{"created":"2024-10-30T10:08:25.020803+00:00","id":2007980,"links":{},"metadata":{"_buckets":{"deposit":"835eedc6-b81a-4a0a-9417-ae5fd3819a0c"},"_deposit":{"created_by":7,"id":"2007980","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007980"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007980","sets":["1713853213384:1713853295607"]},"author_link":["305"],"control_number":"2007980","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-10-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"1203","bibliographicPageStart":"1193","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"Cell Reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Brown adipocyte activation or beige adipocyte emergence in white adipose tissue (WAT) increases energy expenditure, leading to a reduction in body fat mass and improved glucose metabolism. We found that activin E functions as a hepatokine that enhances thermogenesis in response to cold exposure through beige adipocyte emergence in inguinal WAT (ingWAT). Hepatic activin E overexpression activated thermogenesis through Ucp1 upregulation in ingWAT and other adipose tissues including interscapular brown adipose tissue and mesenteric WAT. Hepatic activin E-transgenic mice exhibited improved insulin sensitivity. Inhibin βE gene silencing inhibited cold-induced Ucp1 induction in ingWAT. Furthermore, in vitro experiments suggested that activin E directly stimulated expression of Ucp1 and Fgf21, which was mediated by transforming growth factor-β or activin type I receptors. We uncovered a function of activin E to stimulate energy expenditure through brown and beige adipocyte activation, suggesting a possible preventive or therapeutic target for obesity.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"22111247","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.celrep.2018.10.008"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.celrep.2018.10.008","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"354382"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ハシモト, オサム","creatorNameLang":"ja"},{"creatorName":"ハシモト, オサム","creatorNameLang":"ja-Kana"},{"creatorName":"Hashimoto, Osamu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"フナバ, マサユキ","creatorNameLang":"ja"},{"creatorName":"フナバ, マサユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Funaba, Masayuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"セキヤマ, カズナリ","creatorNameLang":"ja"},{"creatorName":"セキヤマ, カズナリ","creatorNameLang":"ja-Kana"},{"creatorName":"Sekiyama, Kazunari","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ドイ, サトル","creatorNameLang":"ja"},{"creatorName":"ドイ, サトル","creatorNameLang":"ja-Kana"},{"creatorName":"Doi, Satoru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"シンドウ, ダイチ","creatorNameLang":"ja"},{"creatorName":"シンドウ, ダイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Shindo, Daichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"サトウ, リョウ","creatorNameLang":"ja"},{"creatorName":"サトウ, リョウ","creatorNameLang":"ja-Kana"},{"creatorName":"Satoh, Ryo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イトイ, ヒロシ","creatorNameLang":"ja"},{"creatorName":"イトイ, ヒロシ","creatorNameLang":"ja-Kana"},{"creatorName":"Itoi, Hiroshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オオイワ, ヒロアキ","creatorNameLang":"ja"},{"creatorName":"オオイワ, ヒロアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Oiwa, Hiroaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"モリタ, マサヒロ","creatorNameLang":"ja"},{"creatorName":"モリタ, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Morita, Masahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"スズキ, チサト","creatorNameLang":"ja"},{"creatorName":"スズキ, チサト","creatorNameLang":"ja-Kana"},{"creatorName":"Suzuki, Chisato","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"スギヤマ, マコト","creatorNameLang":"ja"},{"creatorName":"スギヤマ, マコト","creatorNameLang":"ja-Kana"},{"creatorName":"Sugiyama, Makoto","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤマカワ, ノリオ","creatorNameLang":"ja"},{"creatorName":"ヤマカワ, ノリオ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamakawa, Norio","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タカダ, ヒトミ","creatorNameLang":"ja"},{"creatorName":"タカダ, ヒトミ","creatorNameLang":"ja-Kana"},{"creatorName":"Takada, Hitomi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マツムラ, シゲノブ","creatorNameLang":"ja"},{"creatorName":"マツムラ, シゲノブ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsumura, Shigenobu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イノウエ, カズオ","creatorNameLang":"ja"},{"creatorName":"イノウエ, カズオ","creatorNameLang":"ja-Kana"},{"creatorName":"Inoue, Kazuo","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"親泊, 政一","creatorNameLang":"ja"},{"creatorName":"オヤドマリ, セイイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Oyadomari, Seiichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"親泊","familyNameLang":"ja"},{"familyName":"オヤドマリ","familyNameLang":"ja-Kana"},{"familyName":"Oyadomari","familyNameLang":"en"}],"givenNames":[{"givenName":"政一","givenNameLang":"ja"},{"givenName":"セイイチ","givenNameLang":"ja-Kana"},{"givenName":"Seiichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"305","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"172432/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/172432/profile-ja.html"},{"nameIdentifier":"90502534","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=90502534"}]},{"creatorNames":[{"creatorName":"スギノ, ヒロム","creatorNameLang":"ja"},{"creatorName":"スギノ, ヒロム","creatorNameLang":"ja-Kana"},{"creatorName":"Sugino, Hiromu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"クリサキ, アキラ","creatorNameLang":"ja"},{"creatorName":"クリサキ, アキラ","creatorNameLang":"ja-Kana"},{"creatorName":"Kurisaki, Akira","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-10-30"}],"displaytype":"detail","filename":"celrep_25_5_1193.pdf","filesize":[{"value":"3.56 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2007980/files/celrep_25_5_1193.pdf"},"version_id":"409af3d4-fce5-4efe-a969-25360c5e9104"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Activin E Controls Energy Homeostasis in Both Brown and White Adipose Tissues as a Hepatokine","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Activin E Controls Energy Homeostasis in Both Brown and White Adipose Tissues as a Hepatokine","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-10-30"},"publish_date":"2020-10-30","publish_status":"0","recid":"2007980","relation_version_is_last":true,"title":["Activin E Controls Energy Homeostasis in Both Brown and White Adipose Tissues as a Hepatokine"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-27T06:44:59.437457+00:00"}