{"created":"2024-10-30T09:46:56.226116+00:00","id":2007706,"links":{},"metadata":{"_buckets":{"deposit":"e6ce4d3d-a03b-4b92-b782-a42ca019de4a"},"_deposit":{"created_by":7,"id":"2007706","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007706"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007706","sets":["1713853213384:1713853295607"]},"author_link":["309"],"control_number":"2007706","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Diagnostic Criteria of FMD and NID","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-01-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageStart":"e013915","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"Journal of the American Heart Association","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background - Diagnostic criteria of flow-mediated vasodilation (FMD), an index of endothelial function, and nitroglycerin-induced vasodilation (NID), an index of vascular smooth muscle function, of the brachial artery have not been established. The purpose of this study was to propose diagnostic criteria of FMD and NID for normal endothelial function and normal vascular smooth muscle function.\nMethods and Results - We investigated the cutoff values of FMD and NID in subjects with (risk group) and those without cardiovascular risk factors or cardiovascular diseases (no-risk group) in 7277 Japanese subjects (mean age 51.4±10.8 years) from the Flow-Mediated Dilation Japan study and the Flow-Mediated Dilatation Japan Registry study for analysis of the cutoff value of FMD and in 1764 Japanese subjects (62.2±16.1 years) from the registry of Hiroshima University Hospital for analysis of the cutoff value of NID. Receiver-operator characteristic curve analysis of FMD to discriminate subjects in the no-risk group from patients in the risk group showed that the optimal cutoff value of FMD to diagnose subjects in the no-risk group was 7.1%. Receiver-operator characteristic curve analysis of NID to discriminate subjects in the no-risk group from patients in the risk group showed that the optimal cutoff value of NID to diagnose subjects in the no-risk group was 15.6%.\nConclusions - We propose that the cutoff value for normal endothelial function assessed by FMD of the brachial artery is 7.1% and that the cutoff value for normal vascular smooth muscle function assessed by NID of the brachial artery is 15.6% in Japanese subjects.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The American Heart Association","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is noncommercial and no modifications or adaptations are made.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20479980","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1161/JAHA.119.013915"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1161/JAHA.119.013915","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"363023"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"マルハシ, タツヤ","creatorNameLang":"ja"},{"creatorName":"マルハシ, タツヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Maruhashi, Tatsuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カジカワ, マサト","creatorNameLang":"ja"},{"creatorName":"カジカワ, マサト","creatorNameLang":"ja-Kana"},{"creatorName":"Kajikawa, Masato","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"キシモト, 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Yukihito","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-12-15"}],"displaytype":"detail","filename":"jaha_9_2_e013915.pdf","filesize":[{"value":"1.43 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007706/files/jaha_9_2_e013915.pdf"},"version_id":"570f15a6-94ee-422a-9e89-9b82c2ba62d5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"diagnostic criteria","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"endothelial function","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"flow-mediated vasodilation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nitroglycerin-induced vasodilation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"vascular smooth muscle function","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Diagnostic Criteria of Flow-Mediated Vasodilation for Normal Endothelial Function and Nitroglycerin-Induced Vasodilation for Normal Vascular Smooth Muscle Function of the Brachial Artery","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Diagnostic Criteria of Flow-Mediated Vasodilation for Normal Endothelial Function and Nitroglycerin-Induced Vasodilation for Normal Vascular Smooth Muscle Function of the Brachial Artery","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-12-15"},"publish_date":"2020-12-15","publish_status":"0","recid":"2007706","relation_version_is_last":true,"title":["Diagnostic Criteria of Flow-Mediated Vasodilation for Normal Endothelial Function and Nitroglycerin-Induced Vasodilation for Normal Vascular Smooth Muscle Function of the Brachial Artery"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T06:58:51.175494+00:00"}