorNameLang":"ja-Kana"},{"creatorName":"Hisaoka, Sonoka","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"松元, 友暉","creatorNameLang":"ja"},{"creatorName":"マツモト, ユウキ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsumoto, Yuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"松元","familyNameLang":"ja"},{"familyName":"マツモト","familyNameLang":"ja-Kana"},{"familyName":"Matsumoto","familyNameLang":"en"}],"givenNames":[{"givenName":"友暉","givenNameLang":"ja"},{"givenName":"ユウキ","givenNameLang":"ja-Kana"},{"givenName":"Yuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"892","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"327872/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/327872/profile-ja.html"}]},{"creatorNames":[{"creatorName":"郷司, 彩","creatorNameLang":"ja"},{"creatorName":"ゴウジ, アヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Goji, Aya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"トダ, ヨシヒロ","creatorNameLang":"ja"},{"creatorName":"トダ, ヨシヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Toda, Yoshihiro","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"森, 健治","creatorNameLang":"ja"},{"creatorName":"モリ, ケンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Mori, Kenji","creatorNameLang":"en"}],"familyNames":[{"familyName":"森","familyNameLang":"ja"},{"familyName":"モリ","familyNameLang":"ja-Kana"},{"familyName":"Mori","familyNameLang":"en"}],"givenNames":[{"givenName":"健治","givenNameLang":"ja"},{"givenName":"ケンジ","givenNameLang":"ja-Kana"},{"givenName":"Kenji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1564","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60104/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60104/profile-ja.html"},{"nameIdentifier":"20274201","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=20274201"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"香美, 祥二","creatorNameLang":"ja"},{"creatorName":"カガミ, ショウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Kagami, Shoji","creatorNameLang":"en"}],"familyNames":[{"familyName":"香美","familyNameLang":"ja"},{"familyName":"カガミ","familyNameLang":"ja-Kana"},{"familyName":"Kagami","familyNameLang":"en"}],"givenNames":[{"givenName":"祥二","givenNameLang":"ja"},{"givenName":"ショウジ","givenNameLang":"ja-Kana"},{"givenName":"Shoji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1631","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60248/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60248/profile-ja.html"},{"nameIdentifier":"224337","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=224337"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-02-20"}],"displaytype":"detail","filename":"braindev_42_4_315.pdf","filesize":[{"value":"1.54 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007352/files/braindev_42_4_315.pdf"},"version_id":"49474f8f-502b-4ad6-8e64-31f4c93f55a6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Arterial spin labeling","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Autism spectrum disorder","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cerebral blood flow","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Magnetic resonance imaging","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mirror neuron system","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Multi-delay arterial spin labeling brain magnetic resonance imaging study for pediatric autism","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Multi-delay arterial spin labeling brain magnetic resonance imaging study for pediatric autism","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-04-16"},"publish_date":"2020-04-16","publish_status":"0","recid":"2007352","relation_version_is_last":true,"title":["Multi-delay arterial spin labeling brain magnetic resonance imaging study for pediatric autism"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T13:10:48.062040+00:00"}