{"created":"2024-10-30T10:07:41.923669+00:00","id":2007971,"links":{},"metadata":{"_buckets":{"deposit":"e46602da-ee6a-4273-8255-a7821a832799"},"_deposit":{"created_by":7,"id":"2007971","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007971"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007971","sets":["1713853213384:1713853296295:1716267877313:1716268556148"]},"author_link":["230","1634","450","1591","326","528","384","723","919","1164","876","950","323","580"],"control_number":"2007971","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"RANKLが誘導する破骨細胞分化におけるROSの役割と、Febuxostatによる破骨細胞分化抑制効果","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-04-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageStart":"929","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"Cancers","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Receptor activator of NF-κB ligand (RANKL), a critical mediator of osteoclastogenesis, is upregulated in multiple myeloma (MM). The xanthine oxidase inhibitor febuxostat, clinically used for prevention of tumor lysis syndrome, has been demonstrated to effectively inhibit not only the generation of uric acid but also the formation of reactive oxygen species (ROS). ROS has been demonstrated to mediate RANKL-mediated osteoclastogenesis. In the present study, we therefore explored the role of cancer-treatment-induced ROS in RANKL-mediated osteoclastogenesis and the suppressive effects of febuxostat on ROS generation and osteoclastogenesis. RANKL dose-dependently induced ROS production in RAW264.7 preosteoclastic cells; however, febuxostat inhibited the RANKL-induced ROS production and osteoclast (OC) formation. Interestingly, doxorubicin (Dox) further enhanced RANKL-induced osteoclastogenesis through upregulation of ROS production, which was mostly abolished by addition of febuxostat. Febuxostat also inhibited osteoclastogenesis enhanced in cocultures of bone marrow cells with MM cells. Importantly, febuxostat rather suppressed MM cell viability and did not compromise Dox’s anti-MM activity. In addition, febuxostat was able to alleviate pathological osteoclastic activity and bone loss in ovariectomized mice. Collectively, these results suggest that excessive ROS production by aberrant RANKL overexpression and/or anticancer treatment disadvantageously impacts bone, and that febuxostat can prevent the ROS-mediated osteoclastic bone damage.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20726694","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3467号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-12-10"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Mohannad Ashtarの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院口腔科学教育部（口腔科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲口第466号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3390/cancers12040929"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/cancers12040929","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"365352"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"アシテル, モハナッド","creatorNameLang":"ja"},{"creatorName":"アシテル, モハナッド","creatorNameLang":"ja-Kana"},{"creatorName":"Ashtar, Mohannad","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"天眞, 寛文","creatorNameLang":"ja"},{"creatorName":"テンシン, ヒロフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Tenshin, Hirofumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"天眞","familyNameLang":"ja"},{"familyName":"テンシン","familyNameLang":"ja-Kana"},{"familyName":"Tenshin","familyNameLang":"en"}],"givenNames":[{"givenName":"寛文","givenNameLang":"ja"},{"givenName":"ヒロフミ","givenNameLang":"ja-Kana"},{"givenName":"Hirofumi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"723","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"281316/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/281316/profile-ja.html"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"寺町, 順平","creatorNameLang":"ja"},{"creatorName":"テラマチ, ジュンペイ","creatorNameLang":"ja-Kana"},{"creatorName":"Teramachi, Jumpei","creatorNameLang":"en"}],"familyNames":[{"familyName":"寺町","familyNameLang":"ja"},{"familyName":"テラマチ","familyNameLang":"ja-Kana"},{"familyName":"Teramachi","familyNameLang":"en"}],"givenNames":[{"givenName":"順平","givenNameLang":"ja"},{"givenName":"ジュンペイ","givenNameLang":"ja-Kana"},{"givenName":"Jumpei","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"384","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"189914/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/189914/profile-ja.html"},{"nameIdentifier":"20515986","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=20515986"}]},{"creatorNames":[{"creatorName":"Bat-Erdene, Ariunzaya","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"日浅, 雅博","creatorNameLang":"ja"},{"creatorName":"ヒアサ, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Hiasa, Masahiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"日浅","familyNameLang":"ja"},{"familyName":"ヒアサ","familyNameLang":"ja-Kana"},{"familyName":"Hiasa","familyNameLang":"en"}],"givenNames":[{"givenName":"雅博","givenNameLang":"ja"},{"givenName":"マサヒロ","givenNameLang":"ja-Kana"},{"givenName":"Masahiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"326","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"174880/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/174880/profile-ja.html"},{"nameIdentifier":"90511337","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=90511337"}]},{"creatorNames":[{"creatorName":"オダ, アスカ","creatorNameLang":"ja"},{"creatorName":"オダ, アスカ","creatorNameLang":"ja-Kana"},{"creatorName":"Oda, Asuka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"谷本, 幸多朗","creatorNameLang":"ja"},{"creatorName":"タニモト, コウタロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanimoto, Kotaro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"清水, 宗","creatorNameLang":"ja"},{"creatorName":"シミズ, ソウ","creatorNameLang":"ja-Kana"},{"creatorName":"Shimizu, So","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヒガ, ヨシキ","creatorNameLang":"ja"},{"creatorName":"ヒガ, ヨシキ","creatorNameLang":"ja-Kana"},{"creatorName":"Higa, Yoshiki","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"原田, 武志","creatorNameLang":"ja"},{"creatorName":"ハラダ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Harada, Takeshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"原田","familyNameLang":"ja"},{"familyName":"ハラダ","familyNameLang":"ja-Kana"},{"familyName":"Harada","familyNameLang":"en"}],"givenNames":[{"givenName":"武志","givenNameLang":"ja"},{"givenName":"タケシ","givenNameLang":"ja-Kana"},{"givenName":"Takeshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"876","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"323782/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/323782/profile-ja.html"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"大浦, 雅博","creatorNameLang":"ja"},{"creatorName":"オオウラ, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Oura, Masahiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"大浦","familyNameLang":"ja"},{"familyName":"オオウラ","familyNameLang":"ja-Kana"},{"familyName":"Oura","familyNameLang":"en"}],"givenNames":[{"givenName":"雅博","givenNameLang":"ja"},{"givenName":"マサヒロ","givenNameLang":"ja-Kana"},{"givenName":"Masahiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"950","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"349366/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/349366/profile-ja.html"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"曽我部, 公子","creatorNameLang":"ja"},{"creatorName":"ソガベ, キミコ","creatorNameLang":"ja-Kana"},{"creatorName":"Sogabe, Kimiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"曽我部","familyNameLang":"ja"},{"familyName":"ソガベ","familyNameLang":"ja-Kana"},{"familyName":"Sogabe","familyNameLang":"en"}],"givenNames":[{"givenName":"公子","givenNameLang":"ja"},{"givenName":"キミコ","givenNameLang":"ja-Kana"},{"givenName":"Kimiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"919","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"337582/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/337582/profile-ja.html"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"中村, 信元","creatorNameLang":"ja"},{"creatorName":"ナカムラ, シンゲン","creatorNameLang":"ja-Kana"},{"creatorName":"Nakamura, Shingen","creatorNameLang":"en"}],"familyNames":[{"familyName":"中村","familyNameLang":"ja"},{"familyName":"ナカムラ","familyNameLang":"ja-Kana"},{"familyName":"Nakamura","familyNameLang":"en"}],"givenNames":[{"givenName":"信元","givenNameLang":"ja"},{"givenName":"シンゲン","givenNameLang":"ja-Kana"},{"givenName":"Shingen","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"528","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"229265/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/229265/profile-ja.html"},{"nameIdentifier":"10511321","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10511321"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"藤井, 志朗","creatorNameLang":"ja"},{"creatorName":"フジイ, シロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujii, Shiroh","creatorNameLang":"en"}],"familyNames":[{"familyName":"藤井","familyNameLang":"ja"},{"familyName":"フジイ","familyNameLang":"ja-Kana"},{"familyName":"Fujii","familyNameLang":"en"}],"givenNames":[{"givenName":"志朗","givenNameLang":"ja"},{"givenName":"シロウ","givenNameLang":"ja-Kana"},{"givenName":"Shiroh","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"450","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"208060/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/208060/profile-ja.html"},{"nameIdentifier":"618473","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=618473"}]},{"creatorNames":[{"creatorName":"住谷, 龍平","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1164","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"三木, 浩和","creatorNameLang":"ja"},{"creatorName":"ミキ, ヒロカズ","creatorNameLang":"ja-Kana"},{"creatorName":"Miki, Hirokazu","creatorNameLang":"en"}],"familyNames":[{"familyName":"三木","familyNameLang":"ja"},{"familyName":"ミキ","familyNameLang":"ja-Kana"},{"familyName":"Miki","familyNameLang":"en"}],"givenNames":[{"givenName":"浩和","givenNameLang":"ja"},{"givenName":"ヒロカズ","givenNameLang":"ja-Kana"},{"givenName":"Hirokazu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"580","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"246784/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/246784/profile-ja.html"},{"nameIdentifier":"50511333","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=50511333"}]},{"creatorNames":[{"creatorName":"ウダカ, ケンゴ","creatorNameLang":"ja"},{"creatorName":"ウダカ, ケンゴ","creatorNameLang":"ja-Kana"},{"creatorName":"Udaka, Kengo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タカハシ, マミコ","creatorNameLang":"ja"},{"creatorName":"タカハシ, マミコ","creatorNameLang":"ja-Kana"},{"creatorName":"Takahashi, Mamiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"賀川, 久美子","creatorNameLang":"ja"},{"creatorName":"カガワ, クミコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kagawa, Kumiko","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"遠藤, 逸朗","creatorNameLang":"ja"},{"creatorName":"エンドウ, イツロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Endo, Itsuro","creatorNameLang":"en"}],"familyNames":[{"familyName":"遠藤","familyNameLang":"ja"},{"familyName":"エンドウ","familyNameLang":"ja-Kana"},{"familyName":"Endo","familyNameLang":"en"}],"givenNames":[{"givenName":"逸朗","givenNameLang":"ja"},{"givenName":"イツロウ","givenNameLang":"ja-Kana"},{"givenName":"Itsuro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"230","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"145663/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/145663/profile-ja.html"},{"nameIdentifier":"10432759","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10432759"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"田中, 栄二","creatorNameLang":"ja"},{"creatorName":"タナカ, エイジ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanaka, Eiji","creatorNameLang":"en"}],"familyNames":[{"familyName":"田中","familyNameLang":"ja"},{"familyName":"タナカ","familyNameLang":"ja-Kana"},{"familyName":"Tanaka","familyNameLang":"en"}],"givenNames":[{"givenName":"栄二","givenNameLang":"ja"},{"givenName":"エイジ","givenNameLang":"ja-Kana"},{"givenName":"Eiji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"323","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"174876/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/174876/profile-ja.html"},{"nameIdentifier":"40273693","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40273693"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"松本, 俊夫","creatorNameLang":"ja"},{"creatorName":"マツモト, トシオ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsumoto, Toshio","creatorNameLang":"en"}],"familyNames":[{"familyName":"松本","familyNameLang":"ja"},{"familyName":"マツモト","familyNameLang":"ja-Kana"},{"familyName":"Matsumoto","familyNameLang":"en"}],"givenNames":[{"givenName":"俊夫","givenNameLang":"ja"},{"givenName":"トシオ","givenNameLang":"ja-Kana"},{"givenName":"Toshio","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1591","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60162/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60162/profile-ja.html"},{"nameIdentifier":"20157374","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=20157374"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"安倍, 正博","creatorNameLang":"ja"},{"creatorName":"アベ, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Abe, Masahiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"安倍","familyNameLang":"ja"},{"familyName":"アベ","familyNameLang":"ja-Kana"},{"familyName":"Abe","familyNameLang":"en"}],"givenNames":[{"givenName":"正博","givenNameLang":"ja"},{"givenName":"マサヒロ","givenNameLang":"ja-Kana"},{"givenName":"Masahiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1634","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60265/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60265/profile-ja.html"},{"nameIdentifier":"80263812","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80263812"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"k3467_abstract.pdf","filesize":[{"value":"129 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2007971/files/k3467_abstract.pdf"},"version_id":"07cdca87-ee17-4a8d-bef0-10ec25463170"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"k3467_review.pdf","filesize":[{"value":"70.2 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2007971/files/k3467_review.pdf"},"version_id":"8323c963-80bc-493e-85dd-08d8bef63842"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-10-29"}],"displaytype":"detail","filename":"k3467_fulltext.pdf","filesize":[{"value":"4 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007971/files/k3467_fulltext.pdf"},"version_id":"885887e1-4aa3-41d5-a8cb-1ef8b8973d6d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"RANKL","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ROS","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"doxorubicin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"multiple myeloma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"osteoclastogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ovariectomy","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"The Roles of ROS Generation in RANKL-Induced Osteoclastogenesis : Suppressive Effects of Febuxostat","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The Roles of ROS Generation in RANKL-Induced Osteoclastogenesis : Suppressive Effects of Febuxostat","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268556148"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-10-29"},"publish_date":"2020-10-29","publish_status":"0","recid":"2007971","relation_version_is_last":true,"title":["The Roles of ROS Generation in RANKL-Induced Osteoclastogenesis : Suppressive Effects of Febuxostat"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T12:52:46.649450+00:00"}