{"created":"2024-10-30T09:21:02.286927+00:00","id":2007407,"links":{},"metadata":{"_buckets":{"deposit":"98a86d34-0de5-4322-9a18-9cee54f07b39"},"_deposit":{"created_by":7,"id":"2007407","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007407"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007407","sets":["1713853213384:1713853295607"]},"author_link":["1556","1521"],"control_number":"2007407","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Notch and Tumor Immunity","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-01-30","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"101","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"Frontiers in Immunology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Cancer immunosurveillance is critical for the elimination of neoplastic cells. In addition, recent advances in immunological checkpoint blockade drugs have revealed the importance of the immune system in cancer treatment. As a component of the immune system, CD8+ T cells have important roles in suppressing tumors. CD8+ T cells can kill tumor cells with cytotoxic molecules, such as granzymes and perforin. IFNγ, which is produced by CD8+ T cells, can increase the expression of MHC class I antigens by tumor cells, thereby rendering them better targets for CD8+ T cells. IFNγ also has crucial functions in enhancing the antitumor abilities of other immune cells. Therefore, it has been hypothesized that antitumor immunity could be improved by modulating the activity of CD8+ T cells. The Notch pathway regulates CD8+ T cells in multiple ways. It directly upregulates mRNA expression of granzyme B and perforin, enhances differentiation toward short-lived effector cells, and maintains memory T cells. Intriguingly, CD8+ T cell-specific Notch2 deletion impairs antitumor immunity, whereas the stimulation of the Notch pathway can increase tumor suppression. In this review, we will summarize the roles of the Notch pathway in CD8+ T cells and discuss issues and implications for its use in antitumor immunity.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Frontiers Media S.A.","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"Copyright © 2018 Tsukumo and Yasutomo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"16643224","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3389/fimmu.2018.00101"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3389/fimmu.2018.00101","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"337602"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"九十九, 伸一","creatorNameLang":"ja"},{"creatorName":"ツクモ, シンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsukumo, Shin-ichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"九十九","familyNameLang":"ja"},{"familyName":"ツクモ","familyNameLang":"ja-Kana"},{"familyName":"Tsukumo","familyNameLang":"en"}],"givenNames":[{"givenName":"伸一","givenNameLang":"ja"},{"givenName":"シンイチ","givenNameLang":"ja-Kana"},{"givenName":"Shin-ichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1556","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60092/profile-ja.html","nameIdentifierScheme":"徳島大学 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Koji","creatorNameLang":"en"}],"familyNames":[{"familyName":"安友","familyNameLang":"ja"},{"familyName":"ヤストモ","familyNameLang":"ja-Kana"},{"familyName":"Yasutomo","familyNameLang":"en"}],"givenNames":[{"givenName":"康二","givenNameLang":"ja"},{"givenName":"コウジ","givenNameLang":"ja-Kana"},{"givenName":"Koji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1521","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60033/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60033/profile-ja.html"},{"nameIdentifier":"30333511","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=30333511"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-11-19"}],"displaytype":"detail","filename":"fimmu_9_101.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007407/files/fimmu_9_101.pdf"},"version_id":"1b3861af-323d-4005-9c65-7ce1e8ac3eaa"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Notch","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"T cells differentiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tumor immunity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CD8+ T cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"granzyme B","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Regulation of CD8+ T Cells and Antitumor Immunity by Notch Signaling","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Regulation of CD8+ T Cells and Antitumor Immunity by Notch Signaling","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-11-19"},"publish_date":"2020-11-19","publish_status":"0","recid":"2007407","relation_version_is_last":true,"title":["Regulation of CD8+ T Cells and Antitumor Immunity by Notch Signaling"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T00:30:09.776696+00:00"}