{"created":"2024-10-30T09:32:50.677326+00:00","id":2007545,"links":{},"metadata":{"_buckets":{"deposit":"64d103c8-d34e-4de8-80c1-2cdadf48f05d"},"_deposit":{"created_by":7,"id":"2007545","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007545"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007545","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["424","301","1519"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"精巣内プロテアソームに会合する分子PITHD1の機能解析","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"PITHD1 is essential for male fertilization","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-01-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"1672","bibliographicPageStart":"1658","bibliographicVolumeNumber":"295","bibliographic_titles":[{"bibliographic_title":"Journal of Biological Chemistry","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The proteasome is a protein-degrading molecular complex that is necessary for protein homeostasis and various biological functions, including cell cycle regulation, signal transduction, and immune response. Proteasome activity is finely regulated by a variety of proteasome-interacting molecules. PITHD1 is a recently described molecule that has a domain putatively capable of interacting with the proteasome. However, it is unknown as to whether PITHD1 can actually bind to proteasomes and what it does in vivo. Here we report that PITHD1 is detected specifically in the spermatids in the testis and the cortical thymic epithelium in the thymus. Interestingly, PITHD1 associates with immunoproteasomes in the testis, but not with thymoproteasomes in the thymus. Mice deficient in PITHD1 exhibit severe male infertility accompanied with morphological abnormalities and impaired motility of spermatozoa. Furthermore, PITHD1 deficiency reduces proteasome activity in the testis and alters the amount of proteins that are important for fertilization capability by the sperm. However, the PITHD1-deficient mice demonstrate no detectable defects in the thymus, including T cell development. Collectively, our results identify PITHD1 as a proteasome-interacting protein that plays a nonredundant role in the male reproductive system.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Society for Biochemistry and Molecular Biology","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© the Author(s).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"1083351X","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA1202441X","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3360号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-02-27"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Hiroyuki Kondoの学位論文として提出され，学位審査・授与の対象となっている。\nThis research was originally published in the Journal of Biological Chemistry. Hiroyuki Kondo, Takafumi Matsumura, Mari Kaneko, Kenichi Inoue, Hidetaka Kosako, Masahito Ikawa, Yousuke Takahama, Izumi Ohigashi. PITHD1 is a proteasome-interacting protein essential for male fertilization. J Biol Chem. 2020, 295(6):1658-1672.\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1443号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1074/jbc.RA119.011144"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1074/jbc.RA119.011144","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"362983"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"近藤, 博之","creatorNameLang":"ja"},{"creatorName":"コンドウ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kondo, Hiroyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マツムラ, タカフミ","creatorNameLang":"ja"},{"creatorName":"マツムラ, タカフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsumura, Takafumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カネコ, マリ","creatorNameLang":"ja"},{"creatorName":"カネコ, マリ","creatorNameLang":"ja-Kana"},{"creatorName":"Kaneko, Mari","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イノウエ, ケンイチ","creatorNameLang":"ja"},{"creatorName":"イノウエ, ケンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Inoue, Kenichi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"小迫, 英尊","creatorNameLang":"ja"},{"creatorName":"コサコ, ヒデタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Kosako, 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cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"testis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sperm","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fertilization","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"PITHD1 is a proteasome-interacting protein essential for male fertilization","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PITHD1 is a proteasome-interacting protein essential for male 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