{"created":"2024-10-30T09:54:18.744741+00:00","id":2007804,"links":{},"metadata":{"_buckets":{"deposit":"383dc7ba-c114-4fa8-8c0a-3c03486e9d05"},"_deposit":{"created_by":7,"id":"2007804","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007804"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007804","sets":["1713853213384:1713853295607"]},"author_link":["1589","1631","1564","796"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-11-17","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"654","bibliographicPageStart":"648","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"Brain and Development","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose:\nTo evaluate the GABAA receptor in the autistic brain, we performed 123I-IMZ SPECT in patients with ASD. We compared 123I-IMZ SPECT abnormalities in patients who showed intellectual disturbance or focal epileptic discharge on EEG to those in patients without such findings.\nSubjects and methods:\nThe subjects consisted of 24 patients with ASD (mean age, 7.3±3.5years), including 9 with autistic disorder (mean age, 7.0±3.7years) and 15 with Asperger’s disorder (mean age, 7.5±3.2years). We used 10 non-symptomatic partial epilepsy patients (mean age, 7.8±3.6years) without intellectual delay as a control group.\nFor an objective evaluation of the 123I-IMZ SPECT results, we performed an SEE (Stereotactic Extraction Estimation) analysis to describe the decrease in accumulation in each brain lobule numerically.\nResults\nIn the comparison of the ASD group and the control group, there was a dramatic decrease in the accumulation of 123I-IMZ in the superior and medial frontal cortex. In the group with intellectual impairment and focal epileptic discharge on EEG, the decrease in accumulation in the superior and medial frontal cortex was greater than that in the group without these findings.\nConclusion\nThe present results suggest that disturbance of the GABAergic nervous system may contribute to the pathophysiology and aggravation of ASD, since the accumulation of 123I-IMZ was decreased in the superior and medial frontal cortex, which is considered to be associated with inference of the thoughts, feelings, and intentions of others (Theory of Mind).","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Japanese Society of Child Neurology","subitem_publisher_language":"en"},{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2011. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"03877604","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00111153","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA11521714","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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SPECT","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"γ-Aminobutyric acid (GABA)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Epilepsy","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Evaluation of the GABAergic nervous system in autistic brain : 123I-iomazenil SPECT study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Evaluation of the GABAergic nervous system in autistic brain : 123I-iomazenil SPECT study","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-06-24"},"publish_date":"2020-06-24","publish_status":"0","recid":"2007804","relation_version_is_last":true,"title":["Evaluation of the GABAergic nervous system in autistic brain : 123I-iomazenil SPECT study"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-12T00:44:52.700970+00:00"}