{"created":"2024-10-30T09:29:32.964251+00:00","id":2007504,"links":{},"metadata":{"_buckets":{"deposit":"4bbd8e8c-569b-4a67-bc6f-bcf7e0fb4297"},"_deposit":{"created_by":7,"id":"2007504","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007504"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007504","sets":["1713853213384:1713853295607"]},"author_link":["852"],"control_number":"2007504","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-08-23","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"3563","bibliographicPageStart":"3554","bibliographicVolumeNumber":"109","bibliographic_titles":[{"bibliographic_title":"Cancer Science","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Cisplatin plus 5‐fluorouracil is regarded as standard neoadjuvant chemotherapy for esophageal squamous cell carcinoma (ESCC) in Japan, but the prognosis remains poor. We have previously described how definitive chemoradiotherapy with docetaxel, nedaplatin, and 5‐fluorouracil (DNF) led to a very high response rate and promising survival times. We therefore undertook a phase II trial to evaluate the feasibility and efficacy of neoadjuvant DNF. The study included patients with clinical stage Ib‐III ESCC. Chemotherapy consisted of i.v. docetaxel (30 mg/m2) and nedaplatin (50 mg/m2) on days 1 and 8, and a continuous infusion of 5‐fluorouracil (400 mg/m2/day) on days 1‐5 and 8‐12, every 3 weeks. After three courses of chemotherapy, esophagectomy was carried out. The primary end‐point was the completion rate of the protocol treatment. Twenty‐eight patients were enrolled (cStage Ib/II/III, 2/3/23) and all received at least two cycles of chemotherapy. Twenty‐five patients underwent surgery, all of whom achieved an R0 resection, leading to a completion rate of 89.3%. The overall response rate was 87.0%. A pathological complete response was confirmed in eight (32.0%) cases. Grade 3/4 adverse events included leukopenia (32.1%), neutropenia (39.3%), febrile neutropenia (10.7%), thrombocytopenia (10.7%), and diarrhea (14.3%), but were manageable. Treatment‐related deaths and major surgical complications did not occur. Estimated 2‐year progression‐free and overall survival rates were 70.4% and 77.2%, respectively. Thus, DNF therapy was well tolerated and deemed feasible, with a strong tumor response in a neoadjuvant setting for ESCC. This trial is registered with the University Hospital Medical Information Network (UMIN ID: 000014305).","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Cancer Association","subitem_publisher_language":"en"},{"subitem_publisher":"John Wiley & Sons","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2018 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13497006","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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Hiroyuki","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"佐藤, 康史","creatorNameLang":"ja"},{"creatorName":"サトウ, ヤスシ","creatorNameLang":"ja-Kana"},{"creatorName":"Sato, Yasushi","creatorNameLang":"en"}],"familyNames":[{"familyName":"佐藤","familyNameLang":"ja"},{"familyName":"サトウ","familyNameLang":"ja-Kana"},{"familyName":"Sato","familyNameLang":"en"}],"givenNames":[{"givenName":"康史","givenNameLang":"ja"},{"givenName":"ヤスシ","givenNameLang":"ja-Kana"},{"givenName":"Yasushi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"852","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"321662/profile-ja.html","nameIdentifierScheme":"徳島大学 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Takahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヒラカワ, マサヒロ","creatorNameLang":"ja"},{"creatorName":"ヒラカワ, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Hirakawa, Masahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ミヤニシ, コウジ","creatorNameLang":"ja"},{"creatorName":"ミヤニシ, コウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyanishi, Koji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"サガワ, タモツ","creatorNameLang":"ja"},{"creatorName":"サガワ, タモツ","creatorNameLang":"ja-Kana"},{"creatorName":"Sagawa, Tamotsu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"フジカワ, コウシ","creatorNameLang":"ja"},{"creatorName":"フジカワ, コウシ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujikawa, Koshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オオイ, モトオ","creatorNameLang":"ja"},{"creatorName":"オオイ, モトオ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohi, Motoh","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オカガワ, ユタカ","creatorNameLang":"ja"},{"creatorName":"オカガワ, ユタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Okagawa, Yutaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ツジ, ヤスシ","creatorNameLang":"ja"},{"creatorName":"ツジ, ヤスシ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsuji, Yasushi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヒラヤマ, ミチアキ","creatorNameLang":"ja"},{"creatorName":"ヒラヤマ, ミチアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Hirayama, Michiaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イトウ, タツヤ","creatorNameLang":"ja"},{"creatorName":"イトウ, タツヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Ito, Tatsuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ノブオカ, タカユキ","creatorNameLang":"ja"},{"creatorName":"ノブオカ, タカユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Nobuoka, Takayuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タケマサ, イチロウ","creatorNameLang":"ja"},{"creatorName":"タケマサ, イチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Takemasa, Ichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"コブネ, マサヨシ","creatorNameLang":"ja"},{"creatorName":"コブネ, マサヨシ","creatorNameLang":"ja-Kana"},{"creatorName":"Kobune, Masayoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カトウ, ジュンジ","creatorNameLang":"ja"},{"creatorName":"カトウ, ジュンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Kato, Junji","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-12-09"}],"displaytype":"detail","filename":"cas_109_11_3554.pdf","filesize":[{"value":"248 KB"}],"format":"application/pdf","licensetype":"license_3","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007504/files/cas_109_11_3554.pdf"},"version_id":"15515143-ef70-4c65-9c3b-e9c65ad9d6c1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"docetaxel","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"esophageal cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"esophageal squamous cell carcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nedaplatin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neoadjuvant chemotherapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Neoadjuvant chemotherapy with docetaxel, nedaplatin, and fluorouracil for resectable esophageal cancer : A phase II study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Neoadjuvant chemotherapy with docetaxel, nedaplatin, and fluorouracil for resectable esophageal cancer : A phase II study","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-12-09"},"publish_date":"2020-12-09","publish_status":"0","recid":"2007504","relation_version_is_last":true,"title":["Neoadjuvant chemotherapy with docetaxel, nedaplatin, and fluorouracil for resectable esophageal cancer : A phase II study"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T12:22:21.157091+00:00"}