{"created":"2024-11-22T06:30:44.043442+00:00","id":2008085,"links":{},"metadata":{"_buckets":{"deposit":"89e8e833-92fc-4a9c-bd79-fc702982807b"},"_deposit":{"created_by":7,"id":"2008085","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2008085"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02008085","sets":["1713853213384:1713853295607"]},"author_link":["414"],"control_number":"2008085","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Myeloid S100 proteins reduce lung inflammation","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-01-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"472","bibliographicPageStart":"461","bibliographicVolumeNumber":"95","bibliographic_titles":[{"bibliographic_title":"Immunology & Cell Biology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"S100A8 and S100A9 are myeloid cell‐derived proteins that are elevated in several types of inflammatory lung disorders. Pro‐ and anti‐inflammatory properties are reported and these proteins are proposed to activate TLR4. S100A8 and S100A9 can function separately, likely through distinct receptors but a systematic comparison of their effects in vivo are limited. Here we assess inflammation in murine lung following S100A9 and S100A8/A9 inhalation. Unlike S100A8, S100A9 promoted mild neutrophil and lymphocyte influx, possibly mediated in part, by increased mast cell degranulation and selective upregulation of some chemokine genes, particularly CXCL‐10. S100 proteins did not significantly induce proinflammatory mediators including TNF‐α, interleukin‐1β (IL‐1β), IL‐6 or serum amyloid A3 (SAA3). In contrast to S100A8, neither preparation induced S100A8 or IL‐10 mRNA/protein in airway epithelial cells, or in tracheal epithelial cells in vitro. Like S100A8, S100A9 and S100A8/A9 reduced neutrophil influx in acute lung injury provoked by lipopolysaccharide (LPS) challenge but were somewhat less inhibitory, possibly because of differential effects on expression of some chemokines, IL‐1β, SAA3 and IL‐10. Novel common pathways including increased induction of an NAD+‐dependent protein deacetylase sirtuin‐1 that may reduce NF‐κB signalling, and increased STAT3 activation may reduce LPS activation. Results suggest a role for these proteins in normal homeostasis and protective mechanisms in the lung.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Australian and New Zealand Society for Immunology","subitem_publisher_language":"en"},{"subitem_publisher":"Wiley","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission fromthe license holder to reproduce thematerial. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14401711","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10678685","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1038/icb.2017.2"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/icb.2017.2","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"322120"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"廣島, 佑香","creatorNameLang":"ja"},{"creatorName":"ヒロシマ, ユカ","creatorNameLang":"ja-Kana"},{"creatorName":"Hiroshima, Yuka","creatorNameLang":"en"}],"familyNames":[{"familyName":"廣島","familyNameLang":"ja"},{"familyName":"ヒロシマ","familyNameLang":"ja-Kana"},{"familyName":"Hiroshima","familyNameLang":"en"}],"givenNames":[{"givenName":"佑香","givenNameLang":"ja"},{"givenName":"ユカ","givenNameLang":"ja-Kana"},{"givenName":"Yuka","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"414","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"204938/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/204938/profile-ja.html"},{"nameIdentifier":"60545143","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60545143"}]},{"creatorNames":[{"creatorName":"Hsu, Kenneth","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tedla, Nicodemus","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Wong, Sze Wing","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Chow, Sharron","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カワグチ, ナオミ","creatorNameLang":"ja"},{"creatorName":"カワグチ, ナオミ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawaguchi, Naomi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Geczy, Carolyn L","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-02-08"}],"displaytype":"detail","filename":"icb_95_5_461.pdf","filesize":[{"value":"2.99 MB"}],"format":"application/pdf","licensetype":"license_4","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2008085/files/icb_95_5_461.pdf"},"version_id":"d9375dc9-14f9-4de7-930c-3145687b9bca"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"S100A8/A9 and S100A9 reduce acute lung injury","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"S100A8/A9 and S100A9 reduce acute lung injury","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-02-08"},"publish_date":"2021-02-08","publish_status":"0","recid":"2008085","relation_version_is_last":true,"title":["S100A8/A9 and S100A9 reduce acute lung injury"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-27T06:04:20.870290+00:00"}