{"created":"2024-10-30T10:08:20.998396+00:00","id":2007979,"links":{},"metadata":{"_buckets":{"deposit":"bfadfba7-4a6f-4fd8-b9bf-aa23403b76e2"},"_deposit":{"created_by":7,"id":"2007979","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007979"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007979","sets":["1713853213384:1713853295607"]},"author_link":["424","855","850","810","316","301","1519"],"control_number":"2007979","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-11-26","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"2916","bibliographicPageStart":"2901","bibliographicVolumeNumber":"29","bibliographic_titles":[{"bibliographic_title":"Cell Reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The thymic function to produce self-protective and self-tolerant T cells is chiefly mediated by cortical thymic epithelial cells (cTECs) and medullary TECs (mTECs). Recent studies including single-cell transcriptomic analyses have highlighted a rich diversity in functional mTEC subpopulations. Because of their limited cellularity, however, the biochemical characterization of TECs, including the proteomic profiling of cTECs and mTECs, has remained unestablished. Utilizing genetically modified mice that carry enlarged but functional thymuses, here we show a combination of proteomic and transcriptomic profiles for cTECs and mTECs, which identified signature molecules that characterize a developmental and functional contrast between cTECs and mTECs. Our results reveal a highly specific impact of the thymoproteasome on proteasome subunit composition in cTECs and provide an integrated trans-omics platform for further exploration of thymus biology.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"22111247","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.celrep.2019.10.079"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.celrep.2019.10.079","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"361076"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大東, いずみ","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"424","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"タナカ, ユウ","creatorNameLang":"ja"},{"creatorName":"タナカ, ユウ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanaka, Yu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"近藤, 健太","creatorNameLang":"ja"},{"creatorName":"コンドウ, ケンタ","creatorNameLang":"ja-Kana"},{"creatorName":"Kondo, Kenta","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"藤森, さゆ美","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"855","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"コンドウ, ヒロユキ","creatorNameLang":"ja"},{"creatorName":"コンドウ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kondo, Hiroyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Palin, Amy C.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hoffmann, Victoria","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"香西, 美奈","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"850","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松下, 洋輔","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"810","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ウダ, シンスケ","creatorNameLang":"ja"},{"creatorName":"ウダ, シンスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Uda, Shinsuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"モトスギ, リョウ","creatorNameLang":"ja"},{"creatorName":"モトスギ, リョウ","creatorNameLang":"ja-Kana"},{"creatorName":"Motosugi, Ryo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハマザキ, ジュン","creatorNameLang":"ja"},{"creatorName":"ハマザキ, ジュン","creatorNameLang":"ja-Kana"},{"creatorName":"Hamazaki, Jun","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"クボタ, ヒロユキ","creatorNameLang":"ja"},{"creatorName":"クボタ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kubota, Hiroyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ムラタ, シゲオ","creatorNameLang":"ja"},{"creatorName":"ムラタ, シゲオ","creatorNameLang":"ja-Kana"},{"creatorName":"Murata, Shigeo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タナカ, ケイジ","creatorNameLang":"ja"},{"creatorName":"タナカ, ケイジ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanaka, Keiji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"片桐, 豊雅","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"316","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小迫, 英尊","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"301","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高浜, 洋介","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1519","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-10-29"}],"displaytype":"detail","filename":"celrep_29_9_2901.pdf","filesize":[{"value":"5.28 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007979/files/celrep_29_9_2901.pdf"},"version_id":"acf8fd2d-f8c1-4b5c-a358-c262f12a0b01"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-10-29"},"publish_date":"2020-10-29","publish_status":"0","recid":"2007979","relation_version_is_last":true,"title":["Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-13T00:38:26.712991+00:00"}