{"created":"2024-10-30T09:31:57.946293+00:00","id":2007536,"links":{},"metadata":{"_buckets":{"deposit":"6da2a5fa-3fec-4cdc-84dd-0b0e8034e7ed"},"_deposit":{"created_by":7,"id":"2007536","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007536"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007536","sets":["1713853213384:1713853295607"]},"author_link":["1700"],"control_number":"2007536","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-11-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"83","bibliographicPageStart":"77","bibliographicVolumeNumber":"139","bibliographic_titles":[{"bibliographic_title":"Journal of Pharmacological Sciences","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The beneficial effects of physical activity for pain are denominated exercise-induced hypoalgesia (EIH). Here, we examined the age-related change and potential role of the neurosteroid allopregnanolone (ALLO) on EIH in rats. Adult and aged rats were randomly divided into one of three groups; non-exercise control, Low-exercise, and High-exercise. The animals in the Low- and High-exercise groups were subjected to a 10-minute treadmill workout at 40% and 80% maximum oxygen intake intensity, respectively. In the Low-exercise groups, a significant EIH response was observed in aged but not in adult rats. The pre-treatment with ALLO synthesis inhibitor finasteride, but not opioid-receptor antagonist naloxone, inhibited the Low-exercise induced EIH response in aged rats. Furthermore, the Low-exercise increased brain ALLO levels in aged animals compared with controls, which was correlated with the mechanical pain sensitivity. On the other hand, High-exercise could induce EIH response in both adult and aged animals, but it was more effective in adult rats. The pre-treatment with naloxone, but not finasteride, reduced the EIH observed after High-exercise in both adult and aged rats. Our findings demonstrated that effective EIH can be achieved even by mild-intensity exercise in aged animals via an increase of the brain ALLO levels.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"},{"subitem_publisher":"Japanese Pharmacological Society","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13478613","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.jphs.2018.11.009"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.jphs.2018.11.009","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"356594"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"アオヤマ, ブン","creatorNameLang":"ja"},{"creatorName":"アオヤマ, ブン","creatorNameLang":"ja-Kana"},{"creatorName":"Aoyama, Bun","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カワノ, タカシ","creatorNameLang":"ja"},{"creatorName":"カワノ, タカシ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawano, Takashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イワタ, ヒデキ","creatorNameLang":"ja"},{"creatorName":"イワタ, ヒデキ","creatorNameLang":"ja-Kana"},{"creatorName":"Iwata, Hideki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ニシガキ, アツシ","creatorNameLang":"ja"},{"creatorName":"ニシガキ, アツシ","creatorNameLang":"ja-Kana"},{"creatorName":"Nishigaki, Atsushi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤマナカ, ダイキ","creatorNameLang":"ja"},{"creatorName":"ヤマナカ, ダイキ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamanaka, Daiki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タテイワ, ヒロキ","creatorNameLang":"ja"},{"creatorName":"タテイワ, ヒロキ","creatorNameLang":"ja-Kana"},{"creatorName":"Tateiwa, Hiroki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"シゲマツ, マリエ","creatorNameLang":"ja"},{"creatorName":"シゲマツ, マリエ","creatorNameLang":"ja-Kana"},{"creatorName":"Shigematsu-Locatelli, Marie","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"江口, 覚","creatorNameLang":"ja"},{"creatorName":"エグチ, サトル","creatorNameLang":"ja-Kana"},{"creatorName":"Eguchi, Satoru","creatorNameLang":"en"}],"familyNames":[{"familyName":"江口","familyNameLang":"ja"},{"familyName":"エグチ","familyNameLang":"ja-Kana"},{"familyName":"Eguchi","familyNameLang":"en"}],"givenNames":[{"givenName":"覚","givenNameLang":"ja"},{"givenName":"サトル","givenNameLang":"ja-Kana"},{"givenName":"Satoru","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1700","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60410/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60410/profile-ja.html"},{"nameIdentifier":"20263866","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=20263866"}]},{"creatorNames":[{"creatorName":"Locatelli, Fabricio M.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヨコヤマ, マサタカ","creatorNameLang":"ja"},{"creatorName":"ヨコヤマ, マサタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Yokoyama, Masataka","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-12-15"}],"displaytype":"detail","filename":"jphs_139_2_77.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007536/files/jphs_139_2_77.pdf"},"version_id":"5dd71cd4-4615-424c-85cd-dbc51e254b8a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Neurosteroid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Allopregnanolone","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Aging","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Exercise","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Acute pain","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal 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