{"created":"2024-11-22T06:26:11.965595+00:00","id":2008033,"links":{},"metadata":{"_buckets":{"deposit":"9465f11a-4286-46b4-9016-53f89533c3de"},"_deposit":{"created_by":7,"id":"2008033","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2008033"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02008033","sets":["1713853213384:1713853295607"]},"author_link":["301"],"control_number":"2008033","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-10-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageStart":"e47728","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"EMBO Reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Ubiquitylation of outer mitochondrial membrane (OMM) proteins is closely related to the onset of familial Parkinson's disease. Typically, a reduction in the mitochondrial membrane potential results in Parkin‐mediated ubiquitylation of OMM proteins, which are then targeted for proteasomal and mitophagic degradation. The role of ubiquitylation of OMM proteins with non‐degradative fates, however, remains poorly understood. In this study, we find that the mitochondrial E3 ubiquitin ligase MITOL/March5 translocates from depolarized mitochondria to peroxisomes following mitophagy stimulation. This unusual redistribution is mediated by peroxins (peroxisomal biogenesis factors) Pex3/16 and requires the E3 ligase activity of Parkin, which ubiquitylates K268 in the MITOL C‐terminus, essential for p97/VCP‐dependent mitochondrial extraction of MITOL. These findings imply that ubiquitylation directs peroxisomal translocation of MITOL upon mitophagy stimulation and reveal a novel role for ubiquitin as a sorting signal that allows certain specialized proteins to escape from damaged mitochondria.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"EMBO Press","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the terms of the Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14693178","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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Koji","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"小迫, 英尊","creatorNameLang":"ja"},{"creatorName":"コサコ, ヒデタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Kosako, Hidetaka","creatorNameLang":"en"}],"familyNames":[{"familyName":"小迫","familyNameLang":"ja"},{"familyName":"コサコ","familyNameLang":"ja-Kana"},{"familyName":"Kosako","familyNameLang":"en"}],"givenNames":[{"givenName":"英尊","givenNameLang":"ja"},{"givenName":"ヒデタカ","givenNameLang":"ja-Kana"},{"givenName":"Hidetaka","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"301","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"172252/profile-ja.html","nameIdentifierScheme":"徳島大学 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ノリユキ","creatorNameLang":"ja"},{"creatorName":"マツダ, ノリユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsuda, Noriyuki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"embr_20_12_e47728.pdf","filesize":[{"value":"8.78 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2008033/files/embr_20_12_e47728.pdf"},"version_id":"141de1d3-5c01-4e51-96ec-4de31ae6a1c9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"March5","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"peroxin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"PINK1- and Parkin-mediated mitophagy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ubiquitin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"VCP","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Parkin‐mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Parkin‐mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-12-18"},"publish_date":"2020-12-18","publish_status":"0","recid":"2008033","relation_version_is_last":true,"title":["Parkin‐mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T06:55:15.319077+00:00"}