{"created":"2024-10-30T09:47:32.842711+00:00","id":2007713,"links":{},"metadata":{"_buckets":{"deposit":"495af3ee-6255-49ed-889a-d93eff0d97db"},"_deposit":{"created_by":7,"id":"2007713","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007713"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007713","sets":["1713853213384:1713853295607"]},"author_link":["855"],"control_number":"2007713","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-01-19","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"300","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"Nature Communications","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Bone homeostasis is regulated by communication between bone-forming mature osteoblasts (mOBs) and bone-resorptive mature osteoclasts (mOCs). However, the spatial–temporal relationship and mode of interaction in vivo remain elusive. Here we show, by using an intravital imaging technique, that mOB and mOC functions are regulated via direct cell–cell contact between these cell types. The mOBs and mOCs mainly occupy discrete territories in the steady state, although direct cell–cell contact is detected in spatiotemporally limited areas. In addition, a pH-sensing fluorescence probe reveals that mOCs secrete protons for bone resorption when they are not in contact with mOBs, whereas mOCs contacting mOBs are non-resorptive, suggesting that mOBs can inhibit bone resorption by direct contact. Intermittent administration of parathyroid hormone causes bone anabolic effects, which lead to a mixed distribution of mOBs and mOCs, and increase cell–cell contact. This study reveals spatiotemporal intercellular interactions between mOBs and mOCs affecting bone homeostasis in vivo.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.\n© The Author(s) 2018","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20411723","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12645905","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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Junichi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"藤森, さゆ美","creatorNameLang":"ja"},{"creatorName":"フジモリ, サユミ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujimori, Sayumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"藤森","familyNameLang":"ja"},{"familyName":"フジモリ","familyNameLang":"ja-Kana"},{"familyName":"Fujimori","familyNameLang":"en"}],"givenNames":[{"givenName":"さゆ美","givenNameLang":"ja"},{"givenName":"サユミ","givenNameLang":"ja-Kana"},{"givenName":"Sayumi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"855","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"323108/profile-ja.html","nameIdentifierScheme":"徳島大学 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ユキヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Isogai, Yukihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カシイ, マサフミ","creatorNameLang":"ja"},{"creatorName":"カシイ, マサフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Kashii, Masafumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カイト, タカシ","creatorNameLang":"ja"},{"creatorName":"カイト, タカシ","creatorNameLang":"ja-Kana"},{"creatorName":"Kaito, Takashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オオバ, シンスケ","creatorNameLang":"ja"},{"creatorName":"オオバ, シンスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohba, Shinsuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Chung, Ung-il","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Lichtler, Alexander C.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"キクチ, カズヤ","creatorNameLang":"ja"},{"creatorName":"キクチ, カズヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Kikuchi, Kazuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マツダ, ヒデオ","creatorNameLang":"ja"},{"creatorName":"マツダ, ヒデオ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsuda, Hideo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヨシカワ, ヒデキ","creatorNameLang":"ja"},{"creatorName":"ヨシカワ, ヒデキ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshikawa, Hideki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イシイ, マサル","creatorNameLang":"ja"},{"creatorName":"イシイ, マサル","creatorNameLang":"ja-Kana"},{"creatorName":"Ishii, Masaru","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-12-25"}],"displaytype":"detail","filename":"ncomms_9_300.pdf","filesize":[{"value":"7.05 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