{"created":"2024-10-30T09:24:53.833981+00:00","id":2007449,"links":{},"metadata":{"_buckets":{"deposit":"5e929733-9028-4f10-9815-310ca3ed042b"},"_deposit":{"created_by":7,"id":"2007449","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007449"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007449","sets":["1713853213384:1713853295607"]},"author_link":["309","197"],"control_number":"2007449","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-09-13","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"134","bibliographicVolumeNumber":"15","bibliographic_titles":[{"bibliographic_title":"Cardiovascular Diabetology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: As a sub-analysis of the PROLOGUE study, we evaluated the long-term effect of sitagliptin, a dipeptidyl peptidase 4 inhibitor, on endothelial function in the conduit brachial artery in patients with type 2 diabetes.\nMethods: In the PROLOGUE study, patients were randomly assigned to either add-on sitagliptin treatment (sitagliptin group) or continued conventional antihyperglycemic treatment (conventional group). Among the 463 participants in the PROLOGUE study, FMD was measured in 17 patients in the sitagliptin group and 18 patients in the conventional group at the beginning and after 12 and 24 months of treatment.\nResults: HbA1c levels were significantly decreased after 12 and 24 months of treatment compared to baseline values in both groups (7.0 ± 0.4 vs. 6.6 ± 0.3 and 6.6 ± 0.4 % in the sitagliptin group; 7.0 ± 0.6 vs. 6.6 ± 0.7 and 6.6 ± 0.7 % in the conventional group; P < 0.05, respectively). There was no significant difference between FMD values at baseline and after 12 and 24 months in the sitagliptin group (4.3 ± 2.6 vs. 4.4 ± 2.1 and 4.4 ± 2.3 %, P = 1.0, respectively). Although FMD had a tendency to increase from 4.3 ± 2.4 % at baseline to 5.2 ± 1.9 % after 12 months and 5.1 ± 2.2 % after 24 months in the conventional group, there was no significant difference between FMD values at baseline and after 12 and 24 months (P = 0.36 and 0.33, respectively).\nConclusions: Add-on sitagliptin to conventional antihyperglycemic drugs in patients with type 2 diabetes did not alter endothelial function in the conduit brachial artery measured by FMD during a 2-year study period. Sitagliptin may be used without concern for an adverse effect on endothelial function in patients with type 2 diabetes.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"},{"subitem_publisher":"BioMed Central","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2016 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14752840","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1186/s12933-016-0438-x"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1186/s12933-016-0438-x","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"344831"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"マルハシ, タツヤ","creatorNameLang":"ja"},{"creatorName":"マルハシ, タツヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Maruhashi, Tatsuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヒガシ, ユキヒト","creatorNameLang":"ja"},{"creatorName":"ヒガシ, ユキヒト","creatorNameLang":"ja-Kana"},{"creatorName":"Higashi, Yukihito","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"キハラ, ヤスキ","creatorNameLang":"ja"},{"creatorName":"キハラ, ヤスキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kihara, Yasuki","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"山田, 博胤","creatorNameLang":"ja"},{"creatorName":"ヤマダ, ヒロツグ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamada, Hirotsugu","creatorNameLang":"en"}],"familyNames":[{"familyName":"山田","familyNameLang":"ja"},{"familyName":"ヤマダ","familyNameLang":"ja-Kana"},{"familyName":"Yamada","familyNameLang":"en"}],"givenNames":[{"givenName":"博胤","givenNameLang":"ja"},{"givenName":"ヒロツグ","givenNameLang":"ja-Kana"},{"givenName":"Hirotsugu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"197","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"123698/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/123698/profile-ja.html"},{"nameIdentifier":"40380084","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40380084"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"佐田, 政隆","creatorNameLang":"ja"},{"creatorName":"サタ, マサタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Sata, Masataka","creatorNameLang":"en"}],"familyNames":[{"familyName":"佐田","familyNameLang":"ja"},{"familyName":"サタ","familyNameLang":"ja-Kana"},{"familyName":"Sata","familyNameLang":"en"}],"givenNames":[{"givenName":"政隆","givenNameLang":"ja"},{"givenName":"マサタカ","givenNameLang":"ja-Kana"},{"givenName":"Masataka","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"309","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"173932/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/173932/profile-ja.html"},{"nameIdentifier":"80345214","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80345214"}]},{"creatorNames":[{"creatorName":"ウエダ, シンイチロウ","creatorNameLang":"ja"},{"creatorName":"ウエダ, シンイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Ueda, Shinichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オダワラ, マサト","creatorNameLang":"ja"},{"creatorName":"オダワラ, マサト","creatorNameLang":"ja-Kana"},{"creatorName":"Odawara, Masato","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"テラウチ, ヤスオ","creatorNameLang":"ja"},{"creatorName":"テラウチ, ヤスオ","creatorNameLang":"ja-Kana"},{"creatorName":"Terauchi, Yasuo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ダイ, カズオキ","creatorNameLang":"ja"},{"creatorName":"ダイ, カズオキ","creatorNameLang":"ja-Kana"},{"creatorName":"Dai, Kazuoki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オオノ, ジュン","creatorNameLang":"ja"},{"creatorName":"オオノ, ジュン","creatorNameLang":"ja-Kana"},{"creatorName":"Ohno, Jun","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イイダ, マサト","creatorNameLang":"ja"},{"creatorName":"イイダ, マサト","creatorNameLang":"ja-Kana"},{"creatorName":"Iida, Masato","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"サノ, ヒロアキ","creatorNameLang":"ja"},{"creatorName":"サノ, ヒロアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Sano, Hiroaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"トミヤマ, ヒロフミ","creatorNameLang":"ja"},{"creatorName":"トミヤマ, ヒロフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Tomiyama, Hirofumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イノウエ, テルオ","creatorNameLang":"ja"},{"creatorName":"イノウエ, テルオ","creatorNameLang":"ja-Kana"},{"creatorName":"Inoue, Teruo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タナカ, アツシ","creatorNameLang":"ja"},{"creatorName":"タナカ, アツシ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanaka, Atsushi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ムロハラ, トヨアキ","creatorNameLang":"ja"},{"creatorName":"ムロハラ, トヨアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Murohara, Toyoaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ノデ, コウイチ","creatorNameLang":"ja"},{"creatorName":"ノデ, コウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Node, Koichi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-11-26"}],"displaytype":"detail","filename":"cardiab_15_134.pdf","filesize":[{"value":"853 KB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007449/files/cardiab_15_134.pdf"},"version_id":"6c0603a0-91ce-4c0c-ba73-9a15c3b5dc94"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Dipeptidyl peptidase 4 inhibitor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Flow-mediated vasodilation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Type 2 diabetes","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Long‑term effect of sitagliptin on endothelial function in type 2 diabetes : a sub‑analysis of the PROLOGUE study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Long‑term effect of sitagliptin on endothelial function in type 2 diabetes : a sub‑analysis of the PROLOGUE study","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-11-26"},"publish_date":"2020-11-26","publish_status":"0","recid":"2007449","relation_version_is_last":true,"title":["Long‑term effect of sitagliptin on endothelial function in type 2 diabetes : a sub‑analysis of the PROLOGUE study"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T06:58:57.873050+00:00"}