{"created":"2024-11-22T06:25:45.636041+00:00","id":2008030,"links":{},"metadata":{"_buckets":{"deposit":"ad79410d-d6cd-4590-92a2-76be4ba9fd8a"},"_deposit":{"created_by":7,"id":"2008030","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2008030"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02008030","sets":["1713853213384:1713853295607"]},"author_link":["232","188"],"control_number":"2008030","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-09-14","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"256","bibliographicPageStart":"247","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"EBioMedicine","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"CXCL14 is a primordial chemokine that plays multiple roles in tumor suppression, autoimmune arthritis, and obesity-associated insulin resistance. However, the underlying molecular mechanisms are unclear. Here, we show that CXCL14 transports various types of CpG oligodeoxynucleotide (ODN) into the endosomes and lysosomes of bone marrow-derived dendritic cells (DCs), thereby activating Toll-like receptor 9 (TLR9). A combination of CpG ODN (ODN2395) plus CXCL14 induced robust production of IL-12 p40 by wild-type, but not Tlr9-knockout, DCs. Consistent with this, ODN2395-mediated activation of DCs was significantly attenuated in Cxcl14-knockout mice. CXCL14 bound CpG ODN with high affinity at pH 7.5, but not at pH 6.0, thereby enabling efficient delivery of CpG ODN to TLR9 in the endosome/lysosome. Furthermore, the CXCL14-CpG ODN complex specifically bound to high affinity CXCL14 receptors on DCs. Thus, CXCL14 serves as a specific carrier of CpG DNA to sensitize TLR9-mediated immunosurveillance.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"23523964","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.ebiom.2017.09.012"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.ebiom.2017.09.012","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"333468"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"タネガシマ, コウスケ","creatorNameLang":"ja"},{"creatorName":"タネガシマ, コウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanegashima, Kosuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タカハシ, レナ","creatorNameLang":"ja"},{"creatorName":"タカハシ, レナ","creatorNameLang":"ja-Kana"},{"creatorName":"Takahashi, Rena","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヌリヤ, ヒデコ","creatorNameLang":"ja"},{"creatorName":"ヌリヤ, ヒデコ","creatorNameLang":"ja-Kana"},{"creatorName":"Nuriya, Hideko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イワセ, リナ","creatorNameLang":"ja"},{"creatorName":"イワセ, リナ","creatorNameLang":"ja-Kana"},{"creatorName":"Iwase, Rina","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ナルセ, ナオト","creatorNameLang":"ja"},{"creatorName":"ナルセ, ナオト","creatorNameLang":"ja-Kana"},{"creatorName":"Naruse, Naoto","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ツジ, コウヘイ","creatorNameLang":"ja"},{"creatorName":"ツジ, コウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsuji, Kohei","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"重永, 章","creatorNameLang":"ja"},{"creatorName":"シゲナガ, アキラ","creatorNameLang":"ja-Kana"},{"creatorName":"Shigenaga, Akira","creatorNameLang":"en"}],"familyNames":[{"familyName":"重永","familyNameLang":"ja"},{"familyName":"シゲナガ","familyNameLang":"ja-Kana"},{"familyName":"Shigenaga","familyNameLang":"en"}],"givenNames":[{"givenName":"章","givenNameLang":"ja"},{"givenName":"アキラ","givenNameLang":"ja-Kana"},{"givenName":"Akira","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"232","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10423394","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10423394"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"大髙, 章","creatorNameLang":"ja"},{"creatorName":"オオタカ, 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Takahiko","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-12-17"}],"displaytype":"detail","filename":"ebiom_24_247.pdf","filesize":[{"value":"1.49 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2008030/files/ebiom_24_247.pdf"},"version_id":"dc4026a1-ba3e-4ee3-b327-c6533e71d2aa"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CXCL14","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"TLR9","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CpG DNA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dendritic cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"CXCL14 Acts as a Specific Carrier of CpG DNA into Dendritic Cells and Activates Toll-like Receptor 9-mediated Adaptive Immunity","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"CXCL14 Acts as a Specific Carrier of CpG DNA into Dendritic Cells and Activates Toll-like Receptor 9-mediated Adaptive Immunity","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-12-17"},"publish_date":"2020-12-17","publish_status":"0","recid":"2008030","relation_version_is_last":true,"title":["CXCL14 Acts as a Specific Carrier of CpG DNA into Dendritic Cells and Activates Toll-like Receptor 9-mediated Adaptive Immunity"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T05:21:04.388233+00:00"}