{"created":"2024-10-30T09:26:13.579877+00:00","id":2007464,"links":{},"metadata":{"_buckets":{"deposit":"841b040e-f74a-46c5-bf54-9c4ac53e5c58"},"_deposit":{"created_by":7,"id":"2007464","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007464"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007464","sets":["1713853213384:1713853296295:1716267876683:1716268552315"]},"author_link":["496","443","1559","176","269"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"乳癌捺印細胞診検体のHER2およびKi67免疫染色は組織診断に代替可能である","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-03-26","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"582","bibliographicPageStart":"577","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"Breast Cancer","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Re-evaluation of the subtype of recurrent breast cancer is necessary for deciding the treatment approach, but it is often not performed due to the difficulty of obtaining tissue specimens from a recurrent lesion, etc. However, when a recurrent lesion is close to the body surface, fine-needle aspiration cells (FNA cells) can be easily obtained, and immunocytochemical (ICC) analysis of hormone receptors expression in FNA cells is said to be highly reliable. However, there is no consensus regarding ICC analysis of human epidermal growth factor receptor type2 (HER2) expression and the Ki67 index using FNA cells.\nMethods: Touch-smear cells (TSC) were prepared from resected specimens from 36 patients with primary invasive ductal carcinoma of the breast. The TSC were fixed in 95% ethanol and subjected to ICC analysis for HER2 using HercepTestTM (Dako) and Ki67 using MIB-1TM (Dako). HER2 expression and the Ki67 index for the TSC were compared with the results of immunohistochemical analysis of histological section (HS). Statistical analyses used the kappa test and Pearson’s correlation coefficients.\nResults: HER2 and Ki67 were analyzed in TSC from 36 and 28 patients, respectively. The HER2 expression scores in the TSC and HS groups showed good agreement (kappa value=0.640), and significant correlation (correlation coefficient=0.860, p<0.001). The Ki67 indexes in the TSC and HS groups also showed significant correlation (correlation coefficient=0.861, p<0.001).\nConclusions: The reliability of ICC analysis of HER2 expression and the Ki67 index using TSC were recognized.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"},{"subitem_publisher":"The Japanese Breast Cancer Society","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13406868","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"18804233","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA1103354X","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第2112号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-03-18"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Masami Morimotoの学位論文として提出され，学位審査・授与の対象となっている。\nThis version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s12282-015-0605-z"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"乙医第1760号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1007/s12282-015-0605-z"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s12282-015-0605-z","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"300310"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"森本, 雅美","creatorNameLang":"ja"},{"creatorName":"モリモト, マサミ","creatorNameLang":"ja-Kana"},{"creatorName":"Morimoto, 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cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HER2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ki67","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Immunocytochemical analysis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Touch-smear cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Immunocytochemical results for HER2 and Ki67 in breast cancer touch-smear cell specimens are reliable","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Immunocytochemical results for HER2 and Ki67 in breast cancer touch-smear cell specimens are reliable","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268552315"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-03-27"},"publish_date":"2020-03-27","publish_status":"0","recid":"2007464","relation_version_is_last":true,"title":["Immunocytochemical results for HER2 and Ki67 in breast cancer touch-smear cell specimens are reliable"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-06T05:55:50.334725+00:00"}