{"created":"2024-10-30T09:38:23.092406+00:00","id":2007606,"links":{},"metadata":{"_buckets":{"deposit":"f4aedd95-fd21-4735-8cac-33d24b586e33"},"_deposit":{"created_by":7,"id":"2007606","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007606"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007606","sets":["1713853213384:1713853296295:1716267877313:1716268556148"]},"author_link":["395","1261","713","1691","1669"],"control_number":"2007606","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"ショウガオールはヒト歯肉線維芽細胞において酸化ストレス反応の調節を介してAGEs誘導性のIL-6およびICAM-1産生を抑制する","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-10-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"20","bibliographicPageStart":"3705","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"Molecules","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Advanced glycation end-products (AGEs) cause diabetes mellitus (DM) complications and accumulate more highly in periodontal tissues of patients with periodontitis and DM. AGEs aggravate periodontitis with DM by increasing the expression of inflammation-related factors in periodontal tissues. 6-Shogaol, a major compound in ginger, has anti-inflammatory and anti-oxidative activities. However, the influence of shogaol on DM-associated periodontitis is not well known. In this study, the effects of 6-shogaol on AGEs-induced oxidative and anti-oxidative responses, and IL-6 and ICAM-1 expression in human gingival fibroblasts (HGFs) were investigated. When HGFs were cultured with 6-shogaol and AGEs, the activities of reactive oxygen species (ROS) and antioxidant enzymes (heme oxygenase-1 [HO-1] and NAD(P)H quinone dehydrogenase 1 [NQO1]), and IL-6 and ICAM-1 expressions were investigated. RAGE expression and phosphorylation of MAPKs and NF-κB were examined by western blotting. 6-Shogaol significantly inhibited AGEs-induced ROS activity, and increased HO-1 and NQO1 levels compared with the AGEs-treated cells. The AGEs-stimulated expression levels of receptor of AGE (RAGE), IL-6 and ICAM-1 and the phosphorylation of p38, ERK and p65 were attenuated by 6-shogaol. These results suggested that 6-shogaol inhibits AGEs-induced inflammatory responses by regulating oxidative and anti-oxidative activities and may have protective effects on periodontitis with DM.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14203049","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3377号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Kohei Nonakaの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院口腔科学教育部（口腔科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲口第456号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3390/molecules24203705"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/molecules24203705","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"362486"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"野中, 康平","creatorNameLang":"ja"},{"creatorName":"ノナカ, コウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"Nonaka, Kohei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"板東, 美香","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"395","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"坂本, 英次郎","creatorNameLang":"ja"},{"creatorName":"サカモト, エイジロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Sakamoto, Eijiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"稲垣, 裕司","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1261","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"成石, 浩司","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"713","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"湯本, 浩通","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1691","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木戸, 淳一","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1669","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-05-14"}],"displaytype":"detail","filename":"k3377_abstract.pdf","filesize":[{"value":"194 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2007606/files/k3377_abstract.pdf"},"version_id":"b76572aa-1038-412a-8826-0fa25487e13d"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-05-14"}],"displaytype":"detail","filename":"k3377_review.pdf","filesize":[{"value":"64.5 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2007606/files/k3377_review.pdf"},"version_id":"6f999729-ba76-475f-b641-0bfc4aacf725"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-05-14"}],"displaytype":"detail","filename":"k3377_fulltext.pdf","filesize":[{"value":"1.76 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007606/files/k3377_fulltext.pdf"},"version_id":"2126f0a5-2e13-4892-b533-f9ce79f15010"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"advanced glycation end-products","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"6-shogaol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ROS","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"antioxidant enzyme","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-6","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ICAM-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"human gingival fibroblasts","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"6-Shogaol Inhibits Advanced Glycation End-Products-Induced IL-6 and ICAM-1 Expression by Regulation Oxidative Responses in Human Gingival Fibroblasts","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"6-Shogaol Inhibits Advanced Glycation End-Products-Induced IL-6 and ICAM-1 Expression by Regulation Oxidative Responses in Human Gingival Fibroblasts","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268556148"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-05-14"},"publish_date":"2020-05-14","publish_status":"0","recid":"2007606","relation_version_is_last":true,"title":["6-Shogaol Inhibits Advanced Glycation End-Products-Induced IL-6 and ICAM-1 Expression by Regulation Oxidative Responses in Human Gingival Fibroblasts"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-20T06:10:31.731683+00:00"}