{"created":"2024-10-30T09:42:28.051396+00:00","id":2007653,"links":{},"metadata":{"_buckets":{"deposit":"8782c643-d04a-4513-a3fd-96b1f084a981"},"_deposit":{"created_by":7,"id":"2007653","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007653"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007653","sets":["1713853213384:1713853296295:1716267878536:1716268699858"]},"author_link":["761","949","1274","866","1586","1583","1585"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"stearoyl-CoA desaturaseの低下は慢性腎臓病における過剰な小胞体ストレスを介して筋萎縮に寄与する","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-09-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"187","bibliographicPageStart":"179","bibliographicVolumeNumber":"67","bibliographic_titles":[{"bibliographic_title":"Journal of Clinical Biochemistry and Nutrition","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Skeletal muscle atrophy is associated with mortality and poor prognosis in patients with chronic kidney disease (CKD). However, underlying mechanism by which CKD causes muscle atrophy has not been completely understood. The quality of lipids (lipoquality), which is defined as the functional features of diverse lipid species, has recently been recognized as the pathology of various diseases. In this study, we investigated the roles of the stearoyl-CoA desaturase (SCD), which catalyzes the conversion of saturated fatty acids into monounsaturated fatty acids, in skeletal muscle on muscle atrophy in CKD model animals. In comparison to control rats, CKD rats decreased the SCD activity and its gene expression in atrophic gastrocnemius muscle. Next, oleic acid blocked the reduction of the thickness of C2C12 myotubes and the increase of the endoplasmic reticulum stress induced by SCD inhibitor. Furthermore, endoplasmic reticulum stress inhibitor ameliorated CKD-induced muscle atrophy (the weakness of grip strength and the decrease of muscle fiber size of gastrocnemius muscle) in mice and the reduction of the thickness of C2C12 myotubes by SCD inhibitor. These results suggest that the repression of SCD activity causes muscle atrophy through excessive endoplasmic reticulum stress in CKD.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Society for Free Radical Research Japan","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2020 Society for Free Radical Research Japan","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"09120009","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"18805086","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10710201","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3419号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（栄養学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Yuki Niidaの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院栄養生命科学教育部（人間栄養科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲栄第280号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3164/jcbn.20-24"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3164/jcbn.20-24","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"369577"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"新井田, 裕樹","creatorNameLang":"ja"},{"creatorName":"ニイダ, ユウキ","creatorNameLang":"ja-Kana"},{"creatorName":"Niida, Yuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"増田, 真志","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"761","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"アダチ, ユウイチロウ","creatorNameLang":"ja"},{"creatorName":"アダチ, ユウイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Adachi, Yuichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヨシザワ, アイカ","creatorNameLang":"ja"},{"creatorName":"ヨシザワ, アイカ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshizawa, Aika","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"大南, 博和","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"949","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"モリ, ユウキ","creatorNameLang":"ja"},{"creatorName":"モリ, ユウキ","creatorNameLang":"ja-Kana"},{"creatorName":"Mori, Yuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"大西, 康太","creatorNameLang":"ja"},{"creatorName":"オオニシ, コウタ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohnishi, Kohta","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"(山中)奥村, 仙示","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1274","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"内田, 貴之","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"866","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"二川, 健","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1586","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山本, 浩範","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1583","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ミヤザキ, マコト","creatorNameLang":"ja"},{"creatorName":"ミヤザキ, マコト","creatorNameLang":"ja-Kana"},{"creatorName":"Miyazaki, Makoto","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"竹谷, 豊","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1585","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-05-20"}],"displaytype":"detail","filename":"k3419_abstract_review.pdf","filesize":[{"value":"221 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2007653/files/k3419_abstract_review.pdf"},"version_id":"890a8646-10c1-4bab-b552-70053a89ad37"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-10-27"}],"displaytype":"detail","filename":"k3419_fulltext.pdf","filesize":[{"value":"778 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007653/files/k3419_fulltext.pdf"},"version_id":"1cbe9aeb-4ea8-444f-bd86-5b20ef4fce47"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"skeletal muscle atrophy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"endoplasmic reticulum (ER) stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chronic kidney disease (CKD)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"stearoyl-CoA desaturase (SCD)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"saturated fatty acid (SFA)","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Reduction of stearoyl-CoA desaturase (SCD) contributes muscle atrophy through the excess endoplasmic reticulum stress in chronic kidney disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Reduction of stearoyl-CoA desaturase (SCD) contributes muscle atrophy through the excess endoplasmic reticulum stress in chronic kidney disease","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268699858"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-05-20"},"publish_date":"2020-05-20","publish_status":"0","recid":"2007653","relation_version_is_last":true,"title":["Reduction of stearoyl-CoA desaturase (SCD) contributes muscle atrophy through the excess endoplasmic reticulum stress in chronic kidney disease"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-30T09:42:37.926950+00:00"}