{"created":"2024-10-30T09:25:06.022092+00:00","id":2007451,"links":{},"metadata":{"_buckets":{"deposit":"866c3fca-eac5-433c-9e93-e1dfd1a4a40c"},"_deposit":{"created_by":7,"id":"2007451","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007451"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007451","sets":["1713853213384:1713853295607"]},"author_link":["851"],"control_number":"2007451","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-07","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"133","bibliographicVolumeNumber":"18","bibliographic_titles":[{"bibliographic_title":"Arthritis Research & Therapy","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: The aim of this study was to assess the effects of soluble sialic acid-binding immunoglobulin-type lectin (sSiglec)-9 on joint inflammation and destruction in a murine collagen-induced arthritis (CIA) model and in monolayer cultures of murine macrophages (RAW264.7 cells and peritoneal macrophages) and fibroblast-like synoviocytes (FLS) derived from patients with rheumatoid arthritis.\nMethods: DBA/1J mice were immunized with type II collagen. Effects of sSiglec-9 were evaluated using a physiologic arthritis score, histological analysis, serum tumor necrosis factor (TNF)-α concentration, and the proportion of forkhead box P3 (Foxp3)-positive regulatory T (Treg) cells. In vivo biofluorescence imaging was used to assess the distribution of sSiglec-9. Levels of M1 (TNF-α, interleukin [IL]-6, and inducible nitric oxide synthase) and M2 (CD206, Arginase-1, and IL-10) macrophage markers and phosphorylation of intracellular signaling molecules were examined in macrophages, and levels of matrix metalloproteinase (MMP)-1, MMP-3, and MMP-13 were examined in FLS.\nResults: sSiglec-9 significantly suppressed the clinical and histological incidence and severity of arthritis. The proportion of Foxp3-positive Treg cells significantly improved and serum TNF-α concentration decreased in vivo. Although sSiglec-9 reduced the expression of M1 markers in macrophages, it did not affect the expression of M2 markers and MMPs in FLS. Nuclear factor (NF)-kB p65 phosphorylation was attenuated by sSiglec-9, and chemical blockade of the NF-kB pathway reduced M1 marker expression in RAW264.7 cells.\nConclusions: In this study, we have demonstrated the therapeutic effects of sSiglec-9 in a murine CIA model. The mechanism underlying these effects involves the suppression of M1 proinflammatory macrophages by inhibiting the NF-kB pathway. sSiglec-9 may provide a novel therapeutic option for patients with rheumatoid arthritis refractory to currently available drugs.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"},{"subitem_publisher":"BioMed Central","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14786362","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1186/s13075-016-1035-9"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1186/s13075-016-1035-9","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"321510"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"マツモト, タクヤ","creatorNameLang":"ja"},{"creatorName":"マツモト, タクヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsumoto, Takuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タカハシ, ノブノリ","creatorNameLang":"ja"},{"creatorName":"タカハシ, ノブノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Takahashi, Nobunori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"コジマ, トシヒサ","creatorNameLang":"ja"},{"creatorName":"コジマ, トシヒサ","creatorNameLang":"ja-Kana"},{"creatorName":"Kojima, Toshihisa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヨシオカ, ユタカ","creatorNameLang":"ja"},{"creatorName":"ヨシオカ, ユタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshioka, Yutaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イシカワ, ジュン","creatorNameLang":"ja"},{"creatorName":"イシカワ, ジュン","creatorNameLang":"ja-Kana"},{"creatorName":"Ishikawa, Jun","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"フルカワ, コウイチ","creatorNameLang":"ja"},{"creatorName":"フルカワ, コウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Furukawa, Koichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オノ, ケンジ","creatorNameLang":"ja"},{"creatorName":"オノ, ケンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Ono, Kenji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"サワダ, マコト","creatorNameLang":"ja"},{"creatorName":"サワダ, マコト","creatorNameLang":"ja-Kana"},{"creatorName":"Sawada, Makoto","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イシグロ, ナオキ","creatorNameLang":"ja"},{"creatorName":"イシグロ, ナオキ","creatorNameLang":"ja-Kana"},{"creatorName":"Ishiguro, Naoki","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"山本, 朗仁","creatorNameLang":"ja"},{"creatorName":"ヤマモト, アキヒト","creatorNameLang":"ja-Kana"},{"creatorName":"Yamamoto, Akihito","creatorNameLang":"en"}],"familyNames":[{"familyName":"山本","familyNameLang":"ja"},{"familyName":"ヤマモト","familyNameLang":"ja-Kana"},{"familyName":"Yamamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"朗仁","givenNameLang":"ja"},{"givenName":"アキヒト","givenNameLang":"ja-Kana"},{"givenName":"Akihito","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"851","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"321104/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/321104/profile-ja.html"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-11-26"}],"displaytype":"detail","filename":"artreth_18_133.pdf","filesize":[{"value":"2.03 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007451/files/artreth_18_133.pdf"},"version_id":"94ad4bfc-fd84-4e4d-984a-f232e1d98709"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Rheumatoid arthritis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Collagen-induced arthritis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Siglec-9","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-11-26"},"publish_date":"2020-11-26","publish_status":"0","recid":"2007451","relation_version_is_last":true,"title":["Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T12:21:49.132327+00:00"}