{"created":"2024-10-30T09:43:45.780938+00:00","id":2007668,"links":{},"metadata":{"_buckets":{"deposit":"af50a16d-e33a-42ac-abb0-e306c74239a2"},"_deposit":{"created_by":7,"id":"2007668","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007668"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007668","sets":["1713829974766:1713854681789:1716364513953:1716365232625","1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["192","435","1631"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"妊娠中の血清ビオチン濃度は胎児の成長と早産に関連する","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Serum biotin level during pregnancy","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"173","bibliographicPageStart":"170","bibliographicVolumeNumber":"67","bibliographic_titles":[{"bibliographic_title":"The Journal of Medical Investigation","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background : Biotin is a water-soluble vitamin that plays various biological roles through histone modification, such as immune functions and fetal growth. Mammalian maternal biotin deficiency during gestation induces fetal growth restriction. Preterm infants are known to be marginal biotin deficiency. However, studies on the biotin status of pregnant women under various conditions are lacking. Method : This was a retrospective case control study to analyze serum biotin concentration during pregnancy and cord blood in normal pregnancy, preterm delivery and small-for-gestational-age (SGA). Results : Twenty pregnant women with normal term delivery, 35 with preterm delivery, 24 with SGA, and 10 non-pregnant adult women were enrolled. Serum biotin concentrations of pregnant women remained low from first to third trimester. The levels of serum biotin in cord blood showed a significant positive correlation with gestational age, and that of pregnant women showed a weak positive correlation with gestational age. The maternal serum biotin levels during second and third trimester of SGA group were significantly lower than those of normal term delivery. Conclusion : This study suggests that maternal biotin deficiency during pregnancy might be the risk of preterm labor or fetal growth restriction. Further studies are required to clarify the roles of biotin in perinatal medicine.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tokushima University Faculty of Medicine","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13496867","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12022913","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3368号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-03-18"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は, 著者Yuko Ichiharaの学位論文として提出され, 学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1451号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.2152/jmi.67.170"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2152/jmi.67.170","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"380299"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"市原, 裕子","creatorNameLang":"ja"},{"creatorName":"イチハラ, ユウコ","creatorNameLang":"ja-Kana"},{"creatorName":"Ichihara, Yuko","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"須賀, 健一","creatorNameLang":"ja"},{"creatorName":"スガ, ケンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Suga, Ken-ichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"須賀","familyNameLang":"ja"},{"familyName":"スガ","familyNameLang":"ja-Kana"},{"familyName":"Suga","familyNameLang":"en"}],"givenNames":[{"givenName":"健一","givenNameLang":"ja"},{"givenName":"ケンイチ","givenNameLang":"ja-Kana"},{"givenName":"Ken-ichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"435","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"207538/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/207538/profile-ja.html"},{"nameIdentifier":"70511335","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70511335"}]},{"creatorNames":[{"creatorName":"フクイ, マイカ","creatorNameLang":"ja"},{"creatorName":"フクイ, マイカ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukui, Maika","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"米谷, 直人","creatorNameLang":"ja"},{"creatorName":"ヨネタニ, ナオト","creatorNameLang":"ja-Kana"},{"creatorName":"Yonetani, Naoto","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ショウノ, ミキ","creatorNameLang":"ja"},{"creatorName":"ショウノ, ミキ","creatorNameLang":"ja-Kana"},{"creatorName":"Shono, Miki","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"中川, 竜二","creatorNameLang":"ja"},{"creatorName":"ナカガワ, リュウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakagawa, Ryuji","creatorNameLang":"en"}],"familyNames":[{"familyName":"中川","familyNameLang":"ja"},{"familyName":"ナカガワ","familyNameLang":"ja-Kana"},{"familyName":"Nakagawa","familyNameLang":"en"}],"givenNames":[{"givenName":"竜二","givenNameLang":"ja"},{"givenName":"リュウジ","givenNameLang":"ja-Kana"},{"givenName":"Ryuji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"192","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"121729/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/121729/profile-ja.html"},{"nameIdentifier":"10403685","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10403685"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"香美, 祥二","creatorNameLang":"ja"},{"creatorName":"カガミ, ショウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Kagami, Shoji","creatorNameLang":"en"}],"familyNames":[{"familyName":"香美","familyNameLang":"ja"},{"familyName":"カガミ","familyNameLang":"ja-Kana"},{"familyName":"Kagami","familyNameLang":"en"}],"givenNames":[{"givenName":"祥二","givenNameLang":"ja"},{"givenName":"ショウジ","givenNameLang":"ja-Kana"},{"givenName":"Shoji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1631","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60248/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60248/profile-ja.html"},{"nameIdentifier":"00224337","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=00224337"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-05-20"}],"displaytype":"detail","filename":"k3368_abstract_review.pdf","filesize":[{"value":"169 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2007668/files/k3368_abstract_review.pdf"},"version_id":"4b372224-9c3a-43f0-a41b-d1258b4142c1"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-06-10"}],"displaytype":"detail","filename":"k3368_fulltext.pdf","filesize":[{"value":"491 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007668/files/k3368_fulltext.pdf"},"version_id":"9116a91b-3ccf-4cae-bc86-c7a95c067c7e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"biotin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pregnancy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"preterm birth","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fetal growth restriction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"small for gestational age","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Serum biotin level during pregnancy is associated with fetal growth and preterm delivery","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Serum biotin level during pregnancy is associated with fetal growth and preterm delivery","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628","1716365232625"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-05-20"},"publish_date":"2020-05-20","publish_status":"0","recid":"2007668","relation_version_is_last":true,"title":["Serum biotin level during pregnancy is associated with fetal growth and preterm delivery"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-12T00:44:55.820089+00:00"}