{"created":"2024-10-30T09:56:20.917656+00:00","id":2007834,"links":{},"metadata":{"_buckets":{"deposit":"7ceb26b0-6019-49c1-8327-7e30a4258d8f"},"_deposit":{"created_by":7,"id":"2007834","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007834"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007834","sets":["1713853213384:1713853295607"]},"author_link":["309"],"control_number":"2007834","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"BMCs and periodontal tissue healing","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-21","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"19","bibliographicVolumeNumber":"2","bibliographic_titles":[{"bibliographic_title":"Frontiers in Cell and Developmental Biology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Bone marrow-derived cells (BMCs) are considered to be a major source of mesenchymal stem cells (MSCs) in adults and are known to be effective in periodontal tissue regeneration. However, whether endogenous BMCs are involved in periodontal tissue repair process is uncertain. We therefore created periodontal tissue defects in the buccal alveolar bone of mandibular first molars in bone marrow chimeric mice, and immunohistochemically examined the expression of stromal cell derived factor-1 (SDF-1) and the mobilization of BMCs. We found that SDF-1 expression was increased around the defects at as early as 1 week after injury and that BMCs were mobilized to the defects, while GFP+/CD45+ were rarely observed. Fluorescence-activated cell sorting (FACS) analysis demonstrated that the number of platelet-derived growth factor receptor (pdgfr) α+/Sca-1+ (PαS) cells in the bone marrow decreased after injury. Taken together, these results suggest that BMCs are mobilized to the periodontal tissue defects. Recruitment of BMCs, including a subset of MSCs could be a new target of periodontal treatment.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Frontiers Media S.A.","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2014 Kimura, Komaki, Iwasaki, Sata, Izumi and Morita. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"2296634X","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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ケンゴ","creatorNameLang":"ja"},{"creatorName":"イワサキ, ケンゴ","creatorNameLang":"ja-Kana"},{"creatorName":"Iwasaki, Kengo","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"佐田, 政隆","creatorNameLang":"ja"},{"creatorName":"サタ, マサタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Sata, Masataka","creatorNameLang":"en"}],"familyNames":[{"familyName":"佐田","familyNameLang":"ja"},{"familyName":"サタ","familyNameLang":"ja-Kana"},{"familyName":"Sata","familyNameLang":"en"}],"givenNames":[{"givenName":"政隆","givenNameLang":"ja"},{"givenName":"マサタカ","givenNameLang":"ja-Kana"},{"givenName":"Masataka","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"309","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"173932/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/173932/profile-ja.html"},{"nameIdentifier":"80345214","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80345214"}]},{"creatorNames":[{"creatorName":"イズミ, ユウイチ","creatorNameLang":"ja"},{"creatorName":"イズミ, ユウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Izumi, Yuichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"モリタ, イクオ","creatorNameLang":"ja"},{"creatorName":"モリタ, イクオ","creatorNameLang":"ja-Kana"},{"creatorName":"Morita, Ikuo","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-07-16"}],"displaytype":"detail","filename":"fcell_2_19.pdf","filesize":[{"value":"2.33 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007834/files/fcell_2_19.pdf"},"version_id":"1d68d9dd-824f-44e1-b567-23e7e540404c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"bone marrow chimeric mice","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"periodontal defects","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mesenchymal stem cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"recruitment","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"SDF-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Recruitment of bone marrow-derived cells to periodontal tissue defects","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Recruitment of bone marrow-derived cells to periodontal tissue defects","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-07-16"},"publish_date":"2020-07-16","publish_status":"0","recid":"2007834","relation_version_is_last":true,"title":["Recruitment of bone marrow-derived cells to periodontal tissue defects"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T06:58:47.725254+00:00"}