| Item type |
文献 / Documents(1) |
| 公開日 |
2020-04-17 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
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|
関連識別子 |
https://doi.org/10.2152/jmi.67.51 |
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関連名称 |
10.2152/jmi.67.51 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Gene-expression profile reveals the genetic and acquired phenotypes of hyperactive mutant SPORTS rat |
| タイトル別表記 |
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その他のタイトル |
Metabolic remodeling of hyperactive rats |
| 著者 |
堀口, 大吾
ミヤタケ, ユミコ
三好, 圭子
谷村, 綾子
ハギタ, ヒロコ
阪上, 浩
野間, 隆文
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| 抄録 |
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内容記述 |
Spontaneously Running Tokushima Shikoku (SPORTS) rat is a hyperactive rat strain. However, the causative mutation of this phenotype has not yet been identified. To investigate the molecular basis for the unique phenotype of SPORTS rats, we examined gene-expression profiles by microarray analyses. Among adenylate kinase isozymes that maintain the homeostasis of cellular adenine nucleotide composition in the cell, only adenylate kinase 1 is highly up-regulated in both exercised and sedentary SPORTS rats compared with wild-type (WT) rats, 5.5-fold and 3.3-fold, respectively. Further comparative analyses revealed that genes involved in glucose metabolism were up-regulated in skeletal muscle tissue of exercised SPORTS rats compared with sedentary mutants, whereas genes related to extracellular matrix or region were down-regulated compared with WT rats. In brain tissue of sedentary SPORTS rats, genes associated with defense and catecholamine metabolism were highly expressed compared with WT rats. These findings suggest that genetic mutation(s) in SPORTS rat remodels metabolic demands through differentially regulating gene expression regardless of exercise. Therefore, the SPORTS rats are useful animal model not only for further examining the effects of exercise on metabolism but also for deeply studying the molecular basis how mutation affect the psychological motivation with spontaneous voluntary exercise phenotype. |
| キーワード |
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|
主題 |
adenylate kinase |
| キーワード |
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|
主題 |
energy metabolism |
| キーワード |
|
|
主題 |
microarray analysis |
| キーワード |
|
|
主題 |
SPORTS rats |
| キーワード |
|
|
主題 |
voluntary exercise |
| 書誌情報 |
en : The Journal of Medical Investigation
巻 67,
号 1-2,
p. 51-61,
発行日 2020-02
|
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13496867 |
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12022913 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| 出版者 |
|
|
出版者 |
Tokushima University Faculty of Medicine |
| EID |
|
|
識別子 |
364738 |
| 言語 |
|
|
言語 |
eng |
jmi_67_1-2_51.pdf (841 KB)
