{"created":"2024-10-30T09:41:20.703097+00:00","id":2007640,"links":{},"metadata":{"_buckets":{"deposit":"4c80785a-3f74-4cf6-8fce-d044303f5191"},"_deposit":{"created_by":7,"id":"2007640","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007640"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007640","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["272","874","444"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Claudin-6は、腸型胃がんの亜群において独立した予後因子であるとともにがん促進遺伝子として機能する","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-10-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"417","bibliographicPageStart":"403","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"Gastric Cancer","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background\nWe aimed to identify novel tumor-promoting drivers highly expressed in gastric cancer (GC) that contribute to worsened prognosis in affected patients.\nMethods\nGenes whose expression was increased and correlated with worse prognosis in GC were screened using datasets from the Cancer Genome Atlas and Gene Expression Omnibus. We examined Claudin-6 (CLDN6) immunoreactivity in GC tissues and the effect of CLDN6 on cellular functions in GC cell lines. The mechanisms underlying GC-promoting function of CLDN6 were also investigated.\nResults\nCLDN6 was identified as a gene overexpressed in GC tumors as compared with adjacent non-tumorous tissues and whose increased expression was positively correlated with worse overall survival of GC patients, particularly those with Lauren’s intestinal type GC, in data from multiple publicly available datasets. Additionally, membranous CLDN6 immunoreactivity detected in intestinal type GC tumors was correlated with worse overall survival. In CLDN6-expressing GC cells, silencing of CLDN6 inhibited cell proliferation and migration/invasion abilities, possibly via suppressing transcription of YAP1 and its downstream transcriptional targets at least in part.\nConclusions:\nThis study identified CLDN6 as a GC-promoting gene, suggesting that CLDN6 to be a possible single prognostic marker and promising therapeutic target for a subset of GC patients.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The International Gastric Cancer Association","subitem_publisher_language":"en"},{"subitem_publisher":"The Japanese Gastric Cancer Association","subitem_publisher_language":"en"},{"subitem_publisher":"Springer naure","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14363305","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"14363291","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11316227","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3356号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Tomohiro Kohmotoの学位論文として提出され，学位審査・授与の対象となっている。\nThis is a post-peer-review, pre-copyedit version of an article published in Gastric Cancer.\nThe final authenticated version is available online at: https://doi.org/10.1007/s10120-019-01014-x\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1439号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1007/s10120-019-01014-x"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s10120-019-01014-x","subitem_relation_type_select":"DOI"}}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河本, 知大","creatorNameLang":"ja"},{"creatorName":"コウモト, トモヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Kohmoto, Tomohiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"増田, 清士","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"272","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ショウダ, カツトシ","creatorNameLang":"ja"},{"creatorName":"ショウダ, カツトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Shoda, Katsutoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タカハシ, リズ","creatorNameLang":"ja"},{"creatorName":"タカハシ, リズ","creatorNameLang":"ja-Kana"},{"creatorName":"Takahashi, Rizu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ウジロ, サエ","creatorNameLang":"ja"},{"creatorName":"ウジロ, サエ","creatorNameLang":"ja-Kana"},{"creatorName":"Ujiro, Sae","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"丹下, 正一朗","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"874","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"イチカワ, ダイスケ","creatorNameLang":"ja"},{"creatorName":"イチカワ, ダイスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Ichikawa, Daisuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オオツジ, エイゴ","creatorNameLang":"ja"},{"creatorName":"オオツジ, エイゴ","creatorNameLang":"ja-Kana"},{"creatorName":"Otsuji, Eigo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"井本, 逸勢","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"444","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-05-20"}],"displaytype":"detail","filename":"k3356_abstract_review.pdf","filesize":[{"value":"198 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2007640/files/k3356_abstract_review.pdf"},"version_id":"4a611bc5-7bf8-449c-9da3-82993b235171"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-10-26"}],"displaytype":"detail","filename":"k3356_fulltext.pdf","filesize":[{"value":"691 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007640/files/k3356_fulltext.pdf"},"version_id":"d5feefa2-e0f6-4c0f-ada4-1170fb673c2f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Claudin-6","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Stomach","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Neoplasms","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Prognosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Computer-simulation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Oncogenes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Stomach neoplasms","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Claudin-6 is a single prognostic marker and functions as a tumor-promoting gene in a subgroup of intestinal type gastric cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Claudin-6 is a single prognostic marker and functions as a tumor-promoting gene in a subgroup of intestinal type gastric cancer","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-05-20"},"publish_date":"2020-05-20","publish_status":"0","recid":"2007640","relation_version_is_last":true,"title":["Claudin-6 is a single prognostic marker and functions as a tumor-promoting gene in a subgroup of intestinal type gastric cancer"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-30T09:41:32.836964+00:00"}