{"created":"2024-10-30T09:26:25.159431+00:00","id":2007466,"links":{},"metadata":{"_buckets":{"deposit":"784efa73-2790-4265-9928-f56102da59b5"},"_deposit":{"created_by":7,"id":"2007466","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007466"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007466","sets":["1713853213384:1713853295607"]},"author_link":["354","1535"],"control_number":"2007466","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-08-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"37","bibliographicVolumeNumber":"2","bibliographic_titles":[{"bibliographic_title":"Renal Replacement Therapy","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Peripheral arterial disease (PAD) is a common complication in dialysis patients. Early diagnosis and treatment are recommended. Low-density lipoprotein apheresis (LDL-A) is a potential therapy to improve PAD. However, the mechanism has yet to be fully clarified due to lack of established quantitative methods to assess the therapeutic effects of LDL-A treatment. Improvement of skin perfusion pressure (SPP) or ankle brachial index (ABI) is a representative therapy goal, but clinical symptoms were not always consistent with the values of SPP/ABI. Vascular quality of life questionnaire (VascuQOL) was proposed as a disease-specific QOL score, getting validated recently. The possibility of VascuQOL to reflect the severity of PAD in dialysis patients and evaluate the therapeutic effects of LDL-A has yet to be elucidated.\nMethods: This is an observational study. LDL-A treatment was performed in 32 dialysis patients with PAD. They were divided to critical limb ischemia (CLI) group (17 subjects) and non-CLI group (15 subjects) according to their clinical manifestations. We examined the relationship of PAD severity with SPP, ABI, VascuQOL, and lipid profile such as apoB/apoA-I ratio, malondialdehyde-modified LDL, and remnant-like particles cholesterol. Furthermore, we evaluated these parameters successively to find out a suitable therapeutic marker just after the first LDL-A, at tenth LDL-A, and 1 month after completion of LDL-A treatment.\nResults: All of the lipid markers were higher in CLI patients, but not significantly different from those in the non-CLI group. They decreased significantly just after LDL-A, although no changes were observed 1 month after completion of LDL-A treatment. ABI was significantly different between the CLI and non-CLI groups, but did not improve by LDL-A treatment. By contrast, SPP was ameliorated significantly and the peak was at tenth LDL-A. Among VascuQOL domains, “Symptom” and “Emotional” domains were significantly different between the CLI and non-CLI groups. The average score of VascuQOL increased successively until 1 month after completion of LDL-A treatment.\nConclusions: Several domains of VascuQOL can reflect the severity of PAD in dialysis patients. VascuQOL was a useful marker to show the prolonged therapeutic effects of LDL-A treatment in dialysis patients with PAD, independent of SPP.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central","subitem_publisher_language":"en"},{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20591381","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1186/s41100-016-0048-9"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1186/s41100-016-0048-9","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"329374"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"長井, 幸二郎","creatorNameLang":"ja"},{"creatorName":"ナガイ, コウジロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Nagai, Kojiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"長井","familyNameLang":"ja"},{"familyName":"ナガイ","familyNameLang":"ja-Kana"},{"familyName":"Nagai","familyNameLang":"en"}],"givenNames":[{"givenName":"幸二郎","givenNameLang":"ja"},{"givenName":"コウジロウ","givenNameLang":"ja-Kana"},{"givenName":"Kojiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"354","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40542048","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40542048"}]},{"creatorNames":[{"creatorName":"ハラダ, メグミ","creatorNameLang":"ja"},{"creatorName":"ハラダ, メグミ","creatorNameLang":"ja-Kana"},{"creatorName":"Harada, Megumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヨコタ, ナルシ","creatorNameLang":"ja"},{"creatorName":"ヨコタ, ナルシ","creatorNameLang":"ja-Kana"},{"creatorName":"Yokota, Narushi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オカダ, ダイゴ","creatorNameLang":"ja"},{"creatorName":"オカダ, ダイゴ","creatorNameLang":"ja-Kana"},{"creatorName":"Okada, Daigo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ミチワキ, ヒロユキ","creatorNameLang":"ja"},{"creatorName":"ミチワキ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Michiwaki, Hiroyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヒロセ, ダイスケ","creatorNameLang":"ja"},{"creatorName":"ヒロセ, ダイスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Hirose, Daisuke","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"土井, 俊夫","creatorNameLang":"ja"},{"creatorName":"ドイ, トシオ","creatorNameLang":"ja-Kana"},{"creatorName":"Doi, Toshio","creatorNameLang":"en"}],"familyNames":[{"familyName":"土井","familyNameLang":"ja"},{"familyName":"ドイ","familyNameLang":"ja-Kana"},{"familyName":"Doi","familyNameLang":"en"}],"givenNames":[{"givenName":"俊夫","givenNameLang":"ja"},{"givenName":"トシオ","givenNameLang":"ja-Kana"},{"givenName":"Toshio","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1535","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60048/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60048/profile-ja.html"},{"nameIdentifier":"60183498","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60183498"}]},{"creatorNames":[{"creatorName":"ミナクチ, ジュン","creatorNameLang":"ja"},{"creatorName":"ミナクチ, ジュン","creatorNameLang":"ja-Kana"},{"creatorName":"Minakuchi, Jun","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ツチダ, ケンジ","creatorNameLang":"ja"},{"creatorName":"ツチダ, ケンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsuchida, Kenji","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-11-30"}],"displaytype":"detail","filename":"rrt_2_37.pdf","filesize":[{"value":"568 KB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007466/files/rrt_2_37.pdf"},"version_id":"4cf8832a-aacd-41e8-85a2-1ca53aaf0fe5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Vascular quality of life questionnaire (VascuQOL)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Peripheral arterial disease (PAD)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Low-density lipoprotein apheresis (LDL-A)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Skin perfusion pressure (SPP)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ankle brachial index (ABI)","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Evaluation of vascular quality of life questionnaire in dialysis patients with peripheral arterial disease treated by low-density lipoprotein apheresis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Evaluation of vascular quality of life questionnaire in dialysis patients with peripheral arterial disease treated by low-density lipoprotein apheresis","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-11-30"},"publish_date":"2020-11-30","publish_status":"0","recid":"2007466","relation_version_is_last":true,"title":["Evaluation of vascular quality of life questionnaire in dialysis patients with peripheral arterial disease treated by low-density lipoprotein apheresis"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T00:57:46.418396+00:00"}