{"created":"2024-10-30T10:08:41.621748+00:00","id":2007984,"links":{},"metadata":{"_buckets":{"deposit":"6bf69787-5e32-4f0f-8857-de7dfed7414e"},"_deposit":{"created_by":7,"id":"2007984","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2007984"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02007984","sets":["1713853213384:1713853295607"]},"author_link":["209","322","1563","1531","969","1542"],"control_number":"2007984","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-16","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"1321","bibliographicPageStart":"1313","bibliographicVolumeNumber":"19","bibliographic_titles":[{"bibliographic_title":"Cell Reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Thymidine phosphorylase (TP), a rate-limiting enzyme in thymidine catabolism, plays a pivotal role in tumor progression; however, the mechanisms underlying this role are not fully understood. Here, we found that TP-mediated thymidine catabolism could supply the carbon source in the glycolytic pathway and thus contribute to cell survival under conditions of nutrient deprivation. In TP-expressing cells, thymidine was converted to metabolites, including glucose 6-phosphate, lactate, 5-phospho-α-D-ribose 1-diphosphate, and serine, via the glycolytic pathway both in vitro and in vivo. These thymidine-derived metabolites were required for the survival of cells under low-glucose conditions. Furthermore, activation of thymidine catabolism was observed in human gastric cancer. These findings demonstrate that thymidine can serve as a glycolytic pathway substrate in human cancer cells.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the CC BY-NC-ND license 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