{"created":"2024-11-22T06:27:08.454630+00:00","id":2008043,"links":{},"metadata":{"_buckets":{"deposit":"0aa23ce6-38dd-4494-91c3-eae8dce771ca"},"_deposit":{"created_by":7,"id":"2008043","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2008043"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02008043","sets":["1713853213384:1713853295607"]},"author_link":["756","908"],"control_number":"2008043","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"AMINO ACID PROFILES IN MICE WITH NASH","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"428","bibliographicPageStart":"417","bibliographicVolumeNumber":"68","bibliographic_titles":[{"bibliographic_title":"Experimental Animals","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The changes in free amino acid (AA) levels in blood during the progression from non-alcoholic steatohepatitis (NASH) to hepatocellular carcinoma (HCC) are unclear. We investigated serum AA levels, along with biochemical and histological events, in a mouse model of NASH. We induced NASH in male C57BL/6J mice with a streptozotocin injection and high-fat diet after 4 weeks of age (STAM group). We chronologically (6, 8, 10, 12, and 16 weeks, n=4–12 mice/group) evaluated the progression from steatohepatitis to HCC by biochemical and histological analyses. The serum AA levels were determined using an AA analyzer. Serum aspartate aminotransferase and alanine aminotransferase levels were higher in the STAM group than in the normal group (non-NASH-induced mice). Histological analysis revealed that STAM mice had fatty liver, NASH, and fibrosis at 6, 8, and 10 weeks, respectively. Moreover, the mice exhibited fibrosis and HCC at 16 weeks. The serum branched-chain AA levels were higher in the STAM group than in the normal group, especially at 8 and 10 weeks. The Fischer ratio decreased at 16 weeks in the STAM group, with increasing aromatic AA levels. These results suggested that this model sequentially depicts the development of fatty liver, NASH, cirrhosis, HCC, and AA metabolism disorders within a short experimental period. Additionally, serum amyloid A was suggested to be a useful inflammation biomarker associated with NASH. We believe that the STAM model will be useful for studying AA metabolism and/or pharmacological effects in NASH.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Association for Laboratory Animal Science","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License <http://creativecommons.org/licenses/by-nc-nd/4.0/>.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13411357","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"18817122","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11032321","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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Mayuko","creatorNameLang":"en"}],"familyNames":[{"familyName":"(市村)清水","familyNameLang":"ja"},{"familyName":"(イチムラ)シミズ","familyNameLang":"ja-Kana"},{"familyName":"Ichimura-Shimizu","familyNameLang":"en"}],"givenNames":[{"givenName":"真祐子","givenNameLang":"ja"},{"givenName":"マユコ","givenNameLang":"ja-Kana"},{"givenName":"Mayuko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"908","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"336324/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/336324/profile-ja.html"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"常山, 幸一","creatorNameLang":"ja"},{"creatorName":"ツネヤマ, コウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsuneyama, Koichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"常山","familyNameLang":"ja"},{"familyName":"ツネヤマ","familyNameLang":"ja-Kana"},{"familyName":"Tsuneyama","familyNameLang":"en"}],"givenNames":[{"givenName":"幸一","givenNameLang":"ja"},{"givenName":"コウイチ","givenNameLang":"ja-Kana"},{"givenName":"Koichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"756","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"289954/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/289954/profile-ja.html"},{"nameIdentifier":"10293341","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10293341"}]},{"creatorNames":[{"creatorName":"マサキ, タカユキ","creatorNameLang":"ja"},{"creatorName":"マサキ, タカユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Masaki, Takayuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"セイケ, マサタカ","creatorNameLang":"ja"},{"creatorName":"セイケ, マサタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Seike, Masataka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ナカムラ, ツヨシ","creatorNameLang":"ja"},{"creatorName":"ナカムラ, ツヨシ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakamura, Tsuyoshi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-12-24"}],"displaytype":"detail","filename":"expanim_68_4_417.pdf","filesize":[{"value":"4.83 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2008043/files/expanim_68_4_417.pdf"},"version_id":"e6366bdb-de90-4a63-b862-d104a51f6a45"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"amino acid metabolism disorder","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"diabetes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hyperlipidemia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"non-alcoholic fatty liver disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"non-alcoholic steatohepatitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Analysis of amino acid profiles of blood over time and biomarkers associated with non-alcoholic steatohepatitis in STAM mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Analysis of amino acid profiles of blood over time and biomarkers associated with non-alcoholic steatohepatitis in STAM mice","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-12-24"},"publish_date":"2020-12-24","publish_status":"0","recid":"2008043","relation_version_is_last":true,"title":["Analysis of amino acid profiles of blood over time and biomarkers associated with non-alcoholic steatohepatitis in STAM mice"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-13T06:41:51.646085+00:00"}