{"created":"2024-10-30T09:16:53.218481+00:00","id":2007356,"links":{},"metadata":{"_buckets":{"deposit":"9ff31692-1a57-492c-a9d3-87628a17e929"},"_deposit":{"created_by":7,"id":"2007356","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007356"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007356","sets":["1713853213384:1713853295607"]},"author_link":["1648","1264"],"control_number":"2007356","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"AIP Mutation-positive Pituitary Tumors","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-01-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageStart":"dgaa040","bibliographicVolumeNumber":"105","bibliographic_titles":[{"bibliographic_title":"The Journal of Clinical Endocrinology & Metabolism","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Context: Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are responsible for a subset of familial isolated pituitary adenoma (FIPA) cases and sporadic pituitary neuroendocrine tumors (PitNETs).\nObjective: To compare prospectively diagnosed AIP mutation-positive (AIPmut) PitNET patients with clinically presenting patients and to compare the clinical characteristics of AIPmut and AIPneg PitNET patients.\nDesign: 12-year prospective, observational study.\nParticipants & Setting: We studied probands and family members of FIPA kindreds and sporadic patients with disease onset ≤18 years or macroadenomas with onset ≤30 years (n = 1477). This was a collaborative study conducted at referral centers for pituitary diseases.\nInterventions & Outcome: AIP testing and clinical screening for pituitary disease. Comparison of characteristics of prospectively diagnosed (n = 22) vs clinically presenting AIPmut PitNET patients (n = 145), and AIPmut (n = 167) vs AIPneg PitNET patients (n = 1310).\nResults: Prospectively diagnosed AIPmut PitNET patients had smaller lesions with less suprasellar extension or cavernous sinus invasion and required fewer treatments with fewer operations and no radiotherapy compared with clinically presenting cases; there were fewer cases with active disease and hypopituitarism at last follow-up. When comparing AIPmut and AIPneg cases, AIPmut patients were more often males, younger, more often had GH excess, pituitary apoplexy, suprasellar extension, and more patients required multimodal therapy, including radiotherapy. AIPmut patients (n = 136) with GH excess were taller than AIPneg counterparts (n = 650).\nConclusions: Prospectively diagnosed AIPmut patients show better outcomes than clinically presenting cases, demonstrating the benefits of genetic and clinical screening. AIP-related pituitary disease has a wide spectrum ranging from aggressively growing lesions to stable or indolent disease course.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Endocrine Society","subitem_publisher_language":"en"},{"subitem_publisher":"Oxford University Press","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"0021972X","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"19457197","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00695484","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA1203774X","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"Collaborators : Members of the FIPA consortium are listed at http://www.fipapatients.org/fipaconsortium/."}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1210/clinem/dgaa040"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1210/clinem/dgaa040","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"363551"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Marques, Pedro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Caimari, Francisca","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hernández-Ramírez, Laura C.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Collier, David","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Iacovazzo, Donato","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ronaldson, Amy","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Magid, Kesson","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Lim, Chung Thong","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Stals, Karen","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ellard, Sian","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Grossman, Ashley B.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Korbonits, Márta","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"岩田, 武男","creatorNameLang":"ja"},{"creatorName":"イワタ, タケオ","creatorNameLang":"ja-Kana"},{"creatorName":"Iwata, Takeo","creatorNameLang":"en"}],"familyNames":[{"familyName":"岩田","familyNameLang":"ja"},{"familyName":"イワタ","familyNameLang":"ja-Kana"},{"familyName":"Iwata","familyNameLang":"en"}],"givenNames":[{"givenName":"武男","givenNameLang":"ja"},{"givenName":"タケオ","givenNameLang":"ja-Kana"},{"givenName":"Takeo","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1264","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10350399","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10350399"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"吉本, 勝彦","creatorNameLang":"ja"},{"creatorName":"ヨシモト, カツヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshimoto, Katsuhiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"吉本","familyNameLang":"ja"},{"familyName":"ヨシモト","familyNameLang":"ja-Kana"},{"familyName":"Yoshimoto","familyNameLang":"en"}],"givenNames":[{"givenName":"勝彦","givenNameLang":"ja"},{"givenName":"カツヒコ","givenNameLang":"ja-Kana"},{"givenName":"Katsuhiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1648","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60308/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60308/profile-ja.html"},{"nameIdentifier":"90201863","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=90201863"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-04-17"}],"displaytype":"detail","filename":"jcem_105_6_dgaa040.pdf","filesize":[{"value":"405 KB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007356/files/jcem_105_6_dgaa040.pdf"},"version_id":"51c87c41-c0ee-4c0f-9357-d6c98d6967d0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"pituitary neuroendocrine tumor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pituitary adenoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"familial isolated pituitary adenoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"somatotropinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gigantism","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"aryl hydrocarbon receptor-interacting protein","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Significant Benefits of AIP Testing and Clinical Screening in Familial Isolated and Young-onset Pituitary Tumors","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Significant Benefits of AIP Testing and Clinical Screening in Familial Isolated and Young-onset Pituitary Tumors","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-04-17"},"publish_date":"2020-04-17","publish_status":"0","recid":"2007356","relation_version_is_last":true,"title":["Significant Benefits of AIP Testing and Clinical Screening in Familial Isolated and Young-onset Pituitary Tumors"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T01:09:48.223060+00:00"}