{"created":"2024-10-30T09:24:22.379774+00:00","id":2007444,"links":{},"metadata":{"_buckets":{"deposit":"6132d350-4b35-409d-beec-f1775ff770b0"},"_deposit":{"created_by":7,"id":"2007444","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007444"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007444","sets":["1713853213384:1713853295607"]},"author_link":["309","197"],"control_number":"2007444","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-18","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"87","bibliographicVolumeNumber":"15","bibliographic_titles":[{"bibliographic_title":"Cardiovascular Diabetology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Xanthine oxidase inhibitors are anti-hyperuricemic drugs that decrease serum uric acid levels by inhibiting its synthesis. Xanthine oxidase is also recognized as a pivotal enzyme in the production of oxidative stress. Excess oxidative stress induces endothelial dysfunction and inflammatory reactions in vascular systems, leading to atherosclerosis. Many experimental studies have suggested that xanthine oxidase inhibitors have anti-atherosclerotic effects by decreasing in vitro and in vivo oxidative stress. However, there is only limited evidence on the clinical implications of xanthine oxidase inhibitors on atherosclerotic cardiovascular disease in patients with hyperuricemia. We designed the PRIZE study to evaluate the effects of febuxostat on a surrogate marker of cardiovascular disease risk, ultrasonography-based intima-media thickness of the carotid artery in patients with hyperuricemia.\nMethods: The study is a multicenter, prospective, randomized, open-label and blinded-endpoint evaluation (PROBE) design. A total of 500 patients with asymptomatic hyperuricemia (uric acid >7.0 mg/dL) and carotid intima-media thickness ≥1.1 mm will be randomized centrally to receive either febuxostat (10–60 mg/day) or non-pharmacological treatment. Randomization is carried out using the dynamic allocation method stratified according to age (<65, ≥65 year), gender, presence or absence of diabetes mellitus, serum uric acid (<8.0, ≥8.0 mg/dL), and carotid intima-media thickness (<1.3, ≥1.3 mm). In addition to administering the study drug, we will also direct lifestyle modification in all participants, including advice on control of body weight, sleep, exercise and healthy diet. Carotid intima-media thickness will be evaluated using ultrasonography performed by skilled technicians at a central laboratory. Follow-up will be continued for 24 months. The primary endpoint is percentage change in mean intima-media thickness of the common carotid artery 24 months after baseline, measured by carotid ultrasound imaging.\nConclusions: PRIZE will be the first study to provide important data on the effects of febuxostat on atherosclerosis in patients with asymptomatic hyperuricemia.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"},{"subitem_publisher":"BioMed Central","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2016 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14752840","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1186/s12933-016-0409-2"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1186/s12933-016-0409-2","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"313985"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"オヤマ, ジュンイチ","creatorNameLang":"ja"},{"creatorName":"オヤマ, ジュンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Oyama, Jun‑ichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タナカ, アツシ","creatorNameLang":"ja"},{"creatorName":"タナカ, アツシ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanaka, Atsushi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"サトウ, ヤスノリ","creatorNameLang":"ja"},{"creatorName":"サトウ, ヤスノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Sato, Yasunori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"トミヤマ, ヒロフミ","creatorNameLang":"ja"},{"creatorName":"トミヤマ, ヒロフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Tomiyama, Hirofumi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"佐田, 政隆","creatorNameLang":"ja"},{"creatorName":"サタ, マサタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Sata, Masataka","creatorNameLang":"en"}],"familyNames":[{"familyName":"佐田","familyNameLang":"ja"},{"familyName":"サタ","familyNameLang":"ja-Kana"},{"familyName":"Sata","familyNameLang":"en"}],"givenNames":[{"givenName":"政隆","givenNameLang":"ja"},{"givenName":"マサタカ","givenNameLang":"ja-Kana"},{"givenName":"Masataka","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"309","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"173932/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/173932/profile-ja.html"},{"nameIdentifier":"80345214","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80345214"}]},{"creatorNames":[{"creatorName":"イシヅ, トモコ","creatorNameLang":"ja"},{"creatorName":"イシヅ, トモコ","creatorNameLang":"ja-Kana"},{"creatorName":"Ishizu, Tomoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タグチ, イサオ","creatorNameLang":"ja"},{"creatorName":"タグチ, イサオ","creatorNameLang":"ja-Kana"},{"creatorName":"Taguchi, Isao","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"クロヤナギ, タカノリ","creatorNameLang":"ja"},{"creatorName":"クロヤナギ, タカノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Kuroyanagi, Takanori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"テラガワ, ヒロキ","creatorNameLang":"ja"},{"creatorName":"テラガワ, ヒロキ","creatorNameLang":"ja-Kana"},{"creatorName":"Teragawa, Hiroki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イシザカ, ノブカズ","creatorNameLang":"ja"},{"creatorName":"イシザカ, ノブカズ","creatorNameLang":"ja-Kana"},{"creatorName":"Ishizaka, Nobukazu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カンザキ, ユミコ","creatorNameLang":"ja"},{"creatorName":"カンザキ, ユミコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kanzaki, Yumiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オオイシ, ミツル","creatorNameLang":"ja"},{"creatorName":"オオイシ, ミツル","creatorNameLang":"ja-Kana"},{"creatorName":"Ohishi, Mitsuru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"エグチ, カズオ","creatorNameLang":"ja"},{"creatorName":"エグチ, カズオ","creatorNameLang":"ja-Kana"},{"creatorName":"Eguchi, Kazuo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヒガシ, ユキヒト","creatorNameLang":"ja"},{"creatorName":"ヒガシ, ユキヒト","creatorNameLang":"ja-Kana"},{"creatorName":"Higashi, Yukihito","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"山田, 博胤","creatorNameLang":"ja"},{"creatorName":"ヤマダ, ヒロツグ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamada, Hirotsugu","creatorNameLang":"en"}],"familyNames":[{"familyName":"山田","familyNameLang":"ja"},{"familyName":"ヤマダ","familyNameLang":"ja-Kana"},{"familyName":"Yamada","familyNameLang":"en"}],"givenNames":[{"givenName":"博胤","givenNameLang":"ja"},{"givenName":"ヒロツグ","givenNameLang":"ja-Kana"},{"givenName":"Hirotsugu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"197","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"123698/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/123698/profile-ja.html"},{"nameIdentifier":"40380084","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40380084"}]},{"creatorNames":[{"creatorName":"マエムラ, コウジ","creatorNameLang":"ja"},{"creatorName":"マエムラ, コウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Maemura, Koji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"アコ, ジュンヤ","creatorNameLang":"ja"},{"creatorName":"アコ, ジュンヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Ako, Junya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"バンドウ, ヤスコ","creatorNameLang":"ja"},{"creatorName":"バンドウ, ヤスコ","creatorNameLang":"ja-Kana"},{"creatorName":"Bando, Yasuko K.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ウエダ, シンイチロウ","creatorNameLang":"ja"},{"creatorName":"ウエダ, シンイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Ueda, Shinichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イノウエ, テルオ","creatorNameLang":"ja"},{"creatorName":"イノウエ, テルオ","creatorNameLang":"ja-Kana"},{"creatorName":"Inoue, Teruo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ムロハラ, トヨアキ","creatorNameLang":"ja"},{"creatorName":"ムロハラ, トヨアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Murohara, Toyoaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ノデ, コウイチ","creatorNameLang":"ja"},{"creatorName":"ノデ, コウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Node, Koichi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-11-26"}],"displaytype":"detail","filename":"cardiab_15_87.pdf","filesize":[{"value":"921 KB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007444/files/cardiab_15_87.pdf"},"version_id":"26a806b2-2b4b-4bd1-8fb4-4d8d751f027d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Carotid artery","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Febuxostat","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hyperuricemia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Intima-media thickness (IMT)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Randomized controlled trial","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Xanthine oxidase inhibitor","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Rationale and design of a multicenter randomized study for evaluating vascular function under uric acid control using the xanthine oxidase inhibitor, febuxostat : the PRIZE study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Rationale and design of a multicenter randomized study for evaluating vascular function under uric acid control using the xanthine oxidase inhibitor, febuxostat : the PRIZE study","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-11-26"},"publish_date":"2020-11-26","publish_status":"0","recid":"2007444","relation_version_is_last":true,"title":["Rationale and design of a multicenter randomized study for evaluating vascular function under uric acid control using the xanthine oxidase inhibitor, febuxostat : the PRIZE study"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T06:58:57.165225+00:00"}