{"created":"2024-10-30T09:24:47.181508+00:00","id":2007448,"links":{},"metadata":{"_buckets":{"deposit":"fe476bf6-50a5-4777-bed9-abcd69891f60"},"_deposit":{"created_by":7,"id":"2007448","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007448"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007448","sets":["1713853213384:1713853295607"]},"author_link":["501","309"],"control_number":"2007448","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-07-06","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"86","bibliographicVolumeNumber":"16","bibliographic_titles":[{"bibliographic_title":"Cardiovascular Diabetology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Little is known about clinical associations between glucose fluctuations including hypoglycemia, heart rate variability (HRV), and the activity of the sympathetic nervous system (SNS) in patients with acute phase of acute coronary syndrome (ACS). This pilot study aimed to evaluate the short-term effects of glucose fluctuations on HRV and SNS activity in type 2 diabetes mellitus (T2DM) patients with recent ACS. We also examined the effect of suppressing glucose fluctuations with miglitol on these variables.\nMethods: This prospective, randomized, open-label, blinded-endpoint, multicenter, parallel-group comparative study included 39 T2DM patients with recent ACS, who were randomly assigned to either a miglitol group (n = 19) or a control group (n = 20). After initial 24-h Holter electrocardiogram (ECG) (Day 1), miglitol was commenced and another 24-h Holter ECG (Day 2) was recorded. In addition, continuous glucose monitoring (CGM) was performed throughout the Holter ECG.\nResults: Although frequent episodes of subclinical hypoglycemia (≤4.44 mmo/L) during CGM were observed on Day 1 in the both groups (35% of patients in the control group and 31% in the miglitol group), glucose fluctuations were decreased and the minimum glucose level was increased with substantial reduction in the episodes of subclinical hypoglycemia to 7.7% in the miglitol group on Day 2. Holter ECG showed that the mean and maximum heart rate and mean LF/HF were increased on Day 2 in the control group, and these increases were attenuated by miglitol. When divided 24-h time periods into day-time (0700–1800 h), night-time (1800–0000 h), and bed-time (0000–0700 h), we found increased SNS activity during day-time, increased maximum heart rate during night-time, and glucose fluctuations during bed-time, which were attenuated by miglitol treatment.\nConclusions: In T2DM patients with recent ACS, glucose fluctuations with subclinical hypoglycemia were associated with alterations of HRV and SNS activity, which were mitigated by miglitol, suggesting that these pathological relationships may be a residual therapeutic target in such patients.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"},{"subitem_publisher":"BioMed Central","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14752840","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1186/s12933-017-0571-1"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1186/s12933-017-0571-1","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"325813"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"島袋, 充生","creatorNameLang":"ja"},{"creatorName":"シマブクロ, ミチオ","creatorNameLang":"ja-Kana"},{"creatorName":"Shimabukuro, Michio","creatorNameLang":"en"}],"familyNames":[{"familyName":"島袋","familyNameLang":"ja"},{"familyName":"シマブクロ","familyNameLang":"ja-Kana"},{"familyName":"Shimabukuro","familyNameLang":"en"}],"givenNames":[{"givenName":"充生","givenNameLang":"ja"},{"givenName":"ミチオ","givenNameLang":"ja-Kana"},{"givenName":"Michio","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"501","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60271144","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60271144"}]},{"creatorNames":[{"creatorName":"タナカ, アツシ","creatorNameLang":"ja"},{"creatorName":"タナカ, アツシ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanaka, Atsushi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"佐田, 政隆","creatorNameLang":"ja"},{"creatorName":"サタ, マサタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Sata, Masataka","creatorNameLang":"en"}],"familyNames":[{"familyName":"佐田","familyNameLang":"ja"},{"familyName":"サタ","familyNameLang":"ja-Kana"},{"familyName":"Sata","familyNameLang":"en"}],"givenNames":[{"givenName":"政隆","givenNameLang":"ja"},{"givenName":"マサタカ","givenNameLang":"ja-Kana"},{"givenName":"Masataka","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"309","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"173932/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/173932/profile-ja.html"},{"nameIdentifier":"80345214","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80345214"}]},{"creatorNames":[{"creatorName":"ダイ, カズオキ","creatorNameLang":"ja"},{"creatorName":"ダイ, カズオキ","creatorNameLang":"ja-Kana"},{"creatorName":"Dai, Kazuoki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"シバタ, ヨシサト","creatorNameLang":"ja"},{"creatorName":"シバタ, ヨシサト","creatorNameLang":"ja-Kana"},{"creatorName":"Shibata, Yoshisato","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イノウエ, ヨウヘイ","creatorNameLang":"ja"},{"creatorName":"イノウエ, ヨウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"Inoue, Yohei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イケナガ, ヒロキ","creatorNameLang":"ja"},{"creatorName":"イケナガ, ヒロキ","creatorNameLang":"ja-Kana"},{"creatorName":"Ikenaga, Hiroki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"キシモト, シンジ","creatorNameLang":"ja"},{"creatorName":"キシモト, シンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Kishimoto, Shinji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オガサワラ, コズエ","creatorNameLang":"ja"},{"creatorName":"オガサワラ, コズエ","creatorNameLang":"ja-Kana"},{"creatorName":"Ogasawara, Kozue","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タカシマ, アキラ","creatorNameLang":"ja"},{"creatorName":"タカシマ, アキラ","creatorNameLang":"ja-Kana"},{"creatorName":"Takashima, Akira","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"仁木, 敏之","creatorNameLang":"ja"},{"creatorName":"ニキ, トシユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Niki, Toshiyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"アラサキ, オサム","creatorNameLang":"ja"},{"creatorName":"アラサキ, オサム","creatorNameLang":"ja-Kana"},{"creatorName":"Arasaki, Osamu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オオシロ, コウイチ","creatorNameLang":"ja"},{"creatorName":"オオシロ, コウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Oshiro, Koichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"モリ, ユタカ","creatorNameLang":"ja"},{"creatorName":"モリ, ユタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Mori, Yutaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イシハラ, マサハル","creatorNameLang":"ja"},{"creatorName":"イシハラ, マサハル","creatorNameLang":"ja-Kana"},{"creatorName":"Ishihara, Masaharu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ノデ, コウイチ","creatorNameLang":"ja"},{"creatorName":"ノデ, コウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Node, Koichi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-11-26"}],"displaytype":"detail","filename":"cardiab_16_86.pdf","filesize":[{"value":"2.26 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007448/files/cardiab_16_86.pdf"},"version_id":"f15854d8-3ad4-48cd-bf02-2d8b7a7edb1f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Acute coronary syndrome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Glucose fluctuation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Heart rate variability","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hypoglycemia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Miglitol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Sympathetic nervous system activity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Type 2 diabetes","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"α‑Glucosidase inhibitor miglitol attenuates glucose fluctuation, heart rate variability and sympathetic activity in patients with type 2 diabetes and acute coronary syndrome : a multicenter randomized controlled (MACS) study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"α‑Glucosidase inhibitor miglitol attenuates glucose fluctuation, heart rate variability and sympathetic activity in patients with type 2 diabetes and acute coronary syndrome : a multicenter randomized controlled (MACS) study","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-11-26"},"publish_date":"2020-11-26","publish_status":"0","recid":"2007448","relation_version_is_last":true,"title":["α‑Glucosidase inhibitor miglitol attenuates glucose fluctuation, heart rate variability and sympathetic activity in patients with type 2 diabetes and acute coronary syndrome : a multicenter randomized controlled (MACS) study"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T13:34:02.729946+00:00"}