{"created":"2024-10-30T09:29:13.649286+00:00","id":2007500,"links":{},"metadata":{"_buckets":{"deposit":"d5a7602b-9795-4afc-8103-89b1b58dcf86"},"_deposit":{"created_by":7,"id":"2007500","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007500"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007500","sets":["1713853213384:1713853296295:1716267877313:1716268556148"]},"author_link":["484","1691","909","1704","566","1653"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"カフェイン酸フェネチルエステル（CAPE）がラット象牙芽細胞様細胞のVEGF発現と産生に与える影響","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-12-21","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5390720","bibliographicVolumeNumber":"2019","bibliographic_titles":[{"bibliographic_title":"BioMed Research International","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Caffeic acid phenethyl ester (CAPE), the main component of propolis, has various biological activities including anti-inflammatory effect and wound healing promotion. Odontoblasts located in the outermost layer of dental pulp play crucial roles such as production of growth factors and formation of hard tissue termed reparative dentin in host defense against dental caries. In this study, we investigated the effects of CAPE on the upregulation of vascular endothelial growth factor (VEGF) and calcification activities of odontoblasts, leading to development of novel therapy for dental pulp inflammation caused by dental caries. CAPE significantly induced mRNA expression and production of VEGF in rat clonal odontoblast-like KN-3 cells cultured in normal medium or osteogenic induction medium. CAPE treatment enhanced nuclear factor-kappa B (NF-κB) transcription factor activation, and furthermore, the specific inhibitor of NF-κB significantly reduced VEGF production. The expression of VEGF receptor- (VEGFR-) 2, not VEGFR-1, was up regulated in KN-3 cells treated with CAPE. In addition, VEGF significantly increased mineralization activity in KN-3 cells. These findings suggest that CAPE might be useful as a novel biological material for the dental pulp conservative therapy.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Hindawi","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2019 Hitomi Kuramoto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"23146133","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"23146141","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3376号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は, 著者Hitomi Kuramotoの学位論文として提出され, 学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院口腔科学教育部（口腔科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲口第455号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1155/2019/5390720"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1155/2019/5390720","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"362484"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"蔵本, 瞳","creatorNameLang":"ja"},{"creatorName":"クラモト, ヒトミ","creatorNameLang":"ja-Kana"},{"creatorName":"Kuramoto, Hitomi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"平尾, 功治","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"484","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"湯本, 浩通","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1691","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"細川, 由樹","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"909","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中西, 正","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1704","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武川, 大輔","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"566","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ワシオ, アヤコ","creatorNameLang":"ja"},{"creatorName":"ワシオ, アヤコ","creatorNameLang":"ja-Kana"},{"creatorName":"Washio, Ayako","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"キタムラ, チアキ","creatorNameLang":"ja"},{"creatorName":"キタムラ, チアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kitamura, Chiaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"松尾, 敬志","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1653","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-04-16"}],"displaytype":"detail","filename":"k3376_abstract.pdf","filesize":[{"value":"164 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Ester (CAPE) Induces VEGF Expression and Production in Rat Odontoblastic Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Caffeic Acid Phenethyl Ester (CAPE) Induces VEGF Expression and Production in Rat Odontoblastic Cells","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268556148"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-04-16"},"publish_date":"2020-04-16","publish_status":"0","recid":"2007500","relation_version_is_last":true,"title":["Caffeic Acid Phenethyl Ester (CAPE) Induces VEGF Expression and Production in Rat Odontoblastic Cells"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-30T09:29:23.454605+00:00"}