{"created":"2024-10-30T09:27:03.109731+00:00","id":2007473,"links":{},"metadata":{"_buckets":{"deposit":"92d5cadd-0342-4828-bc9e-8329733bb044"},"_deposit":{"created_by":7,"id":"2007473","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007473"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007473","sets":["1713853213384:1713853295607"]},"author_link":["900"],"control_number":"2007473","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-01-19","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Radiation Oncology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Standard chemoradiotherapy (CRT) using cisplatin (CDDP) and 5-fluorouracil (5-FU) is an optional treatment for patients with stage II-III esophageal cancer. However, there are some demerits in this regimen because CDDP administration requires a large transfusion volume and 5-FU must be continuously infused over 24 h. Therefore, hospitalization is unavoidable. We collected retrospectively the data of definitive CRT with nedaplatin and S-1 as carried out in our institution.\nMethods: Patients with early and advanced esophageal cancer and relapsed esophageal cancer after radical surgery were included. Nedaplatin 80 mg/m2 was given on days 1 and 29, and S-1 80 mg/m2 on days 1-14 and 29-42. No prophylactic treatment with granulocyte colony stimulating factor was administered. Patients received two courses of concurrent radiotherapy of more than 50 Gy with or without two additional courses as adjuvant therapy every 4 weeks.\nResults: Between August 2011 and June 2015, 89 patients (age range, 44–86 years; K-PS 90–100, 81 %; squamous cell carcinoma histology, 97 %; definitive/salvage CRT, 75/25 %) were collected. Twenty-one (24 %) patients completed four cycles, and 94 % received two or more cycles. Grade 4 leukopenia, thrombocytopenia, and anemia occurred in 12, 7, and 10 % of the patients, respectively. Five patients developed febrile neutropenia. Grade 3 non-hematological toxicity included infection in 12 %, mucositis/esophagitis in 3 %, kidney in 3 %, and fatigue in 3 %. Sixty-four patients (72 %) received the prescribed full dose and full cycles of chemotherapy. A complete response was achieved in 76 patients (85 %). The 3-year overall survival rate was 54.4 % in definitive CRT and 39.8 % in salvage CRT, respectively. Sixty-two subjects (70 %) received treatment as outpatients.\nConclusions: Nedaplatin and S-1 in combination with radiotherapy is feasible, and toxicity is tolerable. This treatment method has the potential to shorten hospitalization without impairing the efficacy of CRT.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central","subitem_publisher_language":"en"},{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2016 Yamashita et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"1748717X","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1186/s13014-016-0587-9"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1186/s13014-016-0587-9","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"334501"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ヤマシタ, ヒデオミ","creatorNameLang":"ja"},{"creatorName":"ヤマシタ, ヒデオミ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamashita, Hideomi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"芳賀, 昭弘","creatorNameLang":"ja"},{"creatorName":"ハガ, アキヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Haga, Akihiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"芳賀","familyNameLang":"ja"},{"familyName":"ハガ","familyNameLang":"ja-Kana"},{"familyName":"Haga","familyNameLang":"en"}],"givenNames":[{"givenName":"昭弘","givenNameLang":"ja"},{"givenName":"アキヒロ","givenNameLang":"ja-Kana"},{"givenName":"Akihiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"900","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"334008/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/334008/profile-ja.html"}]},{"creatorNames":[{"creatorName":"タケナカ, リョウスケ","creatorNameLang":"ja"},{"creatorName":"タケナカ, リョウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Takenaka, Ryousuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"キリトオシ, トモキ","creatorNameLang":"ja"},{"creatorName":"キリトオシ, トモキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kiritoshi, Tomoki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オオクマ, カエ","creatorNameLang":"ja"},{"creatorName":"オオクマ, カエ","creatorNameLang":"ja-Kana"},{"creatorName":"Okuma, Kae","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オオトモ, クニ","creatorNameLang":"ja"},{"creatorName":"オオトモ, クニ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohtomo, Kuni","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ナカガワ, ケイイチ","creatorNameLang":"ja"},{"creatorName":"ナカガワ, ケイイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakagawa, Keiichi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-12-07"}],"displaytype":"detail","filename":"radonc_11_4.pdf","filesize":[{"value":"734 KB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007473/files/radonc_11_4.pdf"},"version_id":"7813b502-345b-4305-a0c4-6a65d765c1c6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Esophageal cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Definitive chemoradiotherapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Nedaplatin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"S-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Efficacy and feasibility of ambulatory treatment-based monthly nedaplatin plus S-1 in definitive or salvage concurrent chemoradiotherapy for early, advanced, and relapsed esophageal cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Efficacy and feasibility of ambulatory treatment-based monthly nedaplatin plus S-1 in definitive or salvage concurrent chemoradiotherapy for early, advanced, and relapsed esophageal cancer","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-12-07"},"publish_date":"2020-12-07","publish_status":"0","recid":"2007473","relation_version_is_last":true,"title":["Efficacy and feasibility of ambulatory treatment-based monthly nedaplatin plus S-1 in definitive or salvage concurrent chemoradiotherapy for early, advanced, and relapsed esophageal cancer"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T13:15:36.092825+00:00"}