{"created":"2024-10-30T10:07:00.549930+00:00","id":2007964,"links":{},"metadata":{"_buckets":{"deposit":"73f233ec-de9a-47c0-b88f-363a6608016c"},"_deposit":{"created_by":7,"id":"2007964","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007964"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007964","sets":["1713853213384:1713853295607"]},"author_link":["316"],"control_number":"2007964","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Cancer Immunol Immunother","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-10-18","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"24","bibliographicPageStart":"17","bibliographicVolumeNumber":"66","bibliographic_titles":[{"bibliographic_title":"Cancer Immunology, Immunotherapy","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose\nThrough genome-wide expression profile analysis, hypoxia-inducible protein 2 (HIG2) has previously been identified as an oncoprotein involved in development/progression of renal cell carcinoma (RCC). We subsequently identified a highly immunogenic HLA-A*0201/0206-restricted epitope peptide (HIG2-9-4) corresponding to a part of HIG2 and applied it as a therapeutic vaccine. We conducted a phase I clinical trial using the HIG2-9-4 peptide for patients with advanced RCC.\nMaterials and Methods\nNine patients having HLA-A*0201 or HLA-A*0206 with metastatic or unresectable RCC after failure of the cytokine and/or tyrosine kinase inhibitor therapies were enrolled in this study. The patients received subcutaneous administration of the peptide as an emulsion form with Montanide ISA-51 VG once a week in a dose-escalation manner (doses of 0.5, 1.0, or 3.0 mg/body, 3 patients for each dose). The primary endpoint was safety, and the secondary endpoints were immunological and clinical responses.\nResults\nVaccinations with HIG2-9-4 peptide could be well tolerated without any serious systemic adverse events. Peptide-specific cytotoxic T lymphocyte (CTL) responses were detected in eight of the nine patients. Doses of 1.0 or 3.0 mg/body seemed to induce a CTL response better than did a dose of 0.5 mg/body, although the number of patients was too small to draw a firm conclusion. The disease control rate (stable disease for ≥4 months) was 77.8 %, and the median progression-free survival time was 10.3 months.\nConclusions\nHIG2-9-4 peptide vaccine treatment was tolerable and effectively induced peptide-specific CTLs in RCC patients. This novel peptide vaccine therapy for RCC is promising.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"03407004","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"14320851","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00598499","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1007/s00262-016-1915-5"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s00262-016-1915-5","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"321073"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"オバラ, ワタル","creatorNameLang":"ja"},{"creatorName":"オバラ, ワタル","creatorNameLang":"ja-Kana"},{"creatorName":"Obara, Wataru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カラシマ, タカシ","creatorNameLang":"ja"},{"creatorName":"カラシマ, タカシ","creatorNameLang":"ja-Kana"},{"creatorName":"Karashima, Takashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タケダ, カズヨシ","creatorNameLang":"ja"},{"creatorName":"タケダ, カズヨシ","creatorNameLang":"ja-Kana"},{"creatorName":"Takeda, Kazuyoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カトウ, レンペイ","creatorNameLang":"ja"},{"creatorName":"カトウ, レンペイ","creatorNameLang":"ja-Kana"},{"creatorName":"Kato, Renpei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カトウ, ヨウイチロウ","creatorNameLang":"ja"},{"creatorName":"カトウ, ヨウイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Kato, Yoichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カネヒラ, ミツグ","creatorNameLang":"ja"},{"creatorName":"カネヒラ, ミツグ","creatorNameLang":"ja-Kana"},{"creatorName":"Kanehira, Mitsugu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タカタ, リョウ","creatorNameLang":"ja"},{"creatorName":"タカタ, リョウ","creatorNameLang":"ja-Kana"},{"creatorName":"Takata, Ryo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イノウエ, ケイジ","creatorNameLang":"ja"},{"creatorName":"イノウエ, ケイジ","creatorNameLang":"ja-Kana"},{"creatorName":"Inoue, Keiji","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"片桐, 豊雅","creatorNameLang":"ja"},{"creatorName":"カタギリ, トヨマサ","creatorNameLang":"ja-Kana"},{"creatorName":"Katagiri, Toyomasa","creatorNameLang":"en"}],"familyNames":[{"familyName":"片桐","familyNameLang":"ja"},{"familyName":"カタギリ","familyNameLang":"ja-Kana"},{"familyName":"Katagiri","familyNameLang":"en"}],"givenNames":[{"givenName":"豊雅","givenNameLang":"ja"},{"givenName":"トヨマサ","givenNameLang":"ja-Kana"},{"givenName":"Toyomasa","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"316","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"174774/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/174774/profile-ja.html"},{"nameIdentifier":"60291895","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60291895"}]},{"creatorNames":[{"creatorName":"シュウイン, タロウ","creatorNameLang":"ja"},{"creatorName":"シュウイン, タロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Shuin, Taro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ナカムラ, ユウスケ","creatorNameLang":"ja"},{"creatorName":"ナカムラ, ユウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakamura, Yusuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"フジオカ, トモアキ","creatorNameLang":"ja"},{"creatorName":"フジオカ, トモアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujioka, Tomoaki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-10-26"}],"displaytype":"detail","filename":"cii_66_1_17.pdf","filesize":[{"value":"805 KB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007964/files/cii_66_1_17.pdf"},"version_id":"d2069723-0c28-42c5-b0a0-2ba41bce9eaf"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cancer peptide vaccine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Genome-wide expression profile","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cytotoxic T lymphocyte","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Renal cell carcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effective induction of cytotoxic T cells recognizing an epitope peptide derived from hypoxia-inducible protein 2 (HIG2) in patients with metastatic renal cell carcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effective induction of cytotoxic T cells recognizing an epitope peptide derived from hypoxia-inducible protein 2 (HIG2) in patients with metastatic renal cell carcinoma","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-10-26"},"publish_date":"2020-10-26","publish_status":"0","recid":"2007964","relation_version_is_last":true,"title":["Effective induction of cytotoxic T cells recognizing an epitope peptide derived from hypoxia-inducible protein 2 (HIG2) in patients with metastatic renal cell carcinoma"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-27T07:24:30.554655+00:00"}